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Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Additionally we are shipping PD-L1 Antibodies (366) and PD-L1 Proteins (83) and many more products for this protein.
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Human PD-L1 ELISA Kit for Sandwich ELISA - ABIN417524
Curry, Lawrence, Burden: Ovarian sympathectomy in the golden hamster: effects on estrous cyclicity and follicular development. in Experimental and clinical endocrinology 1986
Show all 14 Pubmed References
Human PD-L1 ELISA Kit for Sandwich ELISA - ABIN579638
Baral, Ye, Jiang, Yao, Mao: B7-H3 and B7-H1 expression in cerebral spinal fluid and tumor tissue correlates with the malignancy grade of glioma patients. in Oncology letters 2014
Human PD-L1 ELISA Kit for Sandwich ELISA - ABIN577883
Atesoglu, Tarkun, Demirsoy, Geduk, Mehtap, Batman, Kaya, Cekmen, Gulbas, Hacıhanefioglu: Soluble Programmed Death 1 (PD-1) Is Decreased in Patients With Immune Thrombocytopenia (ITP): Potential Involvement of PD-1 Pathway in ITP Immunopathogenesis. in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 2014
Genetic ablation of a single immune-regulatory molecule in this model [i.e., B7-homolog 1 (B7-H1, PD-L1)] not only significantly increased incidence of spontaneous CNS autoimmunity and aggravated disease course, especially in the later stages of disease, but also importantly resulted in encephalitogenic T-cell infiltration and lesion formation in normally unaffected brain regions.
Studied the possible role of PD-L1 on malignant melanoma initiating cells (MMICs). Found blocking of PD-L1 in melanoma cell lines impaired tumorsphere formation and induced the apoptosis. Also, blocking PD-L1 inhibited tumor growth in vivo.
B7-H1 induction in keratinocytes may play a crucial role in the protection from CD4 (show CD4 ELISA Kits)+ T cell-mediated tissue inflammation by exogenous antigens delivered from the mucosal surface in oral cavity
Interferon (show IFNA ELISA Kits)-related secretome from direct interaction between immune cells and tumor cells is required for upregulation of PD-L1 in tumor cells.
RAS signaling can upregulate tumor cell PD-L1 expression through a mechanism involving increases in PD-L1 mRNA stability via modulation of the AU-rich element-binding protein tristetraprolin (show ZFP36 ELISA Kits).
Data (including data from studies in transgenic/knockout mice) suggest that T-cell expression of Mirn155 is required to limit melanoma growth; miR (show MLXIP ELISA Kits)-155, Pdcd1 (show PDCD1 ELISA Kits), Pdcd1l1, and Ctla4 (show CTLA4 ELISA Kits) appear to regulate overlapping pathways promoting antitumor immunity. [Mirn155 = microRNA 155; Pdcd1 (show PDCD1 ELISA Kits) = programmed cell death 1 (show PDCD1 ELISA Kits) protein; Pdcd1l1 = programmed cell death 1 ligand 1 protein; Ctla4 (show CTLA4 ELISA Kits) = cytotoxic T-lymphocyte-associated protein 4 (show CTLA4 ELISA Kits)]
Expression of LAP/TGF-beta1 (show TGFB1 ELISA Kits), CD80 (show CD80 ELISA Kits), CD86 (show CD86 ELISA Kits) and PD-L1 is significantly increased in tumor-infiltrating B cells (TIL (show TLR1 ELISA Kits)-B) relative to splenic B cells. LAP/TGF-beta1 (show TGFB1 ELISA Kits) expression on TIL (show TLR1 ELISA Kits)-B progressively increased from 5.4+/-1.7% on day 8 to 43.1+/-6.1% by day 21 post tumor implantation.
spleen-derived IFN-gamma (show IFNG ELISA Kits) induces generation of PD-L1(+)-suppressive neutrophils.
PD-L1 and PD-L2 (show PDCD1LG2 ELISA Kits) in dermal fibroblasts is up-regulated by activated T cells in alopecia areata-affected skin.
