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AGAP2 Products

(ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 (AGAP2))

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The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011].

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Featured AGAP2 Categories

AGAP2 Antibodies

High quality antibodies with extensive validation data.

AGAP2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended AGAP2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IHC, WB
Validations
  • (3)
Cat. No. ABIN7189712
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, WB
Validations
  • (3)
Cat. No. ABIN570975
Quantity 100 μg
Datasheet Datasheet
Reactivity Horse, Human, Monkey, Mouse, Rat
Application IHC, IHC (p), WB
Validations
  • (2)
Cat. No. ABIN960074
Quantity 100 μg
Datasheet Datasheet

Recommended AGAP2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6223198
Quantity 96 tests
Datasheet Datasheet

Recommended AGAP2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3135049
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3088375
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1344548
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our AGAP2 products

Liu, Jang, Liu, Cheng, Peng, Yepes, Li, Matthews, Watts, Asano, Hara-Nishimura, Luo, Ye: "Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase." in: Molecular cell, Vol. 29, Issue 6, pp. 665-78, (2008) (PubMed).

Ahn, Rong, Kroll, Van Meir, Snyder, Ye: "PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion." in: The Journal of biological chemistry, Vol. 279, Issue 16, pp. 16441-51, (2004) (PubMed).

Hatziioannou, Perez-Caballero, Yang, Cowan, Bieniasz: "Retrovirus resistance factors Ref1 and Lv1 are species-specific variants of TRIM5alpha." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 29, pp. 10774-9, (2004) (PubMed).

Stremlau, Owens, Perron, Kiessling, Autissier, Sodroski: "The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys." in: Nature, Vol. 427, Issue 6977, pp. 848-53, (2004) (PubMed).

Xu, Yang, Moitra, Hashimoto, Rallabhandi, Kaul, Meroni, Jensen, Weissman, DArpa: "BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta." in: Experimental cell research, Vol. 288, Issue 1, pp. 84-93, (2003) (PubMed).

Rong, Ahn, Huang, Nagata, Kalman, Kapp, Tu, Worley, Snyder, Ye: "PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis." in: Nature neuroscience, Vol. 6, Issue 11, pp. 1153-61, (2003) (PubMed).

Ye, Hurt, Wu, Fang, Luo, Hong, Blackshaw, Ferris, Snyder: "Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N." in: Cell, Vol. 103, Issue 6, pp. 919-30, (2001) (PubMed).

Jackson, Kearns, Theibert: "Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling." in: Trends in biochemical sciences, Vol. 25, Issue 10, pp. 489-95, (2000) (PubMed).

Synonyms and alternative names related to AGAP2

ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 (AGAP2), ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 (agap2), ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 (Agap2), CENTG1, Centg1, GGAP2, mKIAA0167, PIKE, Pike, zgc:153779

Protein level used designations for AGAP2

  • arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
  • Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 2
  • GTP-binding and GTPase activating protein 2
  • centaurin, gamma 1
  • cnt-g1
  • phosphatidylinositol 3-kinase enhancer
  • phosphatidylinositol-3-kinase enhancer
  • phosphoinositide 3-kinase enhancer
  • AGAP-2
  • PIKE
  • centaurin-gamma-1
  • nuclear GTPase PIKE
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