Secreted frizzled-related protein 1 (sFRP-1) functions as a modulator of Wnt signaling through direct interaction with Wnts. sFRP-1 has a role in regulating cell growth and differentiation in specific cell types. sFRP-1 decreases intracellular beta-catenin levels. sFRP-1 is down-regulated in colorectal and breast tumors, and up-regulated in uterine leiomyomas under high estrogenic conditions.
Each vial contains 0.1 mg IgG in 0.1 mL of PBS pH7.4 with 0.09% sodium azide.
Precaution of Use
Warning: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.