anti-ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 (AGAP2) Antibodies

The protein encoded by AGAP2 belongs to the centaurin gamma-like family. Additionally we are shipping ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 Proteins (3) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
AGAP2 116986 Q99490
AGAP2 216439 Q3UHD9
AGAP2 65218 Q8CGU4
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Top anti-ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 Antibodies at antibodies-online.com

Showing 10 out of 105 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-CENTG1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: THP-1 cell lysate 100 μL 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, IHC, WB ABIN570975 (0.3µg/ml) staining of Human Amygdala lysate (35µg protein in RIPA buffer). Detected by chemiluminescence. 100 μg 6 to 7 Days
$429.84
Details
Human Rabbit Un-conjugated EIA, WB CENTG1 Antibody (C-term) western blot analysis in mouse brain tissue lysates (35µg/lane).This demonstrates the CENTG1 antibody detected the CENTG1 protein (arrow). 0.4 mL 6 to 8 Days
$484.00
Details
Human Goat Un-conjugated ELISA, IHC, IHC (p), WB Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated EIA, WB   0.1 mg 4 to 8 Days
$632.50
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, IHC (p), WB Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with AGAP2 antibody ABIN214332 at 2.5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-AGAP2 / PIKE antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg 11 to 14 Days
$550.00
Details
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
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Human Rabbit Un-conjugated IHC, ELISA, WB   100 μg 15 to 19 Days
$527.03
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Human Heart (formalin-fixed, paraffin-embedded) stained with AGAP2 antibody ABIN213912 at 20 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-AGAP2 / PIKE antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. 0.05 mg 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB   0.1 mg 4 to 8 Days
$522.50
Details

Top referenced anti-ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 Antibodies

  1. Human Polyclonal AGAP2 Primary Antibody for IHC (p), WB - ABIN541229 : Jackson, Kearns, Theibert: Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling. in Trends in biochemical sciences 2000 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal AGAP2 Primary Antibody for IHC, ELISA - ABIN1002996 : Rong, Ahn, Huang, Nagata, Kalman, Kapp, Tu, Worley, Snyder, Ye: PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. in Nature neuroscience 2003 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal AGAP2 Primary Antibody for ELISA, WB - ABIN542451 : Liu, Jang, Liu, Cheng, Peng, Yepes, Li, Matthews, Watts, Asano, Hara-Nishimura, Luo, Ye: Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase. in Molecular cell 2008 (PubMed)

More Antibodies against ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 Interaction Partners

Human ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 (AGAP2) interaction partners

  1. The role of AGAP2 in the pro-fibrogenic phenotype of hepatic stellate cells in response to TGFbeta.

  2. A pleckstrin homology domain in PIKE-L directly binds alpha-synuclein and antagonizes its aggregation. Accordingly, PIKE-L overexpression decreases dopaminergic cell death elicited by MPP(+), whereas PIKE-L knockdown elevates alpha-synuclein oligomerization and cell death.

  3. these findings support that PIKE amplification or overexpression coordinately acts with CDK4 to drive glioblastoma tumorigenesis.

  4. Studies showed that overexpression or mutation of PIKE has been observed in a variety of tumors, promoting cancer cell growth, transformation and invasion through AKT signaling or other signaling pathways, such as focal adhesion kinase. [review]

  5. Mutation of Fyn phosphorylation sites on PIKE-A, depletion of Fyn, or pharmacological inhibition of Fyn blunts the association between PIKE-A and AMPK, resulting in loss of its inhibitory effect on AMPK.

  6. expression of PLC-gamma1 and PIKE positively correlated with the tumor differentiation of oral squamous cell carcinoma.

  7. PIKE reduction rescued PI3K-dependent and -independent neuronal defects in fragile X syndrome.

  8. In this review the CENTG1 gene is amplified in a variety of human cancers which lead to the enhancement of tumor invasion.

  9. AGAP2 plays a role in the signalling and recycling of beta2-adrenergic receptors.

  10. Fyn regulates the activity of the adipogenic transcription factor signal transducer and activator of transcription 5a (STAT5a) through enhancing its interaction with the GTPase phosphoinositide 3-kinase enhancer A (PIKE-A).

