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Chicken Polyclonal Primary Antibody for WB - ABIN610608
Hunt, Morimoto: Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70. in Proceedings of the National Academy of Sciences of the United States of America 1985
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T, cooperatively with WNT (show WNT2 Antibodies) signaling, controls the progenitor state and the switch toward the mesodermal fate. Sox2 (show SOX2 Antibodies) acts antagonistically and promotes neural development.
Wnt3a (show WNT3A Antibodies), which regulate cell growth, were also expressed strongly during E12.5-E13.5. On the other hand, cleft formation and branching morphogenesis was suppressed by knockdown of Brachyury (show TBX1 Antibodies) gene, suggesting that Brachyury (show TBX1 Antibodies) plays a central role in regulating cell growth and cleft formation in early-stage embryonic mouse salivary gland development
Epiblast stem cells are discriminated by the expression of a specific marker T (Brachyury (show TBX1 Antibodies)) into two populations.
data confirmed that Brachyury (show TBX1 Antibodies) might contribute to hypoxia-induced EMT (show ITK Antibodies) of breast cancer and trigger HIF-1alpha (show HIF1A Antibodies) expression via PTEN (show PTEN Antibodies)/Akt (show AKT1 Antibodies) signaling
Results showed that the expression levels of HDAC1 (show HDAC1 Antibodies) and 3 are decreased gradually during embryonic stem cells (ESCs (show NR2E3 Antibodies)) mesodermal differentiation and interact physically with Bry protein, which is critical for mesodermal lineage commitment.
Epithelial-to-mesenchymal transition (EMT (show ITK Antibodies)) initiates the controlled differentiation of embryonic stem cells, which is both fuelled and terminated by the action of brachyury (show TBX1 Antibodies), whose expression is dependent on the EMT (show ITK Antibodies) and beta-catenin (show CTNNB1 Antibodies) activity.
results thus chart a comprehensive map of the Brachyury (show TBX1 Antibodies)-mediated gene-regulatory network and how it influences in vivo developmental homeostasis and coordination
T (BRACHYURY (show TBX1 Antibodies)), a classical and conserved mesodermal factor, was essential for robust activation of Blimp1 (show PRDM1 Antibodies) and Prdm14 (show PRDM14 Antibodies), two of the germline determinants.
In vivo knockdown of Brachyury (show TBX1 Antibodies) results in skeletal defects and urorectal malformations resembling caudal (show CAD Antibodies) regression syndrome
UTX (show KDM6A Antibodies) controls mesoderm differentiation and Brachyury (show TBX1 Antibodies) expression independent of H3K27 demethylase (show MBD2 Antibodies) activity; UTX (show KDM6A Antibodies) and UTY (show UTY Antibodies) are functionally redundant in ES cell differentiation and early embryonic development
DN-Xbra inhibits PV.1 expression and that the suppression of PV.1 reduces overall BMP signaling by inducing chordin (show CHRD Antibodies) and goosecoid expression.
EphA4-dependent Brachyury (show TBX1 Antibodies) expression is required for dorsal mesoderm involution in the Xenopus gastrula.
This is the first report to demonstrate that Brachyury (show TBX1 Antibodies) might affect the cytoskeletal structure through regulating the expression of an intermediate filament protein (show INA Antibodies), vimentin.
Data suggest a dual regulation in which XESR5 produces a competent area for mesoderm formation by suppressing the gene expression of XESR1 (show ESR1 Antibodies), while XESR1 (show ESR1 Antibodies) sharpens the boundary of Xbra expression.
controls the early homeobox (show PRRX1 Antibodies) gene expression domain in the animal-vegetal direction
findings reveal that the N-terminal domain that restricts the inducing activity of Xbra interacts with Smad1 (show SMAD1 Antibodies)
Embryo elongation can occur through the synergistic effect(s) of the organizer molecule chordin (show CHRD Antibodies), and the 'verall posteriorizing molecule Xbra.
AP-2rep (show KLF12 Antibodies) is involved in the morphogenesis of the mesoderm at the gastrula stage, via the brachyury (show TBX1 Antibodies) and/or Wnt (show WNT2 Antibodies) pathways.
rs2305089 variant in T (brachyury (show TBX1 Antibodies)) gene is associated with response to therapy in Spinal column chordoma.
Brachyury (show TBX1 Antibodies) was significantly associated with estrogen receptor (show ESR1 Antibodies) positive and human epidermal growth factor receptor (show EGFR Antibodies) 2 negative status; further study would be needed to clarify how it affects treatment prognosis.
Brachyury (show TBX1 Antibodies) is a candidate marker for predicting the clinical efficacy of tamoxifen.
Overexpression of Brachyury (show TBX1 Antibodies) in the cytoplasm is predictive of poor prognosis in gastrointestinal stromal tumors.
Results showed that the high expression of SMC1 (show SMC1A Antibodies) often promoted epithelial-mesenchymal transition, accompanied by the enhanced expression of Brachyury (show TBX1 Antibodies) in triple-negative breast cancer cells.
Brachyury (show TBX1 Antibodies) expression promotes lung cancer cell proliferation and invasion, and correlates with reduced patient survival.
Nuclear brachyury (show TBX1 Antibodies) expression is prevalent in embryonal carcinoma, seminoma, and small cell carcinoma of the lung but very rare in common carcinomas, sarcomas, and melanoma.
Elevated Brachyury (show TBX1 Antibodies) facilitates hepatocellular carcinoma metastasis by promoting EMT (show ITK Antibodies) via PTEN (show PTEN Antibodies)/Akt (show AKT1 Antibodies)/Snail (show SNAI1 Antibodies)-dependent pathway.
we found that Brachyury (show TBX1 Antibodies) expression was inversely correlated with CCL2 (show CCL2 Antibodies) and CCL4 (show CCL4 Antibodies) expression in human lung tumors
Brachyury (show TBX1 Antibodies) plays an important role in regulating TGF beta 1 (show TGFB1 Antibodies)-mediated renal epithelial mesenchymal transition and could be an attractive target for progression of renal disease therapies
The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. Two transcript variants encoding different isoforms have been found for this gene.
, brachyury-like 2
, brachyury-like 3
, low ratio
, protein T
, brachyury homolog
, T, brachyury homolog a
, brachyury (T)
, T brachyury homolog
, T brachyury protein