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A role for PGD2 (show PTGDS ELISA Kits) signals acting through PTGDR in suppression of intestinal tumors.
Data indicate a PLA2G3 (show PLA2G3 ELISA Kits)-lipocalin (show APOD ELISA Kits)-type PGD2 synthase (L-PGDS)-PGD2 (show PTGDS ELISA Kits) receptor DP1 loop that drives mast cell maturation.
PGD(2)-DP signaling reduces vascular permeability both in vivo.
platelet DP1 (show REEP5 ELISA Kits) is not present in mice. Despite this, DP1 (show REEP5 ELISA Kits) deletion in mice augmented aneurysm formation and the hypertensive response to Ang II (show AGT ELISA Kits) and accelerated atherogenesis and thrombogenesis.
The present study demonstrates that functional roles of PGD2 and its receptors appear to depend on the nature of the inflammation in chronic skin inflammation, chronic contact hypersensitivity and IgE-mediated chronic allergic skin inflammation
After epicutaneous sensitization with ovalbumin (show OVA ELISA Kits) (OVA), DP activation inhibits the migration of Langerhans cells (LC)s and affects the priming of antigen-specific T cells in the draining lymph nodes.
pain sensitivity was increased in prostaglandin D receptor mutant mice
PGD2 (show PTGDS ELISA Kits) markedly augments disease activity through its ability to enhance the proinflammatory actions of macrophages and subsequent neutrophil activation.
Non-obligatory role of prostaglandin D2 receptor subtype 1 in rosacea: laropiprant in comparison to a placebo did not alleviate the symptoms of erythematoelangiectaic rosacea
EP2 receptors exhibit more constraints to mutations than DP receptors.
Low DP1 prostanoid receptor is associated with gastric cancer progression.
Lipocalin (show APOD ELISA Kits)-type prostaglandin D2 (PGD2) synthase (L-PGDS) interacts intracellularly with the G protein-coupled receptor (show ADRA1A ELISA Kits) DP1 in an agonist-independent manner.
the PTGDR -549 C/T polymorphism confers susceptibility to asthma in Europeans and adults. However, no association was found between the PTGDR 441 C/T and -197 C/T polymorphisms or the CCC and TCT (show TRPM7 ELISA Kits) haplotypes and asthma susceptibility.
PGD(2)-DP signaling reduces vascular permeability via endothelial cAMP/PKA/Tiam1/Rac1 pathway.
The PTGDR -441C/T polymorphism is not associated with asthma or its phenotypes in the North Indian population.
DP receptors amplify the biological response to CRTH2 (show PTGDR2 ELISA Kits) activation and the CRTH2 (show PTGDR2 ELISA Kits)/DP heteromer might represent both a functional signaling unit for PGD(2) and a potential target for development of heteromer-directed therapy for allergic diseases
Genetic combinations described have functional implications in the PTGDR promoter activity by changing the transcription factors affinity that will help characterize different risk groups.
The protein encoded by this gene is a G-protein-coupled receptor. It has been shown to function as a prostanoid DP receptor. The activity of this receptor is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+. Knockout studies in mice suggest that the ligand of this receptor, prostaglandin D2 (PGD2), functions as a mast cell-derived mediator to trigger asthmatic responses.
prostaglandin D2 receptor (DP)
, prostaglandin D2 receptor
, PGD receptor
, PGD2 receptor
, prostanoid DP receptor
, prostaglandin D receptor
, prostaglandin D2 receptor-like
, Prostanoid DP receptor