Browse our anti-Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 (SLC11A2) Antibodies

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anti-Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 Antibodies (SLC11A2)
On www.antibodies-online.com are 91 Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 (SLC11A2) Antibodies from 14 different suppliers available. Additionally we are shipping Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 Kits (21) and Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 Proteins (3) and many more products for this protein. A total of 117 Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 products are currently listed.
Synonyms:
ATNRAMP2, cb426, DCT1, Dmt1, F8G22.4, F8G22_4, fa07b10, MGC138014, mk, Nramp2, NRAMP metal ion transporter 2, SLC11A2, van, wu:fa07b10, zgc:136699
list all antibodies Gene Name GeneID UniProt
SLC11A2 25715 O54902
SLC11A2 4891 P49281
SLC11A2 18174 P49282

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Top referenced anti-Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 Antibodies

  1. Mouse (Murine) Polyclonal SLC11A2 Primary Antibody for IF, WB - ABIN657723 : Rose, Behm, Drgon, Johnson, Uhl: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. in Molecular medicine (Cambridge, Mass.) 2010 (PubMed)
    Show all 5 references for 657723

  2. Human Monoclonal SLC11A2 Primary Antibody for IHC (p), ELISA - ABIN562043 : Foot, Dalton, Shearwin-Whyatt, Dorstyn, Tan, Yang, Kumar: Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. in Blood 2008 (PubMed)
    Show all 4 references for 562043

  3. Human Polyclonal SLC11A2 Primary Antibody for WB - ABIN2781546 : Nevo: Site-directed mutagenesis investigation of coupling properties of metal ion transport by DCT1. in Biochimica et biophysica acta 2008 (PubMed)

More Antibodies against Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 Interaction Partners

Pig (Porcine) Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 (SLC11A2) interaction partners

  1. Data suggest that maternal protein restriction during pregnancy and lactation influences growth of male and female offspring at weaning, reduces duodenum mucosal expression of iron transporters (DMT1 and FPN), and decreases serum Fe levels; serum ferritin (show FTL Antibodies) levels tend to be lower, yet serum transferrin is greatly higher in male weaning piglets. (FPN = solute carrier (show SERTAD2 Antibodies) family 40 [iron-regulated transporter (show SLC40A1 Antibodies)] member 1)

Zebrafish Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 (SLC11A2) interaction partners

  1. The zebrafish mutant gene chardonnay (cdy) encodes divalent metal transporter 1 (DMT1). Whereas wild-type zebrafish DMT1 protein can transport iron, the truncated protein expressed in cdy mutants is not functional.

Human Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 (SLC11A2) interaction partners

  1. These results suggest that the increased expression of DMT1 (show DMRT1 Antibodies) induces iron overload and iron overload induces osteoblast autophagy and apoptosis, thus affecting the pathological processes of osteoporosis. Clarifying the mechanisms underlying the effects of DMT1 (show DMRT1 Antibodies) will allow the identification of novel targets for the prevention and treatment of osteoporosis.

  2. the cellular iron importer, divalent metal transporter 1 (DMT1), is highly expressed in colorectal cancer through hypoxia-inducible factor 2alpha-dependent transcription.

  3. Divalent metal transporter-1 overexpression in endometriosis patients' endometrium can increase iron influx to endometrial cells, inducing oxidative stress-mediated proinflammatory signaling. In turn, endometriosis-related conditions, as iron overload and inflammation (IL-1beta (show IL1B Antibodies)), enhance endometriosis patients endometrial DMT1 (show DMRT1 Antibodies) expression, creating a vicious circle on DMT-1 (show DMRT1 Antibodies)-modulated pathways.

  4. X-ray crystallographic analysis of a 4-component complex comprising the VPS26 (show VPS26A Antibodies) & VPS35 (show vps35 Antibodies) subunits of retromer, sorting nexin SNX3 (show SNX3 Antibodies), & recycling signal from the divalent cation transporter DMT1 (show DMRT1 Antibodies)-II; analysis identifies a binding site for canonical recycling signals at the interface between VPS26 (show VPS26A Antibodies) & SNX3 (show SNX3 Antibodies); shows cooperative interactions among the VPS subunits, SNX3 (show SNX3 Antibodies) & cargo that couple signal-recognition to membrane recruitment.

  5. Gene silencing of either CTR1 (show SLC31A1 Antibodies) or DMT1 (show DMRT1 Antibodies) did not affect copper accumulation in cells, but deficiency in both CTR1 (show SLC31A1 Antibodies) and DMT1 (show DMRT1 Antibodies) resulted in a complete inhibition of copper uptake.

  6. These data suggest that iron uptake induces the production of ROS (show ROS1 Antibodies), which modify DMT1 (show DMRT1 Antibodies) endocytic cycling, thus changing the iron transport activity at the apical membrane.

