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The protein encoded by ID1 is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors.
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Human Monoclonal ID1 Primary Antibody for ELISA, WB - ABIN561409
Chen, Forootan, Gosney, Forootan, Ke: Increased expression of Id1 and Id3 promotes tumorigenicity by enhancing angiogenesis and suppressing apoptosis in small cell lung cancer. in Genes & cancer 2014
Human Monoclonal ID1 Primary Antibody for IF, ELISA - ABIN561410
Phi, Choi, Lim, Lee, Wang, Park, Kim: ID3 contributes to cerebrospinal fluid seeding and poor prognosis in medulloblastoma. in BMC cancer 2013
Gain and loss of id1 function in vivo demonstrated that Id1 promotes stem cell quiescence. The increased id1 expression observed in neural stem cells in response to injury appeared independent of inflammatory signals.
We show that expression of Id-1 (show IDH1 Antibodies), a negative regulator of myogenesis, is enhanced in Dnmt1 (show DNMT1 Antibodies)-deficient cultures, leading to enhanced transdifferentiation of myoblasts toward the osteogenic lineage. Thus, these studies demonstrate that Dnmt1 (show DNMT1 Antibodies) influences cellular identity and determines lineage fidelity.
a loss of CULLIN3 represents a common signaling node for controlling the activity of intracellular WNT (show WNT2 Antibodies) and SHH (show SHH Antibodies) signaling pathways mediated by ID1
These results reveal a E2F1 (show E2F1 Antibodies)/miR-17-92/ENH1 (show PDLIM5 Antibodies)/Id1 regulatory axis during myogenesis.
Id1 enables both Lewis lung carcinoma cells and the host microenvironment for an effective liver colonization.
adipose tissue-specific overexpression of Id1 causes age-associated and high-fat diet-induced obesity in mice. Id1 suppresses BAT (show BAAT Antibodies) thermogenesis by binding to and suppressing PGC1alpha transcriptional activity. Lack of Id1 increases beige (show LYST Antibodies) gene and Ucp1 (show UCP1 Antibodies) expression in the WAT in response to cold exposure. Furthermore, brown-like differentiation is increased in Id1-deficient mouse embryonic fibroblasts.
If Gfi1 (show ZNF163 Antibodies) levels fall below a threshold, Id1 expression increases and renders E2A (show TCF3 Antibodies) unable to function, which prevents hematopoietic progenitors from engaging along the B lymphoid lineage
Id1 may promote cell cycle progression of endothelial progenitor cells (EPCs), and that Wnt2 (show WNT2 Antibodies) may be important in Id1 regulation of the cell cycle of EPCs.
Differential role of Id1 in MLL (show MLL Antibodies)-AF9 (show MLLT3 Antibodies)-driven leukemia based on cell of origin
Collectively, our results suggest that ENH1 plays an important role in the activation of myogenesis through the repression of Id2 activity.
Data indicate that upregulation of E2-2 (show TCF4 Antibodies) protein markedly attenuated the inhibitor of DNA-binding 1 (ID1)-mediated increase in endothelial progenitor cells (EPCs) proliferation and migration.
ID1 expression was associated with the proliferation, invasion and migration of SACC cells. The observed inhibition of SACC cell growth, invasion and migration following knockdown of ID1 expression in the present study, may have been due to restoration of the balance between oncogenic and tumor-suppressive effects resulting from changes in the expression of downstream genes or associated proteins.
The mutual correlation between the expression level of TWIST1 (show TWIST1 Antibodies) and ID1 might be a critical factor driving the process of the human odontoblasts' differentiation.
Id1 enables lung cancer liver colonization by activating an epithelial mesenchymal transformation program in tumor cells and establishing the pre-metastatic niche.
High ID1 expression is associated with breast cancer.
ID1 expression impacts the sensitivity of colon cancer cells to 5-FU and may be considered as a potential predictive marker in colorectal carcinoma treatment.
Reducing ID1 gene expression reduces metastatic spread of salivary gland neoplasms.
High ID-1 expression is associated with colorectal carcinoma.
ID1 expression was positively related to drug resistance of EGFR (show EGFR Antibodies)-TKI in non-small cell lung cancer.
MVD (show MVD Antibodies) was determined by immunohistochemistry, and the expressions of mRNA and protein of inhibitor of differentiation-1 (ID1) and vascular endothelial growth factor (VEGF (show VEGF Antibodies)) were detected in gastric cancer.
The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene.
inhibitor of DNA binding 1
, DNA-binding protein inhibitor id-1
, inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
, DNA-binding protein inhibitor ID-1
, inhibitor of DNA binding 6
, Inhibitor of DNA binding 1 helix-loop-helix protein (splice varaiation)
, Inhibitor of DNA binding 1, helix-loop-helix protein (splice variation)
, class B basic helix-loop-helix protein 24
, dJ857M17.1.2 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein)
, inhibitor of differentiation 1
, helix-loop-helix protein