anti-ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 (AGAP2) Antibodies

Human ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 (AGAP2) interaction partners

1. A pleckstrin homology domain in PIKE-L directly binds alpha-synuclein and antagonizes its aggregation. Accordingly, PIKE-L overexpression decreases dopaminergic cell death elicited by MPP(+), whereas PIKE-L knockdown elevates alpha-synuclein oligomerization and cell death.

2. these findings support that PIKE amplification or overexpression coordinately acts with CDK4 (show CDK4 Antibodies) to drive glioblastoma tumorigenesis.

3. Studies showed that overexpression or mutation of PIKE has been observed in a variety of tumors, promoting cancer cell growth, transformation and invasion through AKT signaling or other signaling pathways, such as focal adhesion kinase. [review]

4. Mutation of Fyn (show FYN Antibodies) phosphorylation sites on PIKE-A, depletion of Fyn (show FYN Antibodies), or pharmacological inhibition of Fyn (show FYN Antibodies) blunts the association between PIKE-A and AMPK (show PRKAA1 Antibodies), resulting in loss of its inhibitory effect on AMPK (show PRKAA1 Antibodies).

5. expression of PLC-gamma1 (show PLCG1 Antibodies) and PIKE positively correlated with the tumor differentiation of oral squamous cell carcinoma.

6. PIKE reduction rescued PI3K (show PIK3CA Antibodies)-dependent and -independent neuronal defects in fragile X (show FMR1 Antibodies) syndrome.

7. In this review the CENTG1 gene is amplified in a variety of human cancers which lead to the enhancement of tumor invasion.

8. AGAP2 plays a role in the signalling and recycling of beta2-adrenergic receptors.

9. Fyn (show FYN Antibodies) regulates the activity of the adipogenic transcription factor signal transducer and activator of transcription 5a (STAT5a (show STAT5A Antibodies)) through enhancing its interaction with the GTPase (show RACGAP1 Antibodies) phosphoinositide 3-kinase enhancer A (PIKE-A).

10. PIKE is highly expressed in human squamous cell carcinoma and has a critical role in EGF (show EGF Antibodies)-induced squamous cell carcinoma proliferation.

Mouse (Murine) ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 (AGAP2) interaction partners

1. Dopamine and DOPAC were not changed in 3-mo-old mice but were decreased at 8 mo in the striatum of PIKE-KO mice compared with wild-type mice. DA and DOPAC in hippocampus and substantia nigra were significantly decreased in 3-mo-old and 8-mo-old PIKE-KO mice as compared with wild-type mice. More severe motor defects in PIKE-KO and Fyn (show FYN Antibodies)-KO mice than in wild-type mice exposed to alpha synuclein and MPTP (show PTPN2 Antibodies).

2. Depletion of PIKE-A in C2C12 myotubes diminished the inhibitory activities of TNF-alpha (show TNF Antibodies) on mitochondrial respiration and lipid oxidation, whereas PIKE-A overexpression exacerbated these cellular responses.

3. PIKE plays pivotal roles to advance oligodendroglia development and myelinogenesis through Akt (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) activation.

4. Results demonstrate that the integrity of PIKE signaling is essential for protecting the neurons from excitotoxicity-stimulated damage both in vitro and in vivo.

5. Fyn (show FYN Antibodies) regulates the activity of the adipogenic transcription factor signal transducer and activator of transcription 5a (STAT5a (show STAT5A Antibodies)) through enhancing its interaction with the GTPase (show RACGAP1 Antibodies) phosphoinositide 3-kinase enhancer A (PIKE-A).

6. PIKE is a critical factor in controlling synaptic AMPA (show GRIA3 Antibodies) receptor insertion.

7. data established the critical role of PIKE in regulating neuronal survival and development by substantiating the PI3K/Akt (show AKT1 Antibodies) pathway.

8. PIKE-A is required for prolactin (show PRL Antibodies)-mediated STAT5a (show STAT5A Antibodies) activation in mammary gland development.

9. PIKE knockout mice show augmented lipid oxidation, which is accompanied by enhanced AMPK (show PRKAA1 Antibodies) phosphorylation in muscle and adipose tissue and is implicated in obesity and diabetes development.

10. PIKE-L acts as a downstream survival effector for netrin-1 (show NTN1 Antibodies) through UNC5B (show UNC5B Antibodies) in the nervous system