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Stamp1 and Stamp2 (show STEAP4 Proteins) play critical roles in adipogenesis, but through different mechanisms.
Over-expression of STEAP2 is associated with prostate cancer progression.
Data suggest that STAMP1 is required for prostate cancer growth.
cloning and characterization of STAMP1, which is expressed in both normal prostate and prostate neoplasms
STEAP2 is involved in the development of prostate cancer. As a cell-surface antigen (show CD53 Proteins), it is a potential diagnostic or therapeutic target in prostate cancer.
Expression of STAMP2 (show STEAP4 Proteins), a gene highly similar to STAMP1 (STEAP2), in prostate cancer cells significantly increases cell growth and colony formation suggesting that STAMP2 (show STEAP4 Proteins) may have a role in cell proliferation.
The murine ortholog, Steap2, is a ferrireductase, cupric reductase, and stimulates cellular uptake of both iron and copper in vitro.
This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
, six-transmembrane epithelial antigen of prostate 2
, SixTransMembrane Protein of Prostate 1
, prostate cancer associated protein 1
, prostate cancer-associated protein 1
, protein up-regulated in metastatic prostate cancer
, protein upregulated in metastatic prostate cancer
, six transmembrane epithelial antigen of prostate 2
, six transmembrane epithelial antigen of the prostate 2