Browse our anti-ACD (ACD) Antibodies

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anti-Adrenocortical Dysplasia Homolog (Mouse) Antibodies (ACD)
On are 80 Adrenocortical Dysplasia Homolog (Mouse) (ACD) Antibodies from 12 different suppliers available. Additionally we are shipping ACD Kits (17) and ACD Proteins (8) and many more products for this protein. A total of 115 ACD products are currently listed.

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Top referenced anti-ACD Antibodies

  1. Human Monoclonal ACD Primary Antibody for IF, WB - ABIN395038 : Abreu, Aritonovska, Reichenbach, Cristofari, Culp, Terns, Lingner, Terns: TIN2-tethered TPP1 recruits human telomerase to telomeres in vivo. in Molecular and cellular biology 2010 (PubMed)
    Show all 5 references for 395038

  2. Human Monoclonal ACD Primary Antibody for IF, IHC (p) - ABIN566298 : Frank, Tran, Qu, Stohr, Segal, Xu: The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres. in PLoS genetics 2015 (PubMed)
    Show all 2 references for 566298

  3. Human Polyclonal ACD Primary Antibody for WB - ABIN2787610 : Hockemeyer, Palm, Else, Daniels, Takai, Ye, Keegan, de Lange, Hammer: Telomere protection by mammalian Pot1 requires interaction with Tpp1. in Nature structural & molecular biology 2007 (PubMed)

More Antibodies against ACD Interaction Partners

Mouse (Murine) Adrenocortical Dysplasia Homolog (Mouse) (ACD) interaction partners

  1. shelterin protein TIN2 (show TINF2 Antibodies) can protect chromosome ends as a TRF2 (show TERF2 Antibodies)-tethered TIN2 (show TINF2 Antibodies)/TPP1 (show TPP1 Antibodies)/POT1 (show POT1 Antibodies) complex that lacks a physical connection to TRF1 (show TERF1 Antibodies)

  2. Mouse hematopoietic stem cells are acutely sensitive to inactivation of the shelterin gene Acd.

  3. Tpp1 (show TPP1 Antibodies) is required for the protective function of Pot1 (show POT1 Antibodies) proteins.

  4. Tumors from Acd(acd/acd) p53 (show TP53 Antibodies)(+/-) mice show a striking switch from the classic spectrum of p53 (show TP53 Antibodies)(-/-) mice toward carcinomas.

Human Adrenocortical Dysplasia Homolog (Mouse) (ACD) interaction partners

  1. a novel ACD mutation(p.G223V)is detected; ACD is a novel gene involved in childhood pre-B acute lymphoblastic leukemia and may play a functional role in enhancing leukemia cell survival

  2. The data support a causal relationship between a TPP1 (show TPP1 Antibodies) mutation and bone marrow disorders in a family.

  3. Clustering of novel mutations in the POT1 (show POT1 Antibodies) binding domain of ACD was statistically higher (P = .005) in melanoma probands compared with population control individuals (n = 6785).

  4. Shelterin protein TPP 1 (show TPP1 Antibodies) interacts with hTERT and recruits hTERT onto the telomeres, suggesting that TPP 1 (show TPP1 Antibodies) might be involved in regulation of telomere shortening.

  5. POT1 (show POT1 Antibodies)-TPP1 (show TPP1 Antibodies) binds telomeric DNA in a coordinated manner to facilitate assembly of the nucleoprotein complexes into a state that is more accessible to enzymatic activity.

  6. Study shows that the OB-fold domain of the telomere-binding protein TPP1 (show TPP1 Antibodies) recruits telomerase to telomeres through an association with the telomerase reverse transcriptase TERT (show TERT Antibodies); data define a potential interface for telomerase-TPP1 (show TPP1 Antibodies) interaction required for telomere maintenance and implicate defective telomerase recruitment in telomerase-related disease.

  7. a paper that firstly reported cloning of human TTP1 (PTOP) and its biological function at telomere. TPP1 (show TPP1 Antibodies) interacts with both POT1 (show POT1 Antibodies) and TIN2 (show TINF2 Antibodies), heterodimerizes with POT1 (show POT1 Antibodies) and regulates POT1 (show POT1 Antibodies) telomeric recruitment and telomere length.

  8. The presence of dysfunctional telomeres in chronic lymphocytic leukemia did not correlate with telomere shortening or chromatin marks deregulation but with a down-regulation of 2 shelterin genes: ACD and TINF2 (show TINF2 Antibodies).

  9. Results support a model in which POT1 (show POT1 Antibodies)-TPP1 (show TPP1 Antibodies) enhances telomerase processivity in a manner markedly different from the sliding clamps used by DNA polymerases.

  10. TIN2 (show TINF2 Antibodies)-anchored TPP1 (show TPP1 Antibodies) plays a major role in the recruitment of telomerase to telomeres in human cells.

ACD Antigen Profile

Antigen Summary

This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I.

Alternative names and synonyms associated with ACD

  • adrenocortical dysplasia homolog (mouse) (ACD) antibody
  • adrenocortical dysplasia homolog (mouse) (Acd) antibody
  • adrenocortical dysplasia (Acd) antibody
  • adrenocortical dysplasia homolog (LOC100346875) antibody
  • ACD antibody
  • PIP1 antibody
  • PTOP antibody
  • TINT1 antibody
  • TPP1 antibody

Protein level used designations for ACD

POT1 and TIN2 organizing protein , POT1 and TIN2-interacting protein , TIN2 interacting protein 1 , adrenocortical dysplasia protein homolog , adrenocortical dysplasia homolog (mouse) , adrenocortical dysplasia protein

65057 Homo sapiens
307798 Rattus norvegicus
487931 Canis lupus familiaris
510353 Bos taurus
699230 Macaca mulatta
769451 Gallus gallus
497652 Mus musculus
100346875 Oryctolagus cuniculus
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