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anti-Human ACD Antibodies:
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Human Monoclonal ACD Primary Antibody for IF, IHC (p) - ABIN566298
Abreu, Aritonovska, Reichenbach, Cristofari, Culp, Terns, Lingner, Terns: TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo. in Molecular and cellular biology 2010
Show all 2 Pubmed References
a novel ACD mutation(p.G223V)is detected; ACD is a novel gene involved in childhood pre-B acute lymphoblastic leukemia and may play a functional role in enhancing leukemia cell survival
The data support a causal relationship between a TPP1 (show TPP1 Antibodies) mutation and bone marrow disorders in a family.
Clustering of novel mutations in the POT1 (show POT1 Antibodies) binding domain of ACD was statistically higher (P = .005) in melanoma probands compared with population control individuals (n = 6785).
Shelterin protein TPP 1 (show TPP1 Antibodies) interacts with hTERT and recruits hTERT onto the telomeres, suggesting that TPP 1 (show TPP1 Antibodies) might be involved in regulation of telomere shortening.
POT1 (show POT1 Antibodies)-TPP1 (show TPP1 Antibodies) binds telomeric DNA in a coordinated manner to facilitate assembly of the nucleoprotein complexes into a state that is more accessible to enzymatic activity.
Study shows that the OB-fold domain of the telomere-binding protein TPP1 (show TPP1 Antibodies) recruits telomerase to telomeres through an association with the telomerase reverse transcriptase TERT (show TERT Antibodies); data define a potential interface for telomerase-TPP1 (show TPP1 Antibodies) interaction required for telomere maintenance and implicate defective telomerase recruitment in telomerase-related disease.
a paper that firstly reported cloning of human TTP1 (PTOP) and its biological function at telomere. TPP1 (show TPP1 Antibodies) interacts with both POT1 (show POT1 Antibodies) and TIN2 (show TINF2 Antibodies), heterodimerizes with POT1 (show POT1 Antibodies) and regulates POT1 (show POT1 Antibodies) telomeric recruitment and telomere length.
The presence of dysfunctional telomeres in chronic lymphocytic leukemia did not correlate with telomere shortening or chromatin marks deregulation but with a down-regulation of 2 shelterin genes: ACD and TINF2 (show TINF2 Antibodies).
Results support a model in which POT1 (show POT1 Antibodies)-TPP1 (show TPP1 Antibodies) enhances telomerase processivity in a manner markedly different from the sliding clamps used by DNA polymerases.
TIN2 (show TINF2 Antibodies)-anchored TPP1 (show TPP1 Antibodies) plays a major role in the recruitment of telomerase to telomeres in human cells.
shelterin protein TIN2 (show TINF2 Antibodies) can protect chromosome ends as a TRF2 (show TERF2 Antibodies)-tethered TIN2 (show TINF2 Antibodies)/TPP1 (show TPP1 Antibodies)/POT1 (show POT1 Antibodies) complex that lacks a physical connection to TRF1 (show TERF1 Antibodies)
Mouse hematopoietic stem cells are acutely sensitive to inactivation of the shelterin gene Acd.
Tpp1 (show TPP1 Antibodies) is required for the protective function of Pot1 (show POT1 Antibodies) proteins.
Tumors from Acd(acd/acd) p53 (show TP53 Antibodies)(+/-) mice show a striking switch from the classic spectrum of p53 (show TP53 Antibodies)(-/-) mice toward carcinomas.
This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I.
POT1 and TIN2 organizing protein
, POT1 and TIN2-interacting protein
, TIN2 interacting protein 1
, adrenocortical dysplasia protein homolog
, adrenocortical dysplasia homolog (mouse)
, adrenocortical dysplasia protein