  7. We propose that DMT1 (show DMRT1 Antibodies) deficiency negatively affects metabolism and life span of mature erythrocytes; two other aspects of defective erythropoiesis which contribute to the pathophysiology of the disease

  8. Suggest role for divalent cation transporter DMT1 (show DMRT1 Antibodies) in the entry of Hg(II) into the intestinal epithelium.

  9. Six months after RYGB surgery, patients exhibit an increase in DMT1 (show DMRT1 Antibodies) expression in the enterocytes of the tips of the villi at the proximal jejunum

  10. In Parkinson's disease, increased iron levels are associated with increased Ndfip1 (show NDFIP1 Antibodies) expression for the regulation of DMT1 (show DMRT1 Antibodies), including abnormal Ndfip1 (show NDFIP1 Antibodies) activation in non-neuronal cell types such as astrocytes.

Mouse (Murine) Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 (SLC11A2) interaction partners

  1. IL-6 (show IL6 Antibodies) likely up-regulates IRP1 (show ACO1 Antibodies) and DMT1 expression and down-regulates FPN1 (show SLC40A1 Antibodies) expression in BV2 (show DNAH9 Antibodies) microglial cells through JNK (show MAPK8 Antibodies) signaling pathways

  2. the cellular iron importer, divalent metal transporter 1 (DMT1), is highly expressed in colorectal cancer through hypoxia-inducible factor 2alpha-dependent transcription.

  3. Ndfip2 (show NDFIP2 Antibodies) controls DMT1 in the liver with female mice showing a greater response to altered dietary iron than the male mice

  4. PrP(C (show PRNP Antibodies)) promotes, and possibly regulates, the uptake of iron through DMT1 and Zip14 (show SLC39A14 Antibodies) via its ferrireductase activity.

  5. This study reveals a critical function for DMT1 in intestinal nonheme-iron absorption for normal growth and development, and that it is not required for the transport of copper, manganese, or zinc.

  6. We propose that DMT1 deficiency negatively affects metabolism and life span of mature erythrocytes; two other aspects of defective erythropoiesis which contribute to the pathophysiology of the disease

  7. Misregulation of DMT1 is implicated in Parkinson's disease.

  8. Suggest role for divalent cation transporter DMT1 in the entry of Hg(II) into the intestinal epithelium.

  9. The Cu uptake in HEK293 cells that over-expressed the 2/-IRE isoform of DMT1 transporter supports our earlier contention that DMT1 transports Cu as Cu(1+).

  10. Hepatocyte divalent metal-ion transporter-1 is dispensable for hepatic iron accumulation and non-transferrin (show Tf Antibodies)-bound iron uptake in mice.

Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 (SLC11A2) Antigen Profile

Antigen Summary

This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 2 (SLC11A2)

  • solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (SLC11A2) antibody
  • metal transporter NRAMP2 (NRAMP2) antibody
  • manganese transport protein (NRAMP2) antibody
  • NRAMP2 (ARALYDRAFT_891495) antibody
  • solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 (slc11a2) antibody
  • solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (slc11a2) antibody
  • solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 (Slc11a2) antibody
  • solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 (SLC11A2) antibody
  • solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (Slc11a2) antibody
  • ATNRAMP2 antibody
  • cb426 antibody
  • DCT1 antibody
  • Dmt1 antibody
  • F8G22.4 antibody
  • F8G22_4 antibody
  • fa07b10 antibody
  • MGC138014 antibody
  • mk antibody
  • Nramp2 antibody
  • NRAMP metal ion transporter 2 antibody
  • SLC11A2 antibody
  • van antibody
  • wu:fa07b10 antibody
  • zgc:136699 antibody

Protein level used designations for SLC11A2

divalent metal transporter 1 , natural resistance-associated macrophage protein 2 , manganese transport protein , NRAMP2 , solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 , cdy , chardonnay , nramp , DMT-1 , NRAMP 2 , Solute carrier family 11 member 2 (natural resistance-associated macrophage protein 2) , divalent cation transporter 1 , microcytic anemia, viable anaemia

GENE ID SPECIES
733595 Sus scrofa
751817 Gallus gallus
841127 Arabidopsis thaliana
5726598 Chlamydomonas reinhardtii
9327403 Arabidopsis lyrata subsp. lyrata
100144712 Xenopus (Silurana) tropicalis
451897 Pan troglodytes
486543 Canis lupus familiaris
512464 Bos taurus
678623 Danio rerio
693986 Macaca mulatta
25715 Rattus norvegicus
4891 Homo sapiens
18174 Mus musculus
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