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Aminolevulinate, delta-, Synthase 2 ELISA Kits (ALAS2)
On are 1 Aminolevulinate, delta-, Synthase 2 (ALAS2) ELISA Kits from 1 different suppliers available. Additionally we are shipping ALAS2 Antibodies (71) and ALAS2 Proteins (5) and many more products for this protein. A total of 83 ALAS2 products are currently listed.
ALAS, Alas-2, alas-e, ALASE, ANH1, ASB, cb1063, sau, sauternes, XLDPP, XLEPP, XLSA
list all ELISA KIts Gene Name GeneID UniProt
ALAS2 212 P22557
Rat ALAS2 ALAS2 25748 Q63147
Mouse ALAS2 ALAS2 11656 P08680

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ALAS2 (ALAS2) ELISA Kits by Reactivity

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More ELISA Kits for ALAS2 Interaction Partners

Human Aminolevulinate, delta-, Synthase 2 (ALAS2) interaction partners

  1. a case of X-linked sideroblastic anemia caused by a novel homozygous deletional mutation in exon 10 of ALAS2 gene is presented

  2. int-1 (show WNT1 ELISA Kits)-GATA (show QRSL1 ELISA Kits) site should be examined in patients with XLSA in clinical settings when no known mutation is found in ALAS2 exons.

  3. From pH jump experiments, comparable rates for the denaturation of the tertiary structure and PLP (show PLP1 ELISA Kits)-microenvironment were discerned, indicating that the catalytic active site geometry strongly depends on the stable tertiary structural organization. Lastly, we demonstrate that partially folded ALAS tends to self-associate into higher oligomeric species at moderate GuHCl concentrations.

  4. data indicate that the X-linked protoporphyria (show FECH ELISA Kits) variants possess enhanced ALAS activity and ALA dissociation rates, as well as distinct structural properties from those of wild-type hALAS

  5. In this article we add a novel mutation to the previously described 61 different ALAS2 mutations identified in X-linked sideroblastic anaemia patients.

  6. the primary deficiency in ferrochelatase (show FECH ELISA Kits) leads to a secondary increase in ALAS2 expression.

  7. The ALAS2 Y365C mutation impairs pyridoxal 5'-phosphate binding to ALAS2, destabilizing the enzyme. X inactivation was not highly skewed in WBC from affected women. This X-linked dominant mutation perturbs erythropoiesis via cell-nonautonomous effects.

  8. the 130-base pair enhancer region located in the first intron of the ALAS2 gene should be examined in patients with congenital sideroblastic anemia in whom the gene responsible is unknown.

  9. 5 families with X-linked sideroblastic anemia had mutations in a GATA (show QRSL1 ELISA Kits) transcription factor binding site located in a transcriptional enhancer element in intron 1 of the ALAS2 gene.

  10. Loss-of-function FECH (show FECH ELISA Kits) and gain-of-function erythroid-specific ALAS2 mutations causing erythropoietic protoporphyria (show FECH ELISA Kits) and x-linked protoporphyria (show FECH ELISA Kits) in North American patients reveal novel mutations and a high prevalence of X-linked protoporphyria (show FECH ELISA Kits).

Xenopus laevis Aminolevulinate, delta-, Synthase 2 (ALAS2) interaction partners

  1. Xalas2 might be able to synthesize hemoglobin (show HBB ELISA Kits) during hematopoiesis and mediate erythrocyte differentiation by regulating hba3 expression in Xenopus laevis

Mouse (Murine) Aminolevulinate, delta-, Synthase 2 (ALAS2) interaction partners

  1. We propose that the N-terminal truncation offers a cell-specific ALAS2 regulatory mechanism without hindering heme synthesis

  2. Light treatments revealed that ALAS2 expression results in an increase in cell death in comparison to aminolevulinic acid (ALA) treatment producing a similar amount of protoprophyrin IX.

  3. The rate of ALA release is also controlled by a hysteretic kinetic mechanism (observed as a lag (show STMN1 ELISA Kits) in the ALA external aldimine formation progress curve), consistent with conformational changes governing the dissociation of ALA from ALAS.

  4. impaired mitochondrial [Fe-S] cluster biogenesis in Mfrn1 (show SLC25A37 ELISA Kits)(gt/gt (show FABP6 ELISA Kits)) cells results in elevated IRP1 (show ACO1 ELISA Kits) RNA-binding that attenuates ALAS2 mRNA translation and protoporphyrin accumulation

  5. Aberrant iron accumulation and peroxidized state of (ALAS2)-deficient definitive erythroblasts

  6. Gene expression and enzymatic assays indicate that erythroid 5-aminolevulinic acid synthase (show ALAS1 ELISA Kits) (Alas2) is decreased in hem6 animals, suggesting a mechanism that could account for the anemia.

ALAS2 Antigen Profile

Antigen Summary

The product of this gene specifies an erythroid-specific mitochondrially located enzyme. The encoded protein catalyzes the first step in the heme biosynthetic pathway. Defects in this gene cause X-linked pyridoxine-responsive sideroblastic anemia. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with ALAS2

  • aminolevulinate, delta-, synthase 2 (alas2) Elisa Kit
  • aminolevulinate, delta-, synthase 2 (ALAS2) Elisa Kit
  • aminolevulinate, delta-, synthase 2 (Alas2) Elisa Kit
  • aminolevulinate, delta-, synthetase 2 (alas2) Elisa Kit
  • aminolevulinic acid synthase 2, erythroid (Alas2) Elisa Kit
  • ALAS Elisa Kit
  • Alas-2 Elisa Kit
  • alas-e Elisa Kit
  • ALASE Elisa Kit
  • ANH1 Elisa Kit
  • ASB Elisa Kit
  • cb1063 Elisa Kit
  • sau Elisa Kit
  • sauternes Elisa Kit
  • XLDPP Elisa Kit
  • XLEPP Elisa Kit
  • XLSA Elisa Kit

Protein level used designations for ALAS2

5-aminolevulinate synthase 2 , aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia) , 5-aminolevulinate synthase, erythroid-specific, mitochondrial , aminolevulinate, delta-, synthase 2 , ALAS-E , delta-ALA synthase 2 , 5-aminolevulinic acid synthase 2 , delta-aminolevulinate synthase 2 , 5-aminolevulinate synthase, erythroid-specific, mitochondrial-like , delta-ALA synthetase , delta-ALA synthetase 2 , Aminolevulinate synthase 2, delta , aminolevulinic acid synthase 2, erythroid , erythroid-specific delta-aminolevulinate synthase ALAS-E , erythroid aminolevulinate synthase , erythroid-specific ALAS

448773 Xenopus (Silurana) tropicalis
473626 Pan troglodytes
704727 Macaca mulatta
100060580 Equus caballus
100174709 Pongo abelii
100410919 Callithrix jacchus
100606858 Nomascus leucogenys
212 Homo sapiens
511791 Bos taurus
25748 Rattus norvegicus
447323 Xenopus laevis
491498 Canis lupus familiaris
64607 Danio rerio
11656 Mus musculus
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