It was concluded that down-regulated expression of miR (show MLXIP ELISA Kits)-143 and up-regulation of its direct target B7H1 may indicate a novel therapeutic method for radiation-induced thymic lymphoma by increased expression of miR (show MLXIP ELISA Kits)-143 or inhibition of B7H1.
interplay between donor PD-L1 and recipient PD-1 (show PDCD1 ELISA Kits) counter-regulates rejection activity against liver grafts in humans.
PD1 (show PDCD1 ELISA Kits)/PD-L1 inhibitors are overall better tolerated than chemotherapy. In addition to efficacy data from trials, our findings provide useful information for clinicians for well-balanced discussions with their patients on the risks and benefits of treatment options for advanced cancer.
PDL1 expression might refine the prediction of metastatic relapse in operated pancreatic cancer.
We investigated PD-L1 expression using the SP142 antibody and found higher expression in a subset of advanced thyroid cancers such as anaplastic thyroid carcinoma and follicular thyroid carcinoma.Identification of PD-L1 expression may have direct therapeutic relevance to patients with refractory thyroid cancer.
Taken together, a stiff substrate enhanced PD-L1 expression via actin-dependent mechanisms in lung cancer cells. It is suggested that stiffness as a tumor environment regulates PD-L1 expression, which leads to evasion of the immune system and tumor growth.
Study showed that the pattern of PD-L1 expression in tonsillar cancer is related to HPV and smoking. There was a strong interaction between HPV status and PD-L1 status with the worst outcome seen in patients with HPV-negative/PD-L1-negative cancer.
High CD274 expression is associated with response to chemotherapy in Carcinoma, Non-Small-Cell Lung.
In EBV+ GC, authors observed PD-L1 staining in tumor cells in 50% (16/32) and immune cells in 94% (30/32) of cases. Among EBV-negative GCs (show GCLC ELISA Kits), PD-L1 expression within tumors cells was observed only in cases with microsatellite instability (MSI (show MSI1 ELISA Kits)), although 35% of EBV-/MSS (show SIL1 ELISA Kits) GCs (show GCLC ELISA Kits) possessed PD-L1 expression of inflammatory cells.
Methylated PD-L1 is a promising biomarker for the risk stratification of prostate cancer patients and might offer additional relevant prognostic information to the implemented clinical parameters, particularly in the setting of immune checkpoint inhibition.
In human gastrointestinal stromal tumors (GIST) cell lines, treatment with imatinib abrogated the IFNgamma-induced upregulation of PD-L1 via STAT1 (show STAT1 ELISA Kits) inhibition. PD-1 (show PDCD1 ELISA Kits)/PD-L1 blockade is a promising strategy to improve the effects of targeted therapy in GISTs
These results suggest that the soluble recombinant proteins may be used to prepare monoclonal antibodies to block the PD-1 (show PDCD1 ELISA Kits)/PD-L1 pathway.
role of programmed death ligand-1 (PD-L1) during porcine circovirus type 2 (PCV2) infection and porcine circovirus associated diseases (PCVAD) development
These data suggest that overexpression of PD-L1 and PD-L2 (show PDCD1LG2 ELISA Kits) mRNA is one mechanism by which immunosupression of postweaning multisystemic wasting syndrome pigs occurs.
Retinal PLD1 expression is enhanced in radial fibers of Muller cells with age. This finding suggests that PLD1 plays an important role in signal transduction of glial cells and neuronal cells in the retina.
A porcine PD-L1 molecule was cloned using RACE (rapid amplification of cDNA ends) technology and sequenced (GenBank # AY837780); it showed high sequence homology with human PD-L1.
This study provides novel information for the understanding of signalling through PD-L1.
Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
, CD274 antigen
, programmed cell death 1 ligand 1
, programmed cell death ligand 1
, B7 homolog 1
, PDCD1 ligand 1
, programmed death ligand 1