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Rabbit ''B'' (1-2 Lbs.) Complement (Lyophilized) With Diluent

Host: Rabbit
Catalog No. ABIN925152
  • Host
    Rabbit
    Specificity
    The complement system consists of a number of small proteins found in the blood, generally synthesized by the liver, and normally circulating as inactive precursors (pro-proteins). When stimulated by one of several triggers, proteases in the system cleave specific proteins to release cytokines and initiate an amplifying cascade of further cleavages. The end-result of this activation cascade is massive amplification of the response and activation of the cell-killing membrane attack complex. Over 25 proteins and protein fragments make up the complement system, including serum proteins, serosal proteins, and cell membrane receptors. They account for about 5% of the globulin fraction of blood serum.
    Characteristics
    Strain: Rabbit - New Zealand White
    Sex: Mixed
    Purification
    Complement
    Sterility
    Non-sterile
    Components
    with Diluent
  • Application Notes
    pH: normal Immunoelectrophoresis: normal Hemoglobin: normal IgG Concentration: normal Immunoelectrophoresis: normal
    Comment

    The rabbit complement system helps or “complements” the ability of antibodies and phagocytic cells to clear pathogens from an organism. Complement is part of the innate immune system that is not adaptable and does not change over the course of an individual's lifetime. Complement can be recruited and brought into action by the adaptive immune system. The following are basic functions of complement: 1. Opsonisation - enhancing phagocytosis of antigens 2. Chemotaxis - attracting macrophages and neutrophils 3. Cell Lysis - rupturing membranes of foreign cells 4. Clumping of antigen-bearing agents

    Restrictions
    For Research Use only
  • Format
    Frozen
    Reconstitution
    Reconstitution Buffer: Restore with deionized water (or equivalent), Reconstitution Volume: 5.0 mL
    Concentration
    85 mg/mL
    Handling Advice
    Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. COMPLEMENT IS A TEMPERATURE SENSITIVE PRODUCT. IMPROPER STORAGE WILL INACTIVATE COMPLEMENT ACTIVITY.
    Storage
    4 °C
    Expiry Date
    12 months
  • Background
    The rabbit complement system helps or “complements” the ability of antibodies and phagocytic cells to clear pathogens from an organism. Complement is part of the innate immune system that is not adaptable and does not change over the course of an individual's lifetime. Complement can be recruited and brought into action by the adaptive immune system. The following are basic functions of complement: 1. Opsonisation - enhancing phagocytosis of antigens 2. Chemotaxis - attracting macrophages and neutrophils 3. Cell Lysis - rupturing membranes of foreign cells 4. Clumping of antigen-bearing agents
    Synonyms: Complement system, tissue macrophages, blood monocytes, protease C3-convertase, mannose-binding lectin pathway, C3, C3a, C3b, C5a, C5b, C6, C7, C8, and polymeric C9, cascade cleavage and activation events, recruit inflammatory cells, anaphylatoxin.
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