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The protein encoded by IBTK binds to Bruton's tyrosine kinase (BTK) and downregulates BTK's kinase activity. Additionally we are shipping and many more products for this protein.
Showing 10 out of 35 products:
Human Polyclonal IBTK Primary Antibody for IP, WB - ABIN4320774
Willy, Young, Mosley, Gawrieh, Stevens, Masuoka, Wek: Function of inhibitor of Bruton's tyrosine kinase isoform α (IBTKα) in nonalcoholic steatohepatitis links autophagy and the unfolded protein response. in The Journal of biological chemistry 2017
Data suggest that IBTKalpha is (a) localized in hepatocytes in endoplasmic reticulum (ER), (b) associates with specific proteins (LC3b (show MAP1LC3B Antibodies), SEC16A (show SEC16A Antibodies), SEC31A (show SEC31A Antibodies)), and (c) plays role in autophagy. Progression of nonalcoholic fatty liver disease is associated with changes in liver: (a) up-regulation of expression of IBTKalpha, (b) unfolded protein response, (c) ER stress, and (d) inhibition of autophagy.
CRL3 (show IL31RA Antibodies)(IBTK) is a novel ubiquitin ligase with regulatory roles in cellular pathways, such as the Pdcd4 (show PDCD4 Antibodies)-dependent translation of mRNAs
Depletion of IBTKalpha by short hairpin RNA reduced viability of cultured cells coincident with increased caspase 3 (show CASP3 Antibodies)/7 cleavage, suggesting that IBTKalpha is a key regulator in determining cell fate during the UPR.
A novel pathway of Btk regulation via protein kinase C phosphorylation of IBtkgamma.
three novel (Ala347fsX55, I355T, and Thr324fsX24) mutations in Bruton's tyrosine kinase (show BTK Antibodies) in patients with X-linked agammaglobulinemia
The IBTK gene encodes the proteins IBtk-alpha, beta and gamma that regulate the B cell receptor signalling through Bruton's tyrosine kinase (show BTK Antibodies), which promotes B cell survival and differentiation.
The protein encoded by this gene binds to Bruton's tyrosine kinase (BTK) and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription.
inhibitor of Bruton agammaglobulinemia tyrosine kinase
, inhibitor of Bruton's tyrosine kinase
, inhibitor of Bruton tyrosine kinase-like
, BTK-binding protein
, Bruton agammaglobulinemia tyrosine kinase inhibitor
, inhibitor of Bruton tyrosine kinase
, inhibitor of Bruton's tyrosine kinase-alpha
, inhibitor of Bruton's tyrosine kinase-beta
, inhibitor of Bruton's tyrosine kinase-gamma