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Plexin C1 deficiency permits synaptotagmin 7-mediated macrophage mig (show PLXNC1 Proteins)ration and enhances mammalian lung fibrosis
RNA knockdown of Syt-7 in human islets reduced first- and second-phase glucose-stimulated insulin (show INS Proteins) secretion attributed to the reduction of exocytosis of predocked and newcomer insulin (show INS Proteins) secretory granules
Data indicate that small protein sequence changes in the Ca(2 (show CA2 Proteins)+)-binding loops of the C2 domains may give rise to the difference in binding kinetics between Syt-1 (show SYT1 Proteins) and Syt-7 isoforms.
the results suggest that the two C2 domains of Syt7 bind independently to planar membranes, in contrast to reported interdomain cooperativity in Syt1 (show SYT1 Proteins)
The membrane dissociation of SYT7 C2A domain but not SYT1 C2A domain is slowed by Na(2)SO(4) and trehalose, solutes that enhance the hydrophobic effect.
identified the conserved alternative splicing events in the spacer domain of Syt VII; also shown that Syt (show SS18 Proteins) VIIa-GFP is mainly localized in the perinuclear region and tips of neurites (dense-core vesicles), and not in the plasma membrane
data demonstrate the previously unrecognized observation that PLXNC1 (show PLXNC1 Proteins) deficiency permits Syt7-mediated macrophage migration and enhances mammalian lung fibrosis
At the calyx synapse that syt7-dependent asynchronous release indeed does not produce a prolonged synaptic signal after a stimulus train and does not contribute to short-term plasticity, but induces a steady-state, asynchronous postsynaptic current during stimulus trains. This steady-state postsynaptic current sustains reliable generation of postsynaptic spikes that are precisely time locked to presynaptic spikes.
results suggest that postsynaptic Syt1 (show SYT1 Proteins) and Syt7 act as redundant Ca(2 (show CA2 Proteins)+)-sensors for Ca(2 (show CA2 Proteins)+)-dependent exocytosis of AMPA (show GRIA3 Proteins) receptors during long-term potentiation, and thereby delineate a simple mechanism for the recruitment of AMPA (show GRIA3 Proteins) receptors that mediates LTP (show SCP2 Proteins)
Data (including data from studies in knockout mice) suggest that loss of both Syt1 (show SYT1 Proteins)/Syt7 decreases capacity of readily-releasable pool (RRP (show RRBP1 Proteins)) of Ca2 (show CA2 Proteins)+ in synaptic vesicles without altering rate of priming into RRP (show RRBP1 Proteins); Syt1 (show SYT1 Proteins)/Syt7 functions appear redundant.
synaptotagmin 7 (Syt7) is a calcium sensor that is required for facilitation at several central synapses
Use of neurons from double-knock-out (SNAP-25 (show SNAP25 Proteins), synaptotagmin-7) mice in combination with viral transduction showed that SNAP-23 (show SNAP23 Proteins)-driven release is triggered by endogenous synaptotagmin-7
Complex of syt 7 and calmodulin serves as a key regulator of synaptic vesicle replenishment in presynaptic nerve terminals.
synaptotagmin-7 is directly activated by GLP-1 (show GCG Proteins) signaling and may serve as a drug target for boosting insulin (show INS Proteins) secretion.
knock-out of synaptotagmin-7 selectively impaired delayed asynchronous neurotransmitter release but not synchronous release. In contrast, the readily releasable vesicles after depletion recover normally in knock-out mice.
Ca(2 (show CA2 Proteins)+)-triggered release at a synapse is due to synaptotagmins, with synaptotagmin-7 mediating a slower form of Ca(2 (show CA2 Proteins)+)-triggered release that is normally occluded by faster synaptotagmin-1 (show SYT1 Proteins)-induced release but becomes manifest upon synaptotagmin-1 (show SYT1 Proteins) deletion
This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. A similar protein in rodents mediates hormone secretion and lysosome exocytosis. In humans, expression of this gene has been associated with prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, synaptotagmin VII
, synaptotagmin 7
, prostate cancer-associated protein 7