Browse our GPBAR1 (GPBAR1) ELISA Kits

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G Protein-Coupled Bile Acid Receptor 1 ELISA Kits (GPBAR1)
On www.antibodies-online.com are 6 G Protein-Coupled Bile Acid Receptor 1 (GPBAR1) ELISA Kits from 3 different suppliers available. Additionally we are shipping GPBAR1 Antibodies (109) and GPBAR1 Proteins (3) and many more products for this protein. A total of 124 GPBAR1 products are currently listed.
Synonyms:
BG37, CD344, EVR1, FEVR, Fz-4, Fz4, FZD4S, FzE4, Gpbar1, GPCR, GPCR19, GPR131, hFz4, M-BAR, MGC84403, Tgr5
list all ELISA KIts Gene Name GeneID UniProt
GPBAR1 8322 Q9ULV1
GPBAR1 227289 Q80SS6
GPBAR1 338443 Q80T02

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More ELISA Kits for GPBAR1 Interaction Partners

Human G Protein-Coupled Bile Acid Receptor 1 (GPBAR1) interaction partners

  1. FZD4 (show FZD4 ELISA Kits) down-regulation leads to loss of WNT (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signal activity and subsequently to reduced alveolar epithelial cell wound repair capacity and impaired expression of elastogenic components.

  2. his study showed that Let7b modulates the proliferation, invasiveness, and migration of liver cancer cell and reduces the proportion of cancer stem cells in liver cancer cell by inhibiting Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling pathway via downregulated Frizzled4 (show FZD4 ELISA Kits).

  3. Among the detected mutations, LRP5 (show LRP5 ELISA Kits) accounted for the largest proportion with a mean mutation rate of 16.1% (5/31, 16.1%), followed by NDP (show NDP ELISA Kits) (3/31, 9.7%), FZD4 (show FZD4 ELISA Kits) (2/31, 6.5%), TSPAN12 (show TSPAN12 ELISA Kits) (1/31, 3.2%), and KIF11 (show KIF11 ELISA Kits) (1/31, 3.2%). All the novel changes were predicted to be pathogenic by a series of bioinformatics analyses.

  4. bile acids promote intestinal epithelial cell proliferation and decrease mucosal injury by upregulating TGR5 expression in obstructive jaundice.

  5. The generated contour maps revealed the important structural insights for the activity of the compounds. The results obtained from this study could be helpful in the development of novel and more potent agonists of TGR5.

  6. human FZD4 assembles-in a DVL-independent manner-with Galpha12/13 but not representatives of other heterotrimeric G protein subfamilies.

  7. TGR5 functions as a tumor-suppressor in patients with ampullary adenocarcinoma and preoperative hyperbilirubinemia

  8. We conclude that Claudin-2 (show CLDN2 ELISA Kits) expression is significantly associated with bile acid receptors VDR (show CYP27B1 ELISA Kits) and TGR5 expression. Our studies identify a novel role of a tight junction protein (show OCLN ELISA Kits) in the development and progression of esophageal mucosal metaplasia, dysplasia and carcinoma.

  9. Several novel mutations (missense, non-stop (show USP22 ELISA Kits) and insertion) were detected in the coding regions of FZD4 (show FZD4 ELISA Kits), TSPAN12 (show TSPAN12 ELISA Kits) and ZNF408 genes among the unrelated familial exudative vitreoretinopathy probands. The mutations in FZD4 (show FZD4 ELISA Kits) and TSPAN12 (show TSPAN12 ELISA Kits) were involved in autosomal dominant and autosomal recessive families and further validates the involvement of these gene in exudative vitreoretinopathy development.

  10. this is the first report of bile acid derivatives able to antagonize GPBAR1 and and farnesoid X receptor (FXR (show NR1H4 ELISA Kits)) modulatory activity.

Mouse (Murine) G Protein-Coupled Bile Acid Receptor 1 (GPBAR1) interaction partners

  1. Data suggest that FXR (show NR1H4 ELISA Kits) and TGR5 expression is down-regulated in aging kidney; caloric restriction prevents these age-related changes. Additionally, in long-lived Ames dwarf (show PROP1 ELISA Kits) mice, renal FXR (show NR1H4 ELISA Kits) and TGR5 expression is up-regulated. Treatment of aged mice with dual FXR (show NR1H4 ELISA Kits)/TGR5 agonist reverses age-related changes in kidney structure/function. (FXR (show NR1H4 ELISA Kits) = farnesoid X activated receptor (show NR1H4 ELISA Kits); TGR5 = G protein-coupled bile acid receptor 1)

  2. GPBAR1/TGR5 receptor agonist, tauroursodeoxycholic acid, has anti-inflammatory effects in microglial cells.

  3. Vertical sleeve gastrectomy achieves its postoperative therapeutic effects through enhanced TGR5 signaling.

  4. These results suggest that TGR5 contributes to the glucoregulatory benefits of vertical sleeve gastrectomy surgery by promoting metabolically favourable shifts in the circulating bile acid pool.

