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in mole pregnancy, levels at baseline, first, second, and third weeks post-evacuation predict persistent disease
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carriers of minor alleles of CGB had a reduced risk of recurrent miscarriage
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the accumulated data indicate that only mutations with neutral or mild functional consequences might be tolerated in the major hCG-beta genes CGB5 and CGB8.
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Carriage of particular variants in the promoter of the CGB5 gene seems to protect against recurrent miscarriage.
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compared the human (45,165 bp) and chimpanzee (39,876 bp) LHB/CGB regions and hereby present evidence for structural variation resulting in discordant number of CGB genes (6 in human, 5 in chimpanzee)
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Data indicate the diagnostic criteria of chorionic gonadotropin beta subunit (beta-hCG) and alpha-Fetoprotein (alphaFP) in CSF and serum, which may advance the early and formal diagnosis of intracranial germ cell tumors (ICGCTs).
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Genetic variation within the CGB5 gene is associated with recurrent spontaneous abortion risk in Chinese women.
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TGF-beta enhances hCG-beta expression in glioblastoma.
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This study showed a link between low maternal serum hCG levels and cryptorchidism in boys from uncomplicated pregnancy.
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Elevated serum human chorionic gonadotropin is associated with germ-cell tumours.
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The effect of human chorionic gonadotropin (hCG), an LH receptor agonist, on APP beta-cleavage in the SH-SY5Y neuroblastoma cell line.
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Down-regulation of MTA3 and up-regulation of CGB5 and Snail are associated with preeclampsia.
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Serum hCG concentrations were negatively associated with maternal prepregnancy body mass index.
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PGDH activity was low before the ovulatory hCG stimulus, peaked 12-24 h after hCG, and was low again 36 h after hCG administration.
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Our finding may represent a novel methylation allelic polymorphism or gain of imprinting in CGB5 promoter leading to expressional silencing of paternal alleles and increasing susceptibility to pregnancy loss.
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The ISOBM TD-7 Workshop on hCG and related molecules. Towards user-oriented standardization of pregnancy and tumor diagnosis
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Two closely spaced Ets-2 binding sites in the proximal promoter of the human chorionic gonadotropin beta5 (hCGbeta5) gene constitute a major enhancer for hCGbeta gene expression in JAr and JEG-3 human choriocarcinoma cells and in mouse NIH3T3 cells.
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Agonists and antagonists will require the presence of other portions of hCGbeta in addition to the determinant loop/seat belt.
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Increasing concentrations of Sp1, Sp3, and AP-2alpha enhance transcription of CGbeta in differentiating term trophoblasts, whereas a different combination of factors may control expression in early placentas.
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OKL38 may function as an effector for human chorionic gonadotropin protection against mammary carcinogenesis.
