|Antigen||Interleukin 17A (IL17A) Antibodies|
|Reactivity||Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This IL17A antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
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Product Details anti-IL17A AntibodyTarget Details IL17A Application Details Handling Images
|Characteristics||Concentration: 1.0 mg/mL (by UV absorbance at 280 nm)|
|Immunogen||Full-length recombinant Rat IL17-A protein . Genename: IL17A|
Target Details IL17AProduct Details anti-IL17A Antibody Application Details Handling Images back to top
|Alternative Name||Interleukin-17A (IL17A) (IL17A Antibody Abstract)|
|Background||Rat IL17-A (also known as Interleukin-17, Cytotoxic T-lymphocyteassociated antigen 8 and CTLA-8) is a proinflammatory cytokine member of a six-species family of proteins (IL-17A-17F). Rat IL-17A protein is a homodimer consisting of two 134 amino acids peptides. IL-17A is secreted mainly by activated CD4+ and CD8+ T lymphocytes and acts through its receptor, IL-17R, to induce the expression of many mediators of inflammation, most strikingly, those that are involved in the proliferation, maturation and chemotaxis of neutrophils. Elevated levels of IL-17A have been associated with several conditions, including rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer and multiple sclerosis. There is 58 % identity between the amino acid sequence of Human and Rat IL-17A.Synonyms: CTLA-8, CTLA8, Cytotoxic T-lymphocyte-associated antigen 8, IL-17, IL-17A, IL17|
|Research Area||Cancer, Cytokines, Immunology, Inflammation, Receptors, Virology|
Application DetailsProduct Details anti-IL17A Antibody Target Details IL17A Handling Images back to top
ELISA: 1/20000 - 1/100000. Western Blot: 1/500 - 1/2000. Neutralization: 1/400.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL17A Antibody Target Details IL17A Application Details Images back to top
|Reconstitution||Restore with 0.1 mL of deionized water (or equivalent).|
|Buffer||0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2 without preservatives and stabilizers. The Endotoxin content is estimated to be less than 10 pg/mL by the LAL method.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Prior to reconstitution store at 2-8 °C. Following reconstitution store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|