  5. findings uncovered a novel mechanism in which INT-767 activation of FXR (show NR1H4 ELISA Kits) induces Tgr5 gene expression and increases Ca(2 (show CA2 ELISA Kits)+) levels and cAMP activity to stimulate GLP-1 (show GCG ELISA Kits) secretion and improve hepatic glucose and lipid metabolism in high-fat diet-induced obese mice.

  6. The results suggest that TGR5 activation mediates cross-talk between alpha- and beta-cells by switching from glucagon (show GCG ELISA Kits) to GLP-1 (show GCG ELISA Kits) to restore beta- cell mass and function under hyperglycemic conditions.

  7. TGR5 is an important mediator of bile acid-induced cholangiocyte proliferation in vivo and in vitro. Furthermore, TGR5 protects cholangiocytes from death receptor-mediated apoptosis.

  8. miR (show MLXIP ELISA Kits)-26a is a target gene of bile acid receptor (show NR1H4 ELISA Kits) GPBAR-1/TGR5

  9. Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling

  10. Data show that the action of bile acids on -like peptide-1 (GLP-1 (show GCG ELISA Kits)) secretion is predominantly mediated by G protein-coupled bile acid receptor (show NR1H4 ELISA Kits) GPBAR1 (TGR5) located on the basolateral L-cell membrane.

Cow (Bovine) G Protein-Coupled Bile Acid Receptor 1 (GPBAR1) interaction partners

  1. TGR5 agonism induces NO production via Akt (show AKT1 ELISA Kits) activation and intracellular Ca(2 (show CA2 ELISA Kits)+) increase in vascular endothelial cells, and this function inhibits monocyte adhesion in response to inflammatory stimuli.

Rabbit G Protein-Coupled Bile Acid Receptor 1 (GPBAR1) interaction partners

  1. TGR5 has been linked to signaling pathways involved in metabolism, cell survival, proliferation and apoptosis, which suggest a possible role of TGR5 in cancer development.

GPBAR1 Antigen Profile

Antigen Summary

This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein.

Alternative names and synonyms associated with GPBAR1

  • G protein-coupled bile acid receptor 1 (gpbar1) Elisa Kit
  • G protein-coupled bile acid receptor 1 (GPBAR1) Elisa Kit
  • frizzled family receptor 4 (FZD4) Elisa Kit
  • G protein-coupled bile acid receptor 1 (Gpbar1) Elisa Kit
  • G protein-coupled receptor (TGR5) Elisa Kit
  • BG37 Elisa Kit
  • CD344 Elisa Kit
  • EVR1 Elisa Kit
  • FEVR Elisa Kit
  • Fz-4 Elisa Kit
  • Fz4 Elisa Kit
  • FZD4S Elisa Kit
  • FzE4 Elisa Kit
  • Gpbar1 Elisa Kit
  • GPCR Elisa Kit
  • GPCR19 Elisa Kit
  • GPR131 Elisa Kit
  • hFz4 Elisa Kit
  • M-BAR Elisa Kit
  • MGC84403 Elisa Kit
  • Tgr5 Elisa Kit

Protein level used designations for GPBAR1

G protein-coupled bile acid receptor 1 , G-protein coupled bile acid receptor BG37 , WNT receptor frizzled-4 , frizzled 4, seven transmembrane spanning receptor , frizzled homolog 4 , frizzled-4 , G-protein coupled bile acid receptor 1 , G-protein coupled receptor GPCR19 , hBG37 , hGPCR19 , membrane bile acid receptor , membrane-type receptor for bile acids , G protein-coupled receptor TGR5 , G protein-coupled receptor , M-BAR

GENE ID SPECIES
447779 Xenopus laevis
488521 Canis lupus familiaris
697937 Macaca mulatta
741111 Pan troglodytes
8322 Homo sapiens
151306 Homo sapiens
227289 Mus musculus
338443 Rattus norvegicus
317756 Bos taurus
100009346 Oryctolagus cuniculus
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