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|Application / Reactivity||Mouse (Murine)||Human|
|ELISA||18 Antibodies||71 Antibodies|
|Enzyme Immunoassay (EIA)||2 Antibodies||2 Antibodies|
|Flow Cytometry (FACS)||7 Antibodies||54 Antibodies|
|Immunocytochemistry (ICC)||7 Antibodies||16 Antibodies|
|Immunofluorescence (IF)||11 Antibodies||37 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||12 Antibodies|
|Immunohistochemistry (IHC)||19 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||10 Antibodies|
|Western Blotting (WB)||38 Antibodies|
|Immunochromatography (IC)||4 Antibodies|
|Antigen||B-Cell CLL/lymphoma 10 (BCL10) Antibodies|
|Epitope||AA 27-55, N-Term Alternatives|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This BCL10 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|5 references available|
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Product Details anti-BCL10 AntibodyTarget Details BCL10 Application Details Handling References for anti-BCL10 Antibody (ABIN950621) Images
|Specificity||This antibody reats to Bcl-10.|
|Cross-Reactivity (Details)||Species reactivity (tested):Human and Mouse.|
|Purification||Affinity chromatography on Protein A|
|Immunogen||KLH conjugated synthetic peptide between 27-55 amino acids from the N-terminal region of human BCL10|
Target Details BCL10Product Details anti-BCL10 Antibody Application Details Handling References for anti-BCL10 Antibody (ABIN950621) Images back to top
|Alternative Name||Bcl-10 (BCL10 Antibody Abstract)|
|Background||This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.Synonyms: B-cell CLL/lymphoma 10, BCL10, CARD-containing molecule enhancing NF-kappa-B, CARD-like apoptotic protein, CED-3/ICH-1 prodomain homologous E10-like regulator, CIPER, CLAP, Cellular homolog of vCARMEN, Cellular-E10, Mammalian CARD-containing adapter molecule E10, c-E10, cCARMEN, hCLAP, mE10|
|Pathways||TCR Signaling, Fc-epsilon Receptor Signaling Pathway|
Application DetailsProduct Details anti-BCL10 Antibody Target Details BCL10 Handling References for anti-BCL10 Antibody (ABIN950621) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-BCL10 Antibody Target Details BCL10 Application Details References for anti-BCL10 Antibody (ABIN950621) Images back to top
|Buffer||PBS containing 0.09 % (W/V) sodium azide as preservative|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
References for anti-BCL10 Antibody (ABIN950621)Product Details anti-BCL10 Antibody Target Details BCL10 Application Details Handling Images back to top
Rehman, Wang: "CXCL12/SDF-1 alpha activates NF-kappaB and promotes oral cancer invasion through the Carma3/Bcl10/Malt1 complex." in: International journal of oral science, Vol. 1, Issue 3, pp. 105-18, 2010 (PubMed).
Bhattacharyya, Borthakur, Dudeja et al.: "Lipopolysaccharide-induced activation of NF-κB non-canonical pathway requires BCL10 serine 138 and NIK phosphorylations." in: Experimental cell research, Vol. 316, Issue 19, pp. 3317-27, 2010 (PubMed).
Edin, Oruganti, Grundström et al.: "Interaction of calmodulin with Bcl10 modulates NF-kappaB activation." in: Molecular immunology, Vol. 47, Issue 11-12, pp. 2057-64, 2010 (PubMed).
Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).
Bhattacharyya, Borthakur, Tyagi et al.: "B-cell CLL/lymphoma 10 (BCL10) is required for NF-kappaB production by both canonical and noncanonical pathways and for NF-kappaB-inducing kinase (NIK) phosphorylation." in: The Journal of biological chemistry, Vol. 285, Issue 1, pp. 522-30, 2009 (PubMed).
ImagesProduct Details anti-BCL10 Antibody Target Details BCL10 Application Details Handling References for anti-BCL10 Antibody (ABIN950621) back to top