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MPP4 gene is highly expressed in retina, but no mutations were identified in a panel of 300 unrelated patients with retinitis pigmentosa.
Results describe the temporal and spatial expression patterns of mouse membrane palmitoylated protein 4 (Mpp4) gene.
Association of Veli3 with MPP4 suggests that the MAGUKs recruit Veli3 and its binding partners to different cellular regions of the retina where they may participate in the organization of specialized intercellular junctions.
These findings suggest that Mpp4 coordinates Psd95 (show DLG4 Proteins)/Veli3 assembly and maintenance at synaptic membranes. Mpp4 is a critical recruitment factor to organize scaffolds at the photoreceptor synapse.
Results show that Mpp4 organizes a presynaptic protein complex and has a role in modulating Ca(2 (show CA2 Proteins)+) homeostasis and synaptic transmission in rod photoreceptors.
Data suggest that both scaffold proteins PSD95beta and MPP4 are essential for the modulation of PMCA levels at the presynaptic plasma membrane and thereby influence the photoreceptor synaptic calcium handling.
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) protein family, with an N-terminal PDZ domain, a central src homology 3 region (SH3), and a C-terminal guanylate kinase-like (GUK) domain. The protein is localized to the outer limiting membrane in the retina, and is thought to function in photoreceptor polarity and the organization of specialized intercellular junctions. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
MAGUK p55 subfamily member 4
, amyotrophic lateral sclerosis 2 chromosomal region candidate gene 5 protein
, discs large homolog 6
, discs, large homolog 6
, membrane palmitoylated protein 4