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findings proved that iodinated TG in thyroid follicular lumen regulated TTF-1 and PAX8 expression through thyroid stimulating hormone/thyroid stimulating hormone receptor (TSH/TSHR) mediated cAMP-PKA and PLC-PKC signaling pathways.
The genetic or epigenetic inactivation of NKX2-1/TTF-1 (show NKX2-1 Proteins) may play an essential role in the development and aberrant differentiation of non-TRU-type lung adenocarcinomas.
Studied the prognostic relevance of thyroid transcription factor 1 (TTF1 (show NKX2-1 Proteins)) copy number alterations (CNAs) and expression levels in non-small cell lung cancer; found TTF1 (show NKX2-1 Proteins) CNAs and expression high within tumors and between primary and metastatic tumors.
our findings show that miR (show MLXIP Proteins)-532-5p is a novel transcriptional target of TTF-1 (show NKX2-1 Proteins) that plays a tumor suppressive role by targeting KRAS and MKL2 (show MKL2 Proteins) in lung adenocarcinoma
Single nucleotide polymorphism in TTF1 (show NKX2-1 Proteins) gene is associated with Systemic lupus erythematosus
it may be useful to combine NAPA (show NAPA Proteins) and TTF-1 (show NKX2-1 Proteins) for increased sensitivity in lung cancer diagnostics. There is no substantial difference between monoclonal and polyclonal p40 (show IL9 Proteins) and between different NAPA (show NAPA Proteins) clones, whereas there is a difference between the TTF-1 (show NKX2-1 Proteins) clones 8G7G3/1 and SPT24
Because TTF-1 (show NKX2-1 Proteins) is not detected in the vast majority of cases using a separate antibody clone, 8G7G3/1, we conclude that aberrant staining is due to cross-reactivity to unknown antigen(s). TTF-1 (show NKX2-1 Proteins) positivity and even Napsin A (show NAPSA Proteins) positivity, therefore, cannot be used as conclusive evidence of pulmonary origin and gastrointestinal origin must be considered in the differential diagnosis
TTF-1 (show NKX2-1 Proteins) immunoreactivity was seen in 19 pulmonary neuroendocrine carcinoma (PNEC) cases (95%) and 13 thymic (TNEC) cases (59.1%). TTF-1 (show NKX2-1 Proteins) positivity was associated with high sensitivity but low specificity for PNEC, and adding PAX8 (show PAX8 Proteins) negativity significantly increased the specificity. PAX8 (show PAX8 Proteins) positivity alone showed essentially 100% specificity and 86.4% sensitivity for TNEC.
TTF-1 (show NKX2-1 Proteins) positivity does not exclude the diagnosis of primary Olfactory neuroblastoma (show ARHGEF16 Proteins), although usually only a small percentage of cells are positive.
TTF1 (show NKX2-1 Proteins)-expression had no significant impact on outcomes after irradiation of limited-disease small cell lung cancer.
this study shows that in a mouse model of thyrocyte hyperplasia, proliferating thyrocytes were thyroid transcription factor (TTF1 (show NKX2-1 Proteins))-positive
TTF-1 (show NKX2-1 Proteins) is expressed in lung during different stages of development.
Interaction of TTF-I with target sites upstream and downstream of the rDNA transcription unit connects these distal DNA elements by forming a chromatin loop between the rDNA promoter and the terminators.
ErbB4 is a critical upstream regulator of TTF-1 in type II epithelial cells and that this interaction is important for Sftpb regulation.
Otp and TTF-1 (show NKX2-1 Proteins) are essential for the normal morphological development of the hypothalamus, including the arcuate nucleus [review]
Depletion of TTF-I recapitulates the effects of ARF on ribosomal RNA synthesis and is rescued by the introduction of a TTF-I transgene.
This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression.
transcription termination factor 1
, RNA polymerase I termination factor
, transcription termination factor I