  11. PIKE is highly expressed in human squamous cell carcinoma and has a critical role in EGF-induced squamous cell carcinoma proliferation.

  12. The presence of heterogeneous missense mutations of GGAP2 in prostate cancer was associated with aggressive clinical behavior.

  13. PIKE is a critical factor in controlling synaptic AMPA receptor insertion.

  14. Akt-phosphorylated PIKE-A inhibits UNC5B-induced apoptosis in cancer cell lines in a p53-dependent manner. [PIKE-A]

  15. regulates retrograde protein transport between early endosomes and the Golgi complex

  16. This study have identified, cloned and characterized PIKE-L, which localizes to both the cytoplasm and the nucleus, activates mGlur1 enhances formation of an mGluRI-Homer-PIKE-L complex, then activates PI3 kinase activity and prevents neuronal apoptosis.

  17. a physiologic regulator of Akt and an oncogenic effector of cell invasion

  18. PIKE binds PI 3-kinase & stimulates its lipid kinase activity. There are 3 isoforms which function throught the cell and meadiate processes from invasiveness to apoptosis. Review.

  19. The AGAP2 colocalized with AP-1, transferrin receptor and Rab4 on endosomes. Overexpression of AGAP2 changed the intracellular distribution of AP-1 and promoted Rab4-dependent fast recycling of transferrin.

  20. an important role of PIKE gene aberrations in the molecular pathogenesis of primary glioblastomas

Mouse (Murine) ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 (AGAP2) interaction partners

  1. Dopamine and DOPAC were not changed in 3-mo-old mice but were decreased at 8 mo in the striatum of PIKE-KO mice compared with wild-type mice. DA and DOPAC in hippocampus and substantia nigra were significantly decreased in 3-mo-old and 8-mo-old PIKE-KO mice as compared with wild-type mice. More severe motor defects in PIKE-KO and Fyn-KO mice than in wild-type mice exposed to alpha synuclein and MPTP.

  2. Depletion of PIKE-A in C2C12 myotubes diminished the inhibitory activities of TNF-alpha on mitochondrial respiration and lipid oxidation, whereas PIKE-A overexpression exacerbated these cellular responses.

  3. PIKE plays pivotal roles to advance oligodendroglia development and myelinogenesis through Akt/mTOR activation.

  4. Results demonstrate that the integrity of PIKE signaling is essential for protecting the neurons from excitotoxicity-stimulated damage both in vitro and in vivo.

  5. Fyn regulates the activity of the adipogenic transcription factor signal transducer and activator of transcription 5a (STAT5a) through enhancing its interaction with the GTPase phosphoinositide 3-kinase enhancer A (PIKE-A).

  6. PIKE is a critical factor in controlling synaptic AMPA receptor insertion.

  7. data established the critical role of PIKE in regulating neuronal survival and development by substantiating the PI3K/Akt pathway.

  8. PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development.

  9. PIKE knockout mice show augmented lipid oxidation, which is accompanied by enhanced AMPK phosphorylation in muscle and adipose tissue and is implicated in obesity and diabetes development.

  10. PIKE-L acts as a downstream survival effector for netrin-1 through UNC5B in the nervous system

ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 (AGAP2) Antigen Profile

Protein Summary

The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with AGAP2

  • ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 (AGAP2) antibody
  • ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 (agap2) antibody
  • ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 (Agap2) antibody
  • Centg1 antibody
  • GGAP2 antibody
  • mKIAA0167 antibody
  • Pike antibody
  • zgc:153779 antibody

Protein level used designations for AGAP2

arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 , Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 2 , GTP-binding and GTPase activating protein 2 , centaurin, gamma 1 , cnt-g1 , phosphatidylinositol 3-kinase enhancer , phosphatidylinositol-3-kinase enhancer , phosphoinositide 3-kinase enhancer , AGAP-2 , PIKE , centaurin-gamma-1 , nuclear GTPase PIKE

GENE ID SPECIES
504833 Bos taurus
565109 Danio rerio
116986 Homo sapiens
216439 Mus musculus
65218 Rattus norvegicus
100050853 Equus caballus
481130 Canis lupus familiaris
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