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ITSN2 encodes a cytoplasmic protein which contains SH3 domains.
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these data indicate that the ITSN2 exchange factor regulates the activity of Cdc42 during embryo development affecting actin cytoskeleton in Xenopus embryos.
These findings provide the basis for further functional investigations of the ITSN/CR16 complex that may play an important role in actin remodeling and cellular invasion.
ITSN2L interacts with RABEP1 (show RABEP1 Antibodies) and stimulates its degradation in regulation of endocytosis.
The ITSN2 interacts with Eps8 (show EPS8 Antibodies) and stimulates the degradation of Eps8 (show EPS8 Antibodies) proteins.
ITSN1 and ITSN2 bind similar proline-rich ligands but are differentially recognized by SH2 domain-containing proteins.
The sequence and structural alignment of ITSN (show ITSN1 Antibodies)-2L C2 domain with other members of C2 domain protein family indicate its vital cellular roles in membrane trafficking, the generation of lipid-second messengers and activation of GTPases. Moreover, our data show the possible roles of ITSN (show ITSN1 Antibodies)-2L C2 domain in regulating the activity of Cdc42 (show CDC42 Antibodies).
These results highlight a role of Numb (show NUMB Antibodies) for dendritic spine development and synaptic functions with intersectin and EphB2 (show EPHB2 Antibodies).
We show that the PPLP (show PCNT Antibodies) motif of K15 (show KRT15 Antibodies) protein selectively binds the SH3-C domain of an endocytic adaptor protein, Intersectin 2 (ITSN2).
ITSN-2L, a guanine nucleotide exchange factor for Cdc42, regulates different steps of caveola endocytosis in ECs by controlling the temporal and spatial actin polymerization and remodeling sub-adjacent to the plasma membrane.
Intersectin 2 depletion induces the inactivation of Cdc42 (show CDC42 Antibodies)
The isolation and characterization of ESE2 (show ELF5 Antibodies) is reported.
This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. Alternatively spliced transcript variants have been found for this gene that encode three distinct isoforms. Additional variants have been found but their full length nature has not been determined.
, SH3 domain-containing protein 1B
, SH3P18-like WASP-associated protein
, EH and SH3 domains protein 2
, EH domain and SH3 domain regulator of endocytosis 2
, Eh domain, SH3 domain regulator of endocytosis 2
, SH3 domain protein 1B