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anti-Human PLCB3 Antibodies:
anti-Rat (Rattus) PLCB3 Antibodies:
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Data suggest that 300-residue C-terminal domain of PLCB3 promotes adsorption to phospholipid monolayer/membrane bilayer and is required for spatial organization/adsorption of PLCB3 on membrane surface; defects in phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis alter monolayer adsorption, thus, suggesting role of active site in this process; PLCB3 is preferentially adsorbed to region of bilayer enriched with PIP2.
These results indicate that the mechanism by which Galphaq (show GNAQ Antibodies) and PLC (show HSPG2 Antibodies)-beta3 mutually regulate each other is far more complex than a simple, two-state allosteric model and instead is probably kinetically determined.
We propose that unliganded PLC (show HSPG2 Antibodies)-beta exists in equilibrium between a closed conformation observed in crystal structures and an open conformation where the PH domain moves away from the EF hands. Therefore, intrinsic movement of the PH domain in PLC (show HSPG2 Antibodies)-beta modulates Gbetagamma access to its binding site.
the MCP1 (show CCL2 Antibodies)-induced cortactin (show CTTN Antibodies) phosphorylation is dependent on PLCb3-mediated PKC (show PRRT2 Antibodies) activation, and siRNA-mediated down-regulation of either of these molecules prevents cortactin (show CTTN Antibodies) interaction with WAVE2 (show WASF2 Antibodies)
Gnb isoforms control a signaling pathway comprising Rac1, Plcbeta2, and Plcbeta3 leading to LFA-1 (show ITGAL Antibodies) activation and neutrophil arrest in vivo
membranes are integral for the activation of PLC (show HSPG2 Antibodies)-beta isozymes by diverse modulators.
the M3 muscarinic receptor (show CHRM3 Antibodies) maximizes the efficiency of PLCbeta3 signaling beyond its canonical role as a guanine nucleotide exchange factor (show RASGRF1 Antibodies) for Galpha (show SUCLG1 Antibodies).
This study provides an understanding of the structural basis for the PDZ (show INADL Antibodies)-mediated NHERF1 (show SLC9A3R1 Antibodies)-PLCbeta3 interaction that could prove valuable in selective drug design against CXCR2 (show CXCR2 Antibodies)-related cancers.
PLCbeta3 is enriched in the cytosol.
phospholipase C (show PLC Antibodies)-beta3 structure reveals the role of the its distal C-terminal domain
Schmerle (she) encodes a zebrafish ortholog of Phospholipase C, beta 3 (Plcbeta3) which is required in cranial neural crest cells for Edn1 regulation of pharyngeal arch patterning.
investigation of physiological involvement of PLCbeta3 signaling in ovulatory-size follicles: identification of PLCbeta3 as a mediator of LH-induced differentiation responses of granulosa cells; up-regulation of PLCbeta3 during oogenesis/ovulation
Data, including data from studies using transgenic/knockout mice, suggest that Ppp1ca (show PPP1CA Antibodies) and Gnb1 (show GNB1 Antibodies) interact in quiescent platelets; then, Ppp1ca (show PPP1CA Antibodies) and Plcb3 interact during platelet aggregation; thus, Gnb1 (show GNB1 Antibodies) enlists Ppp1ca (show PPP1CA Antibodies) to modulate G protein-coupled receptor (show GPR34 Antibodies) signaling. (Ppp1ca (show PPP1CA Antibodies) = protein phosphatase 1 (show PPP1CB Antibodies), catalytic subunit alpha; Gnb1 (show GNB1 Antibodies) = guanine nucleotide-binding protein (show TRIM23 Antibodies), subunit beta-1; Plcb3 = phospholipase C (show PLC Antibodies), subunit beta-3)
Plcb3-deficient mice spontaneously develop atopic dermatitis-like skin lesions.
Data suggest that PLCbeta3 acts as a negative regulator of VEGF- (vascular endothelial growth factor A (show VEGFA Antibodies)-) mediated vascular hyperpermeability through intracellular calcium signaling.
GPCR (show GPBAR1 Antibodies) activation of Ras and PI3Kc in neutrophils depends on PLCb2 (show PLCb2 Antibodies)/b3 and the RasGEF RasGRP4 (show RASGRP4 Antibodies).
defined a PLC-beta3- and SHP-1-mediated signaling pathway for FcvarepsilonRI-mediated cytokine production
Cellular G(i)-G(q) synergism derives from direct supra-additive stimulation of phospholipase C (show PLC Antibodies)-beta3 by G protein subunits Gbetagamma and Galpha(q (show GNAQ Antibodies)).
Expression of Plcb3 was studied in a cell line during myoblast differentiation.
both PLCbeta2/beta3 and PI3Kgamma (show PIK3CG Antibodies) play vital roles in platelet cytoskeletal dynamics
results suggest that activation of PLC (show HSPG2 Antibodies)-b3 by pertussis toxin-sensitive G proteins is responsible for transient [Ca2 (show CA2 Antibodies)+]i increase in response to thrombin (show F2 Antibodies)
This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
, PLC beta 3
, phosphoinositide phospholipase C-beta-3
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3
, phospholipase C beta 3
, phospholipase C-beta-3
, phospholipase C, beta 3 (phosphatidylinositol-specific)
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3-like