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PAX8 has a cell specific role in governing proliferation and migration in nontransformed ovarian surface epithelium cells compared to the oviductal cells, but its reduction in serous cancer cell lines provides a common mechanism for reducing cell survival.
findings proved that iodinated TG in thyroid follicular lumen regulated TTF-1 and PAX8 expression through thyroid stimulating hormone/thyroid stimulating hormone receptor (TSH/TSHR) mediated cAMP-PKA and PLC-PKC signaling pathways.
Case Report: primary seminal vesicle carcinoma strong and diffuse nuclear labeling for PAX8.
PAX8 is expressed in both benign and malignant mesothelium, and that BAP1 (show RNF2 ELISA Kits) loss is highly specific for malignant peritoneal neoplasms, in the differential with both benign mesothelial proliferations and ovarian serous tumors.
findings point to significant PTC (show F9 ELISA Kits)-associated dysregulation of several PAX8 target genes, supporting the notion that PAX8-regulated molecular cascades play important roles during thyroid tumorigenesis
we replicated one known signal in PAX8 (2.6 minutes per allele, 95% CI [1.9, 3.2], P = 5.7x10-16) and identified and replicated two novel associations at VRK2 (show VRK2 ELISA Kits) (2.0 minutes per allele, 95% CI [1.3, 2.7], P = 1.2x10-9; and 1.6 minutes per allele, 95% CI [1.1, 2.2], P = 7.6x10-9)
Putative PAX8 target genes are enriched for common serous epithelial ovarian cancer risk variants.
We conclude that PAX8 immunostain is negative in most cervical cell carcinomas and is less frequently expressed in endocervical adenocarcinomas as compared with the previously reported high sensitivity for ovarian and endometrial adenocarcinomas
Study postulated that both TTF-1 (show NKX2-1 ELISA Kits) and PAX-8 when co-expressed and have anti-proliferative and anti-tumorigenic properties up to a threshold expression level and beyond that, are able to induce pro-tumorigenic effects in thyroid carcinomas.
Direct sequencing of the PAX8 gene revealed a novel single nucleotide substitution (c.162 A>T) in exon 2 that resulted in the substitution of the normal serine 54 with a cysteine (S54C), which segregated with elevated serum TSH levels.
Pax8 is required for cell proliferation of pronephric precursors and regulates the expression of hnf1b (show HNF1B ELISA Kits) and wnt (show WNT2 ELISA Kits) pathway genes in the kidney field.
nephrogenic transcription factors (osr1 (show OSR1 ELISA Kits), osr2, hnf1b (show HNF1B ELISA Kits), lhx1 (show LHX1 ELISA Kits), pax8)play important role in nephrogenesis but have no pronephros induction potential upon overexpression; they activate transcription cascades reflecting activation by activin A (show INHBA ELISA Kits), retinoic acid
These results suggest that Pax8 maybe the downstream molecule of ALK3 (show BMPR1A ELISA Kits), it mediates the murine heart development via cellular senescence, which may serve as a mechanism that compensates for the cell loss via apoptosis in heart development.
Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure
PAX8 protein expression was associated with germinal layers in human and murine forebrain and hindbrain development.
Pax8 is essential for function and survival of adult thyroid cells.
a core regulatory subcircuit composed of Pax2 (show PAX2 ELISA Kits)/8, Gata3 (show GATA3 ELISA Kits) and Lim1 (show LHX1 ELISA Kits) turns on a deeper layer of transcriptional regulators while activating effector genes responsible for cell signaling and tissue organization.
The Pax8 promoter appears to be autoregulated, a feature that might be responsible for the haploinsufficiency displayed by this gene.
Inducible, Pax8-rtTA-based deletion of VHL (show VHL ELISA Kits) leads to organ-specific expression of epithelial HIF and erythropoietin (show EPO ELISA Kits) in liver and kidney without causing pathological changes.
study concludes that Cadherin-16 is a novel downstream target of the transcription factor Pax8, likely since the early steps of thyroid development, and that its expression is associated with the fully differentiated state of the thyroid cell
a thyroid-specific regulatory element in the 5' upstream region of the Pax8 gene
Pax2a and Pax8 regulate cell differentiation during sensory placode formation
pax8 works with related genes pax2a/pax2b to downregulate otic expression of foxi1 (show FOXI1 ELISA Kits), a necessary step for further otic development
evolutionary links between jaw and ear formation can be traced to Fgf-Foxi1 (show FOXI1 ELISA Kits)-Pax8 pathways
Pax2a and Pax8 are the main effectors downstream of Fgf signals in ear formation
pax8 is initially required for normal otic induction, and subsequently pax8, pax2a and pax2b act redundantly to maintain otic fate
This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described.
paired box 8
, paired box gene 8
, paired box protein Pax-8
, paired domain gene 8
, Pax-8 protein
, Pax-8 DNA-binding transcription factor