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Ferrochelatase ELISA Kits (FECH)
On www.antibodies-online.com are 17 Ferrochelatase (FECH) ELISA Kits from 7 different suppliers available. Additionally we are shipping FECH Antibodies (52) and FECH Proteins (14) and many more products for this protein. A total of 91 FECH products are currently listed.
Synonyms:
AI894116, CG2098, Dmel\\CG2098, EPP, FCE, fch, Fcl, FECH, GB15952, zgc:109851
list all ELISA KIts Gene Name GeneID UniProt
FECH 2235 P22830
FECH 14151  
FECH 361338  

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More ELISA Kits for FECH Interaction Partners

Synechocystis PCC 6803 Ferrochelatase (FECH) interaction partners

  1. The plastidic type II ferrochelatase contains a C-terminal chlorophyll a/b (CAB (show NPDC1 ELISA Kits)) motif, a conserved hydrophobic stretch homologous to the CAB (show NPDC1 ELISA Kits) domain of plant light- harvesting proteins.

  2. The apparent surplus of FeCH activity in the wild type is critical for cell viability under high light due to a regulatory role of FeCH in the distribution of Chl (show CHRDL1 ELISA Kits) into apoproteins.

  3. Analysis of the recombinant full-length and truncated ferrochelatase (FeCH) demonstrated that the C-terminal extension is critical for activity of the FeCH and that it is strictly required for oligomerization of this enzyme.

Human Ferrochelatase (FECH) interaction partners

  1. In this study, QM/MM and quantum mechanical thermodynamic cycle perturbation free energy calculations were performed to investigate the porphyrin metalation in human ferrochelatase. It suggests a most reasonable pathway including the steps of the ferrous iron approaching from the site with Met76 coordinated and His263 playing the role of accepting proton.

  2. These findings suggest that homozygous polymorphism of the FECH gene is associated with a slight elevation of the protoporphyrin level in erythrocytes, resulting in a mild EPP phenotype

  3. a novel mutation, c.84G >A, in the FECH gene in four individuals with Erythropoietic Protoporphyria, is reported.

  4. High ferrochelatase expression is associated with growth of malarial parasites in erythropoietic protoporphyria patients.

  5. of ASO-V1 into developing human erythroblasts from an overtly EPP subject markedly increased the production of WT FECH mRNA and reduced the accumulation of PPIX to a level similar to that measured in asymptomatic EPP subjects

  6. Sequence analysis of the FECH gene identified a novel missense mutation in exon 4 (c.418>A, G140R) of the FECH gene, as well as the common FECH IVS3-48 polymorphism in erythropoietic protoporphyria.

  7. Loss-of-function FECH and gain-of-function erythroid-specific ALAS2 (show ALAS2 ELISA Kits) mutations causing erythropoietic protoporphyria and x-linked protoporphyria in North American patients reveal novel mutations and a high prevalence of X-linked protoporphyria.

  8. The mutation analysis in the FECH gene identified different genotypes with the t/t genotype, 7 with the t/M genotype, 14 with the c/t genotype and 10 with c/M genotype from different EPP families.

  9. Sequencing of the ferrochelatase gene did not show a mutation in any of the patients studied. Furthermore, the hypomorphic allele IVS3-48C was absent in all individuals.

  10. Molecular dynamic simulations provided insight into the conformational movements and function of the active site residues of human ferrochelatase.

Mouse (Murine) Ferrochelatase (FECH) interaction partners

  1. 5-aza-2'-deoxycytidine activates iron uptake and heme biosynthesis by increasing c-Myc (show MYC ELISA Kits) nuclear localization and binding to the E-boxes of transferrin receptor 1 (show TFR ELISA Kits) (TfR1 (show TFRC ELISA Kits)) and ferrochelatase (Fech) genes.

  2. analysis of the inhibitory metal ion-binding site in ferrochelatase

  3. Fech forms an oligomeric complex with Mfrn1 (show SLC25A37 ELISA Kits) and Abcb10 (show ABCB10 ELISA Kits) to synergistically integrate mitochondrial iron importation and use for heme biosynthesis.

