|Application / Reactivity||Mouse (Murine)|
|Biochemical Assay (BCA)||1 Antibodies|
|Blocking Antibody (Inhibition)||3 Antibodies|
|Confocal Microscopy (CM)||2 Antibodies|
|ELISA (Capture)||1 Antibodies|
|ELISA (Detection)||1 Antibodies|
|ELISpot (Capture) (ELISPOT (Capture))||2 Antibodies|
|ELISpot (Detection) (ELISPOT (Detection))||1 Antibodies|
|Enzyme Immunoassay (EIA)||6 Antibodies|
|Flow Cytometry (FACS)||60 Antibodies|
|Immunocytochemistry (ICC)||4 Antibodies|
|Immunofluorescence (IF)||14 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies|
|Immunohistochemistry (IHC)||16 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||2 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||8 Antibodies|
|Immunoprecipitation (IP)||4 Antibodies|
|Antigen||Interleukin 17A (IL17A) Antibodies|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This IL17A antibody is un-conjugated Alternatives|
Biochemical Assay (BCA)
|6 references available|
|Supplier||Log in to see|
Product Details anti-IL17A AntibodyTarget Details IL17A Application Details Handling References for anti-IL17A Antibody (ABIN2665823) Images
|Purification||The LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.|
|Sterility||0.2 μm filtered|
Endotoxin level is <0.1 EU/μg of the protein (<0.01 ng/μg of the protein) as determined by the LAL test.
Target Details IL17AProduct Details anti-IL17A Antibody Application Details Handling References for anti-IL17A Antibody (ABIN2665823) Images back to top
|Alternative Name||IL-17A (IL17A Antibody Abstract)|
|Background||IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. Recent study has shown that IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course. The TC11-8H4 antibody antibody reacts with mouse interleukin-17 (IL-17).|
Application DetailsProduct Details anti-IL17A Antibody Target Details IL17A Handling References for anti-IL17A Antibody (ABIN2665823) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL17A Antibody Target Details IL17A Application Details References for anti-IL17A Antibody (ABIN2665823) Images back to top
|Handling Advice||This LEAF™ solution contains no preservative, handle under aseptic conditions|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-IL17A Antibody (ABIN2665823)Product Details anti-IL17A Antibody Target Details IL17A Application Details Handling Images back to top
Herrada, Contreras, Marini et al.: "Aldosterone promotes autoimmune damage by enhancing Th17-mediated immunity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 1, pp. 191-202, 2009 (PubMed).
Dong: "Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells." in: Nature reviews. Immunology, Vol. 6, Issue 4, pp. 329-33, 2006 (PubMed).
Hofstetter, Ibrahim, Koczan et al.: "Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis." in: Cellular immunology, Vol. 237, Issue 2, pp. 123-30, 2006 (PubMed).
Yao, Spriggs, Derry et al.: "Molecular characterization of the human interleukin (IL)-17 receptor." in: Cytokine, Vol. 9, Issue 11, pp. 794-800, 1998 (PubMed).
Kennedy, Rossi, Zurawski et al.: "Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 16, Issue 8, pp. 611-7, 1997 (PubMed).
Fossiez, Djossou, Chomarat et al.: "T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines." in: The Journal of experimental medicine, Vol. 183, Issue 6, pp. 2593-603, 1996 (PubMed).