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this study shows that in a mouse model of thyrocyte hyperplasia, proliferating thyrocytes were thyroid transcription factor (TTF1 (show NKX2-1 Proteins))-positive
TTF-1 (show NKX2-1 Proteins) is expressed in lung during different stages of development.
Interaction of TTF-I with target sites upstream and downstream of the rDNA transcription unit connects these distal DNA elements by forming a chromatin loop between the rDNA promoter and the terminators.
ErbB4 is a critical upstream regulator of TTF-1 in type II epithelial cells and that this interaction is important for Sftpb regulation.
Otp and TTF-1 (show NKX2-1 Proteins) are essential for the normal morphological development of the hypothalamus, including the arcuate nucleus [review]
Depletion of TTF-I recapitulates the effects of ARF on ribosomal RNA synthesis and is rescued by the introduction of a TTF-I transgene.
TTF-1 (show NKX2-1 Proteins) immunoreactivity was seen in 19 pulmonary neuroendocrine carcinoma (PNEC) cases (95%) and 13 thymic (TNEC) cases (59.1%). TTF-1 (show NKX2-1 Proteins) positivity was associated with high sensitivity but low specificity for PNEC, and adding PAX8 (show PAX8 Proteins) negativity significantly increased the specificity. PAX8 (show PAX8 Proteins) positivity alone showed essentially 100% specificity and 86.4% sensitivity for TNEC.
TTF-1 (show NKX2-1 Proteins) positivity does not exclude the diagnosis of primary Olfactory neuroblastoma (show ARHGEF16 Proteins), although usually only a small percentage of cells are positive.
TTF1 (show NKX2-1 Proteins)-expression had no significant impact on outcomes after irradiation of limited-disease small cell lung cancer.
Thyroid Transcription Factor 1 (show NKX2-1 Proteins) Alters the Expression Profiles of Cytokine and Angiogenic Factors of Lung Cancer Cells.
Study showed that TTF1 (show NKX2-1 Proteins) expression was upregulated in tumor tissues from patients with hepatocellular carcinoma (HCC (show FAM126A Proteins)) and that TTF1 (show NKX2-1 Proteins) mRNA levels were significantly associated with poor prognoses. Moreover, upregulation of TTF1 (show NKX2-1 Proteins) was shown to promote the proliferation of HCC (show FAM126A Proteins) cells in vitro.
TTF-1 (show NKX2-1 Proteins) shows significant potential as a diagnostic marker to differentiate metastatic pulmonary from non-pulmonary adenocarcinomas in pleural or other effusions.
P-AKT (show AKT1 Proteins) and TTF-1 (show NKX2-1 Proteins) using IHC had statistically significant correlation with EGFR (show EGFR Proteins) mutation with high negative predictive value
Case Report: KRAS mutation-positive bronchial surface epithelium type lung adenocarcinoma with strong expression of TTF-1 (show NKX2-1 Proteins).
Overexpression of Transcription Termination Factor 1 is Associated with Colorectal Cancer
CK7 (show KRT7 Proteins), TTF-1 (show NKX2-1 Proteins) and napsin A (show NAPSA Proteins) are predominantly expressed in primary lung adenocarcinoma patients, with CDX-2 (show CDX2 Proteins) being inconsistently expressed.
This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression.
, homeobox protein Nkx-2.1
, thyroid nuclear factor 1
, thyroid transcription factor 1 TTF-1 NK-2
, RNA polymerase I termination factor
, transcription termination factor 1
, transcription termination factor I