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anti-Mouse (Murine) IL17A antibody for Biochemical Assay

Recommended IL17A Antibody (supplied by: Log in to see )

Antigen
Interleukin 17A (IL17A) Antibodies
  • ChIL-17
  • Ctla-8
  • CTLA-8
  • CTLA8
  • Ctla8
  • IL-17
  • IL-17A
  • IL-17F
  • IL17
  • Il17
  • IL17A
Reactivity
Mouse (Murine)
431
193
72
10
5
5
1
Host
Rat
248
207
110
44
8
3
1
Clonality
Monoclonal
Conjugate
This IL17A antibody is un-conjugated
71
34
34
24
17
16
14
11
8
7
7
7
7
7
7
7
7
7
6
6
5
5
4
3
3
3
2
2
2
2
2
2
2
2
2
1
1
Application
Biochemical Assay (BCA)
345
312
193
59
43
42
24
22
19
15
11
10
9
9
9
8
7
6
5
4
3
3
2
2
2
2
2
1
1
1
1
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Catalog No. ABIN2665823
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Top referenced anti-IL17A antibody for Biochemical Assay

Similar anti-IL17A Antibodies

Application / Reactivity Mouse (Murine)
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Confocal Microscopy (CM) 2 Antibodies
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General

Antigen Interleukin 17A (IL17A) Antibodies
Reactivity Mouse (Murine)
(431), (193), (72), (10), (5), (5), (1)
Host Rat
(248), (207), (110), (44), (8), (3), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This IL17A antibody is un-conjugated
(71), (34), (34), (24), (17), (16), (14), (11), (8), (7), (7), (7), (7), (7), (7), (7), (7), (7), (6), (6), (5), (5), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application Biochemical Assay (BCA)
(345), (312), (193), (59), (43), (42), (24), (22), (19), (15), (11), (10), (9), (9), (9), (8), (7), (6), (5), (4), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Pubmed 6 references available
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Product Details anti-IL17A Antibody

Target Details IL17A Application Details Handling References for anti-IL17A Antibody (ABIN2665823) Images
Brand LEAF™
Purification The LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
Sterility 0.2 μm filtered
Endotoxin Level

Endotoxin level is <0.1 EU/μg of the protein (<0.01 ng/μg of the protein) as determined by the LAL test.

Clone TC11-8H4
Isotype IgG1 kappa

Target Details IL17A

Product Details anti-IL17A Antibody Application Details Handling References for anti-IL17A Antibody (ABIN2665823) Images back to top
Antigen
Alternative Name IL-17A (IL17A Antibody Abstract)
Background IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. Recent study has shown that IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course. The TC11-8H4 antibody antibody reacts with mouse interleukin-17 (IL-17).
Pathways TCR Signaling

Application Details

Product Details anti-IL17A Antibody Target Details IL17A Handling References for anti-IL17A Antibody (ABIN2665823) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-IL17A Antibody Target Details IL17A Application Details References for anti-IL17A Antibody (ABIN2665823) Images back to top
Concentration 1.0 mg/mL
Preservative Azide free
Handling Advice This LEAF™ solution contains no preservative, handle under aseptic conditions
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-IL17A Antibody (ABIN2665823)

Product Details anti-IL17A Antibody Target Details IL17A Application Details Handling Images back to top
Background publications

Herrada, Contreras, Marini, Amador, González, Cortés, Riedel, Carvajal, Figueroa, Michea, Fardella, Kalergis: "Aldosterone promotes autoimmune damage by enhancing Th17-mediated immunity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 1, pp. 191-202, 2009

Dong: "Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells." in: Nature reviews. Immunology, Vol. 6, Issue 4, pp. 329-33, 2006

Hofstetter, Ibrahim, Koczan, Kruse, Weishaupt, Toyka, Gold: "Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis." in: Cellular immunology, Vol. 237, Issue 2, pp. 123-30, 2006

Yao, Spriggs, Derry, Strockbine, Park, VandenBos, Zappone, Painter, Armitage: "Molecular characterization of the human interleukin (IL)-17 receptor." in: Cytokine, Vol. 9, Issue 11, pp. 794-800, 1998

Kennedy, Rossi, Zurawski, Vega, Kastelein, Wagner, Hannum, Zlotnik: "Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 16, Issue 8, pp. 611-7, 1997

Fossiez, Djossou, Chomarat, Flores-Romo, Ait-Yahia, Maat, Pin, Garrone, Garcia, Saeland, Blanchard, Gaillard, Das Mahapatra, Rouvier, Golstein, Banchereau, Lebecque: "T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines." in: The Journal of experimental medicine, Vol. 183, Issue 6, pp. 2593-603, 1996