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The mRNA expression levels of DKK-1 (show DKK1 ELISA Kits) binding receptor LRP5 (show LRP5 ELISA Kits)/6 and Krm1 (show KREMEN1 ELISA Kits)/2 in SCs (show TWIST1 ELISA Kits) from patients with MM were significantly higher than those in myeloma cells and in SCs (show TWIST1 ELISA Kits) from healthy donors.
The dysregulated collagen metabolic process, ECM (show MMRN1 ELISA Kits)-receptor interaction and p53 (show TP53 ELISA Kits) signaling pathway may be responsible for impaired fracture healing of osteoporotic Krm2 transgenic mice.
Bone formation was more reduced in Col1a1 (show COL1A1 ELISA Kits)-Krm2 than in Lrp5 (show LRP5 ELISA Kits)-/- mice, whereas osteoclast number was similarly increased in both genotypes in comparison with wild-type mice
effects of Krm2 on bone remodeling
Kremen (show KREMEN1 ELISA Kits) proteins are Dickkopf (show DKK1 ELISA Kits) receptors that regulate Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signalling.
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.
kringle containing transmembrane protein 2
, kremen 2
, kringle-containing transmembrane protein 2
, kremen protein 2-like
, dickkopf receptor 2
, kremen protein 2
, kringle domain-containing transmembrane protein 2
, kringle-containing protein marking the eye and the nose