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Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Additionally we are shipping and PD-L1 Proteins (104) and many more products for this protein.
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Human PD-L1 ELISA Kit for Sandwich ELISA - ABIN417524
Curry, Lawrence, Burden: Ovarian sympathectomy in the golden hamster: effects on estrous cyclicity and follicular development. in Experimental and clinical endocrinology 1986
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Human PD-L1 ELISA Kit for Sandwich ELISA - ABIN577883
Atesoglu, Tarkun, Demirsoy, Geduk, Mehtap, Batman, Kaya, Cekmen, Gulbas, Hacıhanefioglu: Soluble Programmed Death 1 (PD-1) Is Decreased in Patients With Immune Thrombocytopenia (ITP): Potential Involvement of PD-1 Pathway in ITP Immunopathogenesis. in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 2014
Human PD-L1 ELISA Kit for Sandwich ELISA - ABIN579638
Baral, Ye, Jiang, Yao, Mao: B7-H3 and B7-H1 expression in cerebral spinal fluid and tumor tissue correlates with the malignancy grade of glioma patients. in Oncology letters 2014
We conclude that a subgroup of advanced disease ovarian cancer patients with high grade tumors, expressing PD-L1, may be prime candidates for immunotherapy targeting PD-1 (show PDCD1 ELISA Kits) signaling
PD-L1 expression is a prognostic factor related with poor survival among patients that developed non-small cell lung cancer.
The inhibition of PTEN also reduced the cancer effects of CD4+ T cells on non-small cell lung cancer (NSCLC) cell lines following miR-142-5p downregulation. Therefore, our study demonstrated that miR-142-5p regulated CD4+ T cells in human NSCLC through PD-L1 expression via the PTEN pathway.
Thus, PD-L1 mRNA expression in EGFR (show EGFR ELISA Kits)-mutant lung adenocarcinoma was associated with BIM (show BCL2L11 ELISA Kits) and VEGFA (show VEGFA ELISA Kits) mRNA expression and with shorter PFS after gefitinib therapy.
The expression of PD-L1 in breast-invasive ductal carcinoma was significantly increased, and it was related to histological grading, clinical staging, and lymph node metastasis of breast cancer.
Neither IL-17 (show IL17A ELISA Kits) nor IL-22 (show IL22 ELISA Kits), cytokines essential in the immunopathogenesis of psoriasis, alters PD-L1 expression in HaCaT cells.
PD-L1 expression and RAS status may be the prognostic indicators for metastatic Colorectal Cancer patients with palliative operation.
PD-L1 mRNA can be detected and quantitated in circulating tumor RNA of cancer patients.
expression of PD-L1 by lymphoma cells and tumor-associated macrophages mediate the trafficking of tumor-associated macrophages, which may explain the immune-escape process of tumor-associated macrophages.
Study indicated that PD-L1 expression is a negative prognostic factor in renal cell carcinoma (RCC (show XRCC1 ELISA Kits)). The results also indicate PD-L1 expression was associated more aggressive clinical features in patients with RCC (show XRCC1 ELISA Kits).
T-cell activation mediates the immunopreventive effects of anti-PD-1 (show PDCD1 ELISA Kits); PD-1 (show PDCD1 ELISA Kits) on T cells interacts with the PD-1 (show PDCD1 ELISA Kits) ligand PD-L1 on cancer cells
an enhanced expression of PD-L1 was observed besides an increased production of IFN-gamma (show IFNG ELISA Kits) by TH2 cells.
Study demonstrated that PD-L1 expression is up-regulated in the salivary glands of female NOD mice during the developmental phase of Sjgren's syndrome, which in turn hinders the development and onset of this disease in a negative feedback fashion.
PD-L1 expression on tumor cells suppressed antigen-driven TNF (show TNF ELISA Kits) production by CD8 (show CD8A ELISA Kits)(+) T cells, which could be antagonized through PD-1 (show PDCD1 ELISA Kits) blockade
B7-H1 suppresses p38 MAPK (show MAPK14 ELISA Kits) activation by sequestering DNA-PKcs (show PRKDC ELISA Kits) in order to preserve T cell survival
Anti-PD-1 (show PDCD1 ELISA Kits)/PD-L1 therapy inhibited CMT167 orthotopic lung tumors by 95%. .Silencing PD-L1 expression in CMT167 cells resulted in smaller orthotopic tumors that remained sensitive to anti-PD-L1 therapy, whereas implantation of CMT167 cells into PD-L1(-) mice blocked orthotopic tumor growth, indicating a role for PD-L1 in both the cancer cell and the microenvironment.
Combination therapies that depend on checkpoint inhibitor antibodies (Abs) such as for PD-1 (show PDCD1 ELISA Kits) or its ligand (PD-L1) together with immune stimulatory agonist Abs like anti-OX40 (show TNFRSF4 ELISA Kits) are being tested in the clinic to achieve improved antitumor effects
In estrogen receptor (show ESR1 ELISA Kits) negative breast cancer cells targeting of IL-17A (show IL17A ELISA Kits) inhibited PDL1 expression in the tumor microenvironment, decreasing the percentage of Treg cells in tumor-infiltrating lymphocytes, and promoting CD4 (show CD4 ELISA Kits)+ and CD8 (show CD8A ELISA Kits)+ T cells to secrete interferon gamma (show IFNG ELISA Kits).
Squamous cell carcinomas escape immune surveillance via inducing chronic activation and exhaustion of CD8 (show CD8A ELISA Kits)+ T Cells co-expressing PD-1 (show PDCD1 ELISA Kits) and LAG-3 (show LAG3 ELISA Kits) inhibitory receptors.
Genetic ablation of a single immune-regulatory molecule in this model [i.e., B7-homolog 1 (B7-H1, PD-L1)] not only significantly increased incidence of spontaneous CNS autoimmunity and aggravated disease course, especially in the later stages of disease, but also importantly resulted in encephalitogenic T-cell infiltration and lesion formation in normally unaffected brain regions.
This study provides novel information for the understanding of signalling through PD-L1.
These results suggest that the soluble recombinant proteins may be used to prepare monoclonal antibodies to block the PD-1 (show PDCD1 ELISA Kits)/PD-L1 pathway.
role of programmed death ligand-1 (PD-L1) during porcine circovirus type 2 (PCV2) infection and porcine circovirus associated diseases (PCVAD) development
These data suggest that overexpression of PD-L1 and PD-L2 (show PDCD1LG2 ELISA Kits) mRNA is one mechanism by which immunosupression of postweaning multisystemic wasting syndrome pigs occurs.
Retinal PLD1 expression is enhanced in radial fibers of Muller cells with age. This finding suggests that PLD1 plays an important role in signal transduction of glial cells and neuronal cells in the retina.
A porcine PD-L1 molecule was cloned using RACE (rapid amplification of cDNA ends) technology and sequenced (GenBank # AY837780); it showed high sequence homology with human PD-L1.
Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
B7 homolog 1
, CD274 antigen
, PDCD1 ligand 1
, programmed cell death 1 ligand 1
, programmed death ligand 1
, CD274 molecule
, programmed cell death ligand 1