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anti-Human STX8 Antibodies:
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Human Polyclonal STX8 Primary Antibody for ICC, IP - ABIN1742226
Offenhäuser, Lei, Roy, Collins, Stow, Murray: Syntaxin 11 binds Vti1b and regulates late endosome to lysosome fusion in macrophages. in Traffic (Copenhagen, Denmark) 2011
Show all 7 Pubmed References
Dog (Canine) Monoclonal STX8 Primary Antibody for IF, WB - ABIN968490
Steegmaier, Yang, Yoo, Huang, Shen, Yu, Luo, Scheller: Three novel proteins of the syntaxin/SNAP-25 family. in The Journal of biological chemistry 1999
Show all 2 Pubmed References
Dog (Canine) Monoclonal STX8 Primary Antibody for IF, WB - ABIN968489
Thoreau, Bergès, Callebaut, Guillier-Gencik, Gressin, Bernheim, Karst, Mornon, Kitzis, Chomel: Molecular cloning, expression analysis, and chromosomal localization of human syntaxin 8 (STX8). in Biochemical and biophysical research communications 1999
Show all 2 Pubmed References
Stx8 is required for proper and timely sorting and trafficking of cytotoxic molecules to functional lytic granules through the endosomal pathway in human cytotoxic t-lymphocytes.
Increased STX8 expression in visceral adipose tissue appears to be associated with the presence of type 2 diabetes in obese patients through a mechanism that may involve GLUT4 (show SLC2A4 Antibodies).
Syntaxin 8 has a role in regulating platelet dense granule secretion, aggregation, and thrombus stability
Syntaxin-8 regulates the endocytosis of TASK-1 (show KCNK3 Antibodies).
These results suggest that STX8 mediates the recycling of CLDN16 (show CLDN16 Antibodies) and constitutes an important component of the CLDN16 (show CLDN16 Antibodies) trafficking machinery in the kidney.
syntaxin 8 contributes to the regulation of CFTR (show CFTR Antibodies) trafficking and chloride channel (show CLCA1 Antibodies) activity by the SNARE (show NAPA Antibodies) machinery
Results report that syntaxin 7 (show STX7 Antibodies), syntaxin 8, vti1b (show VTI1B Antibodies) and VAMP8 (show VAMP8 Antibodies) physically and functionally interact with CFTR (show CFTR Antibodies).
Palmitoylation does not affect the rate of protein turnover of syntaxins 7 and 8 nor does it influence the steady-state localization of syntaxin 8 in late endosomes.
Syntaxin 8 and HECTd3 (show HECTD3 Antibodies) have similar subcellular localization.
The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants.
, syntaxin 8
, t-SNARE family protein
, CIP-1-associated regulator of cyclin B
, syntaxin-like protein 3I35