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Alternative splicing generates several isoforms of zneo1, most of which are developmentally regulated, showing distinct distribution in brain and other tissues
Results indicate that an efficient induction of hepcidin (show HAMP ELISA Kits) expression by hemojuvelin (HJV (show HFE2 ELISA Kits)) requires its interaction with neogenin.
Neogenin acts to synchronize neuroblast migration and terminal differentiation through the regulation of neuroblast cell cycle kinetics within the neurogenic microenvironment of the RMS.
these results highlight Neogenin1 as a novel downstream effector of the Sonic Hedgehog (show SHH ELISA Kits) pathway in medulloblastoma
Strong expression of RGMa (show RGMA ELISA Kits), RGMb (show RGMB ELISA Kits) and Neogenin protein was found on several major axon tracts such as the primary olfactory projections, anterior commissure and fasciculus retroflexus.
neogenin appears to suppress Myo (show SYNPO2 ELISA Kits) X movement on the basal side, but increases its movement towards the apical and dorsal side of a cell, promoting dorsal filopodium formation and growth
guidance receptor neogenin holds crucial importance for the propagation of an acute inflammatory response and further define mechanisms shared between the nervous and the immune system.
identification of neogenin-binding site on the repulsive guidance molecule A (show RGMA ELISA Kits)
these findings indicate that neogenin regulates SHH (show SHH ELISA Kits) signaling in the limb bud to achieve proper digit patterning.
Data show that neogenin influences neutrophil migration across endothelial HMEC-1 and alveolar A549 monolayers in vitro.
These findings show direct regulation of neogenin by the Rb/E2F3 pathway and demonstrate that regulation of neogenin expression is required for neural precursor migration.
The hemizygous 15q deletion unmasks the recessive functional polymorphism in NEO1 which plays a pivotal role in cortical interneuron development; study provides the first evidence linking NEO1 with autism spectrum disorders in humans
Neogenin influences both cadherin dynamics and junctional tension.
Ntn4 promotes the proliferation and motility of gastric cancer cells which is mediated by its receptor Neo and through further activation of multi-oncogenic pathways
The present study demonstrates that neogenin may be a tumor suppressor in breast cancer. Neogenin may serve as a potential diagnostic marker and therapeutic target for breast cancer.
These results show how repulsive guidance molecule acts as the central hub that links BMP2 (show BMP2 ELISA Kits) and NEO1 and physically connects these fundamental signaling pathways.
Neogenin expression is inversely associated with breast cancer grade.
high-expression of neogenin-1 promotes gastric cancer proliferation and motility
miR (show MLXIP ELISA Kits)-18a may regulate biological behavior of human glioblastoma cells by targeting neogenin.
two RGMB (show RGMB ELISA Kits) ectodomains conformationally stabilize the juxtamembrane regions of two NEO1 receptors in a pH-dependent manner.
This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants.
, neogenin 1
, neogenin homolog 1
, immunoglobulin superfamily DCC subclass member 2