Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner.
Showing 10 out of 53 products:
Human PD-L1 ELISA Kit for Sandwich ELISA - ABIN417524
Curry, Lawrence, Burden: Ovarian sympathectomy in the golden hamster: effects on estrous cyclicity and follicular development. in Experimental and clinical endocrinology 1986
Show all 14 Pubmed References
Human PD-L1 ELISA Kit for Sandwich ELISA - ABIN577883
Atesoglu, Tarkun, Demirsoy, Geduk, Mehtap, Batman, Kaya, Cekmen, Gulbas, Hacıhanefioglu: Soluble Programmed Death 1 (PD-1) Is Decreased in Patients With Immune Thrombocytopenia (ITP): Potential Involvement of PD-1 Pathway in ITP Immunopathogenesis. in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 2014
Human PD-L1 ELISA Kit for Sandwich ELISA - ABIN579638
Baral, Ye, Jiang, Yao, Mao: B7-H3 and B7-H1 expression in cerebral spinal fluid and tumor tissue correlates with the malignancy grade of glioma patients. in Oncology letters 2014
Positive expression of PD-L1 may be a useful prognostic marker in breast cancer [META-ANALYSIS].
Authors quantified programmed cell death protein 1 (PD-1 (show PDCD1 ELISA Kits))/programmed cell death-ligand 1, vascular endothelial growth factor (VEGF (show VEGF ELISA Kits))-A/VEGF (show VEGFA ELISA Kits)-C (show VEGFC ELISA Kits) expressions in lymph nodes of 103 patients who underwent sentinel lymph node biopsy.
We found that PD-L1 expression was upregulated following TGF-beta (show TGFB1 ELISA Kits) induction; in contrast, it was downregulated by TGF-beta (show TGFB1 ELISA Kits) receptor-kinase inhibitors and the MET process. Furthermore, chemo-treatment increased TGF-beta (show TGFB1 ELISA Kits) expression and enhances PD-L1 expression via autocrine TGF-beta (show TGFB1 ELISA Kits) induced EMT (show ITK ELISA Kits). Analysis of clinical samples revealed a significant relationship between PD-L1 expression and EMT (show ITK ELISA Kits) status
Increased PD-L1 expression is associated with gastric cancer.
-L1 immunopositivity was seen in a quarter of non-small cell lung carcinomas patients in India. PDL1 positivity on immune cells may be associated with better prognosis in resected non-small cell lung carcinomas
Studies indicate that programmed cell death 1 ligand 1 protein (PD-L1) expression may be very heterogeneous [Review].
Programmed cell death 1 ligand 1 protein (PD-L1) expression significantly correlates with overall mutational load and KRAS protein mutational status in pulmonary sarcomatoid carcinomas.
High PD-L1 expression is associated with diffuse gliomas differs with IDH mutation.
PD-L1 expression in melanoma tumor cells is lower than NSCLC or renal cell carcinoma cells. The higher response rate in melanoma patients treated with PD-1 (show PDCD1 ELISA Kits) inhibitors is likely related to PD-L1 in tumor-associated inflammatory cells. Further studies are warranted to validate the predictive role of inflammatory cell PD-L1 expression in melanoma and determine its biological significance
PD-L1 expression was measured in paired tumor tissue samples collected at different dates and lesions from non-small cell lung cancer patients; there was a statistically significant correlation in PD-L1 proportion scores, with a 67% concordance rate when samples were categorized into positive and negative PD-L1 expression groups
an enhanced expression of PD-L1 was observed besides an increased production of IFN-gamma (show IFNG ELISA Kits) by TH2 cells.
Study demonstrated that PD-L1 expression is up-regulated in the salivary glands of female NOD mice during the developmental phase of Sjgren's syndrome, which in turn hinders the development and onset of this disease in a negative feedback fashion.
PD-L1 expression on tumor cells suppressed antigen-driven TNF (show TNF ELISA Kits) production by CD8 (show CD8A ELISA Kits)(+) T cells, which could be antagonized through PD-1 (show PDCD1 ELISA Kits) blockade
B7-H1 suppresses p38 MAPK (show MAPK14 ELISA Kits) activation by sequestering DNA-PKcs (show PRKDC ELISA Kits) in order to preserve T cell survival
Anti-PD-1 (show PDCD1 ELISA Kits)/PD-L1 therapy inhibited CMT167 orthotopic lung tumors by 95%. .Silencing PD-L1 expression in CMT167 cells resulted in smaller orthotopic tumors that remained sensitive to anti-PD-L1 therapy, whereas implantation of CMT167 cells into PD-L1(-) mice blocked orthotopic tumor growth, indicating a role for PD-L1 in both the cancer cell and the microenvironment.
Combination therapies that depend on checkpoint inhibitor antibodies (Abs) such as for PD-1 (show PDCD1 ELISA Kits) or its ligand (PD-L1) together with immune stimulatory agonist Abs like anti-OX40 (show TNFRSF4 ELISA Kits) are being tested in the clinic to achieve improved antitumor effects
In estrogen receptor (show ESR1 ELISA Kits) negative breast cancer cells targeting of IL-17A (show IL17A ELISA Kits) inhibited PDL1 expression in the tumor microenvironment, decreasing the percentage of Treg cells in tumor-infiltrating lymphocytes, and promoting CD4 (show CD4 ELISA Kits)+ and CD8 (show CD8A ELISA Kits)+ T cells to secrete interferon gamma (show IFNG ELISA Kits).
Squamous cell carcinomas escape immune surveillance via inducing chronic activation and exhaustion of CD8 (show CD8A ELISA Kits)+ T Cells co-expressing PD-1 (show PDCD1 ELISA Kits) and LAG-3 (show LAG3 ELISA Kits) inhibitory receptors.
Genetic ablation of a single immune-regulatory molecule in this model [i.e., B7-homolog 1 (B7-H1, PD-L1)] not only significantly increased incidence of spontaneous CNS autoimmunity and aggravated disease course, especially in the later stages of disease, but also importantly resulted in encephalitogenic T-cell infiltration and lesion formation in normally unaffected brain regions.
Studied the possible role of PD-L1 on malignant melanoma initiating cells (MMICs). Found blocking of PD-L1 in melanoma cell lines impaired tumorsphere formation and induced the apoptosis. Also, blocking PD-L1 inhibited tumor growth in vivo.
This study provides novel information for the understanding of signalling through PD-L1.
These results suggest that the soluble recombinant proteins may be used to prepare monoclonal antibodies to block the PD-1 (show PDCD1 ELISA Kits)/PD-L1 pathway.
role of programmed death ligand-1 (PD-L1) during porcine circovirus type 2 (PCV2) infection and porcine circovirus associated diseases (PCVAD) development
These data suggest that overexpression of PD-L1 and PD-L2 (show PDCD1LG2 ELISA Kits) mRNA is one mechanism by which immunosupression of postweaning multisystemic wasting syndrome pigs occurs.
Retinal PLD1 expression is enhanced in radial fibers of Muller cells with age. This finding suggests that PLD1 plays an important role in signal transduction of glial cells and neuronal cells in the retina.
A porcine PD-L1 molecule was cloned using RACE (rapid amplification of cDNA ends) technology and sequenced (GenBank # AY837780); it showed high sequence homology with human PD-L1.
Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
B7 homolog 1
, CD274 antigen
, PDCD1 ligand 1
, programmed cell death 1 ligand 1
, programmed death ligand 1
, CD274 molecule
, programmed cell death ligand 1