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Human Monoclonal SLC11A2 Primary Antibody for IHC (p), ELISA - ABIN562043
Foot, Dalton, Shearwin-Whyatt, Dorstyn, Tan, Yang, Kumar: Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. in Blood 2008
Show all 4 Pubmed References
Mouse (Murine) Polyclonal SLC11A2 Primary Antibody for IF, WB - ABIN657723
Rose, Behm, Drgon, Johnson, Uhl: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. in Molecular medicine (Cambridge, Mass.) 2010
Show all 5 Pubmed References
Data suggest that maternal protein restriction during pregnancy and lactation influences growth of male and female offspring at weaning, reduces duodenum mucosal expression of iron transporters (DMT1 and FPN), and decreases serum Fe levels; serum ferritin (show FTL Antibodies) levels tend to be lower, yet serum transferrin is greatly higher in male weaning piglets. (FPN = solute carrier (show SERTAD2 Antibodies) family 40 [iron-regulated transporter (show SLC40A1 Antibodies)] member 1)
The zebrafish mutant gene chardonnay (cdy) encodes divalent metal transporter 1 (DMT1). Whereas wild-type zebrafish DMT1 protein can transport iron, the truncated protein expressed in cdy mutants is not functional.
celiac disease may unmask the contribution of the DMT1 (show DMRT1 Antibodies) IVS4+44C>A polymorphism to the risk of anemia.
These results suggest that the increased expression of DMT1 (show DMRT1 Antibodies) induces iron overload and iron overload induces osteoblast autophagy and apoptosis, thus affecting the pathological processes of osteoporosis. Clarifying the mechanisms underlying the effects of DMT1 (show DMRT1 Antibodies) will allow the identification of novel targets for the prevention and treatment of osteoporosis.
the cellular iron importer, divalent metal transporter 1 (DMT1), is highly expressed in colorectal cancer through hypoxia-inducible factor 2alpha-dependent transcription.
Divalent metal transporter-1 overexpression in endometriosis patients' endometrium can increase iron influx to endometrial cells, inducing oxidative stress-mediated proinflammatory signaling. In turn, endometriosis-related conditions, as iron overload and inflammation (IL-1beta (show IL1B Antibodies)), enhance endometriosis patients endometrial DMT1 (show DMRT1 Antibodies) expression, creating a vicious circle on DMT-1 (show DMRT1 Antibodies)-modulated pathways.
X-ray crystallographic analysis of a 4-component complex comprising the VPS26 (show VPS26A Antibodies) & VPS35 (show vps35 Antibodies) subunits of retromer, sorting nexin SNX3 (show SNX3 Antibodies), & recycling signal from the divalent cation transporter DMT1 (show DMRT1 Antibodies)-II; analysis identifies a binding site for canonical recycling signals at the interface between VPS26 (show VPS26A Antibodies) & SNX3 (show SNX3 Antibodies); shows cooperative interactions among the VPS subunits, SNX3 (show SNX3 Antibodies) & cargo that couple signal-recognition to membrane recruitment.
Gene silencing of either CTR1 (show SLC31A1 Antibodies) or DMT1 (show DMRT1 Antibodies) did not affect copper accumulation in cells, but deficiency in both CTR1 (show SLC31A1 Antibodies) and DMT1 (show DMRT1 Antibodies) resulted in a complete inhibition of copper uptake.
These data suggest that iron uptake induces the production of ROS (show ROS1 Antibodies), which modify DMT1 (show DMRT1 Antibodies) endocytic cycling, thus changing the iron transport activity at the apical membrane.
We propose that DMT1 (show DMRT1 Antibodies) deficiency negatively affects metabolism and life span of mature erythrocytes; two other aspects of defective erythropoiesis which contribute to the pathophysiology of the disease
Suggest role for divalent cation transporter DMT1 (show DMRT1 Antibodies) in the entry of Hg(II) into the intestinal epithelium.
Six months after RYGB surgery, patients exhibit an increase in DMT1 (show DMRT1 Antibodies) expression in the enterocytes of the tips of the villi at the proximal jejunum
IL-6 (show IL6 Antibodies) likely up-regulates IRP1 (show ACO1 Antibodies) and DMT1 expression and down-regulates FPN1 (show SLC40A1 Antibodies) expression in BV2 (show DNAH9 Antibodies) microglial cells through JNK (show MAPK8 Antibodies) signaling pathways
Ndfip2 (show NDFIP2 Antibodies) controls DMT1 in the liver with female mice showing a greater response to altered dietary iron than the male mice
PrP(C (show PRNP Antibodies)) promotes, and possibly regulates, the uptake of iron through DMT1 and Zip14 (show SLC39A14 Antibodies) via its ferrireductase activity.
This study reveals a critical function for DMT1 in intestinal nonheme-iron absorption for normal growth and development, and that it is not required for the transport of copper, manganese, or zinc.
We propose that DMT1 deficiency negatively affects metabolism and life span of mature erythrocytes; two other aspects of defective erythropoiesis which contribute to the pathophysiology of the disease
Misregulation of DMT1 is implicated in Parkinson's disease.
Suggest role for divalent cation transporter DMT1 in the entry of Hg(II) into the intestinal epithelium.
The Cu uptake in HEK293 cells that over-expressed the 2/-IRE isoform of DMT1 transporter supports our earlier contention that DMT1 transports Cu as Cu(1+).
Hepatocyte divalent metal-ion transporter-1 is dispensable for hepatic iron accumulation and non-transferrin (show Tf Antibodies)-bound iron uptake in mice.
This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.
divalent metal transporter 1
, natural resistance-associated macrophage protein 2
, manganese transport protein
, solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
, NRAMP 2
, Solute carrier family 11 member 2 (natural resistance-associated macrophage protein 2)
, divalent cation transporter 1
, microcytic anemia, viable anaemia