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Lack of DVL (show DVL2 ELISA Kits) prevents NEK2 (show NEK2 ELISA Kits)-controlled dissolution of loose centrosomal linker and subsequent centrosomal separation. Increased DVL (show DVL2 ELISA Kits) levels, in contrast, sequester centrosomal NEK2 (show NEK2 ELISA Kits) and mimic monopolar spindle defects induced by a dominant negative version of this kinase.
These results identify USP4 (show USP4 ELISA Kits) as a novel regulator of Dvl (show DVL2 ELISA Kits) in Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signal and show its involvement in Wnt3a (show WNT3A ELISA Kits)-induced osteoblast differentiation
Authors conclude that the planar cell polarity (PCP (show PRCP ELISA Kits)) pathway contributes significantly to the motility and hence the invasiveness of glioblastoma multiforme (GBM) cells, and that Nrdp1 (show RNF41 ELISA Kits) acts as a negative regulator of PCP (show PRCP ELISA Kits) signaling by inhibiting Dvl (show DVL2 ELISA Kits) through a novel polyubiquitination mechanism.
The DEP (show ZDHHC21 ELISA Kits) domain of Dishevelled (show DVL2 ELISA Kits) undergoes a conformational switch, from monomeric to swapped dimer, to trigger DIX domain-dependent polymerization and signaling to beta-catenin (show CTNNB1 ELISA Kits).
two mutually exclusive functions of the DEP (show ZDHHC21 ELISA Kits) domain in Wnt (show WNT2 ELISA Kits) signal transduction - binding to Frizzled to recruit Dishevelled (show DVL2 ELISA Kits) to the receptor complex, is reported.
we show that Wnt5a (show WNT5A ELISA Kits) rapidly represses rDNA gene transcription in breast cancer cells and generates a chromatin state with reduced transcription of rDNA by RNA polymerase I (show POLR1C ELISA Kits) (Pol I). These effects were specifically dependent on Dishevelled1 (DVL1), which accumulates in nucleolar organizer regions (NORs) and binds to rDNA regions of the chromosome.
Data show that dishevelled (show DVL2 ELISA Kits) proteins DVL1, 2 and 3 were exclusively expressed in chronic lymphatic leukaemia (CLL) cells as compared to normal peripheral blood mononuclear cells (PBMCs).
The secreted frizzled-related protein (show SFRP2 ELISA Kits) and disheveled protein family members appear to be actively involved in the pathogenesis of primary testicular germ cell tumors.
Data show that receptor for activated C kinase 1 (RACK1 (show GNB2L1 ELISA Kits)) interacts with Dishevelled (Dvl (show DVL2 ELISA Kits)) proteins and promotes their lysosomal degradation, and this effect is enhanced by autophagy induction.
TMEM88 stimulated triple negative breast cancer cell invasion by interacting with DVLl.
Data show that the peptide binding pocket of the Dishevelled 1 (Dvl1) PDZ domain (show INADL ELISA Kits) is stabilized upon CXXC finger 5 protein (CXXC5 (show CXXC5 ELISA Kits)) binding.
Here we show that the peptide-binding pocket of the Dvl PDZ domain (show INADL ELISA Kits) can be occupied by Dvl's own highly conserved C-terminus, inducing a closed conformation.
The interaction of Dvl1 with Syt-1 (show SYT1 ELISA Kits), which is regulated by Wnts, modulates neurotransmitter release.
findings indicate that Dvl-1 may be an underlying participant of oxidative stress induced (show SQSTM1 ELISA Kits) by selenium deficiency
These results support a novel cell-autonomous postsynaptic role for Dact1 (show DACT1 ELISA Kits), in cooperation with Dishevelled-1 and possibly Disrupted in Schizophrenia-1 (show DISC1 ELISA Kits), in the formation of synapses on cortical interneuron dendrites.
we show that Dvl-1 expression is restricted to OSNs in the dorsal recess of the nasal cavity, and labels a unique subpopulation of glomeruli. Dvl-2 (show DVL2 ELISA Kits) and Dvl-3 (show DVL3 ELISA Kits) have a widespread distribution in both the olfactory epithelium and olfactory bulb .
Fuzzy appears to control subcellular localization of the core PCP (show BMP1 ELISA Kits) protein Dishevelled (show DVL2 ELISA Kits), recruiting it to Rab8 (show RAB8A ELISA Kits)-positive vesicles and to the basal body and cilium. We show that loss of Fuzzy results in inhibition of PCP (show BMP1 ELISA Kits) signaling
A Wnt5a (show WNT5A ELISA Kits)--> Dvl PCP (show BMP1 ELISA Kits) signaling cascade may regulate actin polymerization and protrusive cell behavior in the caudal (show CAD ELISA Kits) splanchnic mesoderm to promote second heart field deployment, outflow tract lengthening and cardiac looping.
Findings indicate that Daple (show CCDC88C ELISA Kits) interacts with Dishevelled (show DVL2 ELISA Kits) to direct the Dishevelled (show DVL2 ELISA Kits)/protein kinase (show CDK7 ELISA Kits) lambda protein complex to activate Rac (show AKT1 ELISA Kits), which in turn mediates the non-canonical Wnt (show WNT2 ELISA Kits) signalling pathway required for cell migration.
The antagonistic functions of Vangl2 (show VANGL2 ELISA Kits) and Dvl1 allow sharpening of planar cell polarity signaling locally on the tips of the filopodia to sense directional cues, Wnts, eventually causing turning of growth cones.
Different Dvl (show DVL2 ELISA Kits) proteins (Dvl1, Dvl2 (show DVL2 ELISA Kits), Dvl3 (show DVL3 ELISA Kits)) and the composition of dishevelled (show DVL2 ELISA Kits)-beta-arrestin protein complexes contribute to the specific activation of individual branches of Wnt (show WNT2 ELISA Kits) signaling in Xenopus gastrulation.
DVL1, the human homolog of the Drosophila dishevelled gene (dsh) encodes a cytoplasmic phosphoprotein that regulates cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and neuroblast specification. DVL1 is a candidate gene for neuroblastomatous transformation. The Schwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development.
DSH homolog 1
, dishevelled 1 (homologous to Drosophila dsh)
, dishevelled, dsh homolog 1
, segment polarity protein dishevelled homolog DVL-1
, dishevelled 1
, dishevelled, dsh homolog 2, like