Browse our HLA-DPB1 Proteins (HLA-DPB1)

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Major Histocompatibility Complex, Class II, DP beta 1 Proteins (HLA-DPB1)
On are 8 Major Histocompatibility Complex, Class II, DP beta 1 (HLA-DPB1) Proteins from 3 different suppliers available. Additionally we are shipping HLA-DPB1 Antibodies (122) and many more products for this protein. A total of 134 HLA-DPB1 products are currently listed.
list all proteins Gene Name GeneID UniProt
HLA-DPB1 3115 P04440

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Human Major Histocompatibility Complex, Class II, DP beta 1 (HLA-DPB1) interaction partners

  1. Two new signals were observed at genome-wide significance (P < 5 x 10-8), namely, rs7216064 (17q24.3, BPTF), for overall lung adenocarcinoma risk, and rs3817963 (6p21.3, BTNL2 (show BTNL2 Proteins)) which is specific to cases with EGFR (show EGFR Proteins) mutations. In further sub-analyses by EGFR (show EGFR Proteins) status, rs9387478 (ROS1 (show ROS1 Proteins)/DCBLD1) and rs2179920 (HLA-DPB1) showed stronger estimated associations in EGFR (show EGFR Proteins)-positive compared to EGFR (show EGFR Proteins)-negative cases

  2. The HLA-B*42, HLA-C*17, HLA-DPA1*03, and HLA-DPB1*105 genotypes were associated with allergic asthma and the HLA-B*48 genotype with the nonallergic phenotype.

  3. we show strong immunogenicity of HLA-DPB1 mismatch alleles in CD45RA-selected CD4 (show CD4 Proteins) T cells of stem-cell donors and introduce a novel strategy to reliably generate HLA-DPB1-specific CD4 (show CD4 Proteins) CTL that might be powerful cellular therapeutics in relapsed or refractory AML (show RUNX1 Proteins) after HSCT.

  4. There was no increased risk of rheumatoid arthritis in mothers of children with phenylalanine at position 9 of DPB1.

  5. rs141530233 and rs1042169 at the HLA-DPB1 locus are associated with ANCA-associated vasculitis risk.

  6. Seven nonconservative AA substitutions in peptide-binding positions had a significantly stronger impact on DeltaFD compared with 5 others (P = .0025), demonstrating qualitative differences in the relative impact of AA polymorphism in HLA-DPB1.

  7. Study showed that HLA-DQ (rs7453920) was associated with prognosis of liver transplant recipients. The A allele of rs7453920 served as a protective factor in liver function recovery. HLA-DP (rs3077 and rs9277535) did not show any correlation with the hepatitis B virus infection and prognosis.

  8. this study shows that HLA-DP gene polymorphisms are associated with ankylosing spondylitis in Southwest China

  9. DRB1 (show RBM45 Proteins)*13:02 (P = 0.0011, Pc = 0.0319, odds ratio [OR] 0.46, 95% confidence interval [CI] 0.29-0.73), DRB1 (show RBM45 Proteins)*14:06 (P = 6.60X10-5, Pc = 0.0020, OR 0.05, 95%CI 0.01-0.41), DQB1*03:01 (P = 0.0009, Pc = 0.0150, OR 0.56, 95%CI 0.40-0.79), and DPB1*02:01 (P = 5.16X10-6, Pc = 8.77X10-5, OR 0.52, 95%CI 0.39-0.69) were protectively associated with Systemic Sclerosis in Japanese.

  10. The HLA-DPB1*04:01:01G allele was significantly more frequent among women diagnosed with severe preeclampsia/eclampsia compared with controls.

HLA-DPB1 Protein Profile

Protein Summary

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

Alternative names and synonyms associated with HLA-DPB1

  • major histocompatibility complex, class II, DP beta 1 (PATR-DPB1)
  • Major histocompatibility complex class II beta chain BLB2, (similar to HLA class II, D beta chain) (BLB2)
  • major histocompatibility complex, class II, DP beta 1 (HLA-DPB1)
  • B-LB protein
  • B-LB2 protein
  • B-LB21 protein
  • BLB1 protein
  • DPB1 protein
  • GSP-BLB1 protein
  • HLA-DP protein
  • HLA-DP1B protein
  • HLA-DPB protein
  • PATR-DPB1 protein

Protein level used designations for HLA-DPB1

major histocompatibility complex, class II, DP beta 1 , B-L beta minor , BLB major , Bl-Beta II protein , MHC class II B-L beta chain , MHC class II antigen beta chain , MHC class II beta 1 domain , MHC class II beta chain 1 , MHC class II beta chain 2 , major histocompatibility complex class II B , HLA DP14-beta chain , HLA class II histocompatibility antigen, DP beta 1 chain , HLA class II histocompatibility antigen, DP(W4) beta chain , HLA-DP histocompatibility type, beta-1 subunit , MHC HLA DPB1 , MHC class II HLA-DP-beta-1 , MHC class II HLA-DRB1 , MHC class II antigen DP beta 1 chain , MHC class II antigen DPB1 , MHC class II antigen DPbeta1 , beta1 domain MHC class II HLA DPB , class II HLA beta chain , major histocompatibility complex class II antigen beta chain

462599 Pan troglodytes
693256 Gallus gallus
3115 Homo sapiens
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