  4. Ferrochelatase activity and protein levels were dramatically decreased in Irp2 (show IREB2 ELISA Kits)(-/-) spleens, whereas ferrochelatase mRNA levels were increased, demonstrating posttranscriptional regulation of ferrochelatase in vivo

  5. analysis of skin ferrochelatase and photosensitivity in mice and man

  6. exon 10-deleted ferrochelatase heterozygous mice exhibited skin photosensitivity but no liver disease

  7. analysis of the active site loop motif of murine ferrochelatase

  8. hydrogen bonding between ferrochelatase and mesoporphyrin is a key factor in the thermodynamics of the binding reaction

  9. Protoporphyric (Fech(m1pas)/Fech(m1pas) mice (C57BL/6J) showed a higher degree of liver pathology and more protoporphyrin accumulation than corresponding SJL/J and BALB/cJ mice. In the latter mice, mitochondrial respiratory chain activity was increased.

  10. The kinetic mechanisms of inhibition of two variants of ferrochelatase by N-methylprotoporphyrin are reported.

Pig (Porcine) Ferrochelatase (FECH) interaction partners

  1. the iron-removal reverse activity of FECH

FECH Antigen Profile

Antigen Summary

The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome 3.

Alternative names and synonyms associated with FECH

  • ferrochelatase (hemH) Elisa Kit
  • ATPase, aminophospholipid transporter, class I, type 8B, member 1 (ATP8B1) Elisa Kit
  • ferrochelatase (FECH) Elisa Kit
  • CG2098 gene product from transcript CG2098-RA (ferrochelatase) Elisa Kit
  • ferrochelatase, mitochondrial (ferrochelatase) Elisa Kit
  • ferrochelatase (hemH-2) Elisa Kit
  • ferrochelatase (hem15) Elisa Kit
  • ferrochelatase (fech) Elisa Kit
  • ferrochelatase (Fech) Elisa Kit
  • AI894116 Elisa Kit
  • CG2098 Elisa Kit
  • Dmel\\CG2098 Elisa Kit
  • EPP Elisa Kit
  • FCE Elisa Kit
  • fch Elisa Kit
  • Fcl Elisa Kit
  • FECH Elisa Kit
  • GB15952 Elisa Kit
  • zgc:109851 Elisa Kit

Protein level used designations for Ferrochelatase (FECH) ELISA Kits

ferrochelatase , ATPase, Class I, type 8B, member 1 , ferrochelatase (protoporphyria) , ferrochelatase, mitochondrial , CG2098-PA , CG2098-PB , CG2098-PC , ferrochelatase-PA , ferrochelatase-PB , ferrochelatase-PC , dracula , drc , frx , heme synthase , heme synthetase , protoheme ferro-lyase , protoporphyria

GENE ID SPECIES
954446 Synechocystis sp. PCC 6803
476190 Canis lupus familiaris
695759 Macaca mulatta
100173347 Pongo abelii
43757 Drosophila melanogaster
409922 Apis mellifera
1169771 Shewanella oneidensis MR-1
1171030 Shewanella oneidensis MR-1
1207904 Coxiella burnetii RSA 493
2539199 Schizosaccharomyces pombe 972h-
2799564 Listeria monocytogenes serotype 4b str. F2365
3192903 Ruegeria pomeroyi DSS-3
3232067 Campylobacter jejuni RM1221
3927345 Ehrlichia chaffeensis str. Arkansas
3931115 Anaplasma phagocytophilum str. HZ
3931832 Neorickettsia sennetsu str. Miyayama
58215 Danio rerio
398014 Xenopus laevis
374020 Gallus gallus
2235 Homo sapiens
610360 Canis lupus familiaris
790571 Bos taurus
14151 Mus musculus
361338 Rattus norvegicus
281158 Bos taurus
100322873 Sus scrofa
455437 Pan troglodytes
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