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Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. Additionally we are shipping CENPI Kits (27) and CENPI Proteins (8) and many more products for this protein.
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CENPI is overexpressed in colorectal cancer (CRC) and functions as oncogene in modulating CRC cell migration, invasion and epithelial-mesenchymal transition process.
CENP-C and CENP-I are key factors connecting kinetochore to CENP-A assembly.
mutation in LRPAP1 is associated with high myopia. Further studies are expected to evaluate the pathogenicity of the variants in CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2.
We conclude that the dual activities of Aurora B and CENP-I generate a molecular switch that maintains a robust spindle checkpoint signal at prometaphase kinetochores until they attain mature attachments to microtubules.
demonstrates that CENPI, a centromere protein that localizes to the inner kinetochore structure, is a human autoantigen. The significance of anti-CENPI autoantibodies could be relevant in scleroderma patients as a marker for autoimmune liver disease
The CENP-H-I complex may function, in part, as a marker directing CENP-A deposition to centromeres.
the vertebrate KNL1 counterpart is essential for chromosome segregation and is required to localize a subset of outer kinetochore proteins.
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone.
centromere protein I
, follicle-stimulating hormone primary response protein 1
, FSH primary response 1
, FSH primary response protein 1
, follicle-stimulating hormone primary response protein
, interphase centromere complex protein 19
, leucine-rich primary response protein 1
, Follicle stimulating hormone primary response gene 1 (Leucine - rich primary resonse gene 1)
, FSH primary response (LRPR1 homolog, rat) 1