anti-Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Antibodies

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Additionally we are shipping IDH2 Proteins (20) and IDH2 Kits (16) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
IDH2 3418 P48735
IDH2 269951 P54071
IDH2 361596 P56574
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Top anti-IDH2 Antibodies at

Showing 10 out of 122 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-IDH2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:12500  Positive Control:  Human Muscle 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated IHC (p), WB Anti- IDH2 Picoband antibody, IHC(P) IHC(P): Rat Intestine Tissue Anti- IDH2 Picoband antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue 100 μg Log in to see 4 to 6 Days
Human Mouse Un-conjugated ELISA, IHC, WB Immunoperoxidase of monoclonal antibody to IDH2 on formalin-fixed paraffin-embedded human colon (antibody concentration 3 µg/mL).  Detection limit for recombinant GST tagged IDH2 is approximately 0.03 ng/mL as a capture antibody. 100 μg Log in to see 8 to 11 Days
Human Rabbit Un-conjugated WB Western blot analysis of IDH2 expression in HEK293T (A), Raw264.7 (B), PC12 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
Human Goat Un-conjugated ELISA, IHC, WB ABIN571275 (0.1µg/ml) staining of Human Heart lysate (35µg protein in RIPA buffer). Detected by chemiluminescence. ABIN571275 (0.1µg/ml) staining of Mouse (A), Rat (B) and Pig (C) Heart lysates (35µg protein in RIPA buffer). Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: IDH2 Antibody [NBP1-85784] - Staining of human cell line U-2 OS shows positivity in mitochondria. Western Blot: IDH2 Antibody [NBP1-85784] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp 0.1 mL Log in to see 10 to 13 Days
Human Mouse Un-conjugated ELISA, IHC, IHC (p), WB Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 11 to 14 Days
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
Bat Goat Un-conjugated ELISA, IHC, IHC (p), WB 50 μg Log in to see 11 to 14 Days
Bat Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days

Top referenced anti-IDH2 Antibodies

  1. Human Polyclonal IDH2 Primary Antibody for ICC, IF - ABIN4321024 : Saha, Gordan, Kleinstiver, Vu, Najem, Yeo, Shi, Kato, Levin, Webber, Damon, Egan, Greninger, McDermott, Garnett, Jenkins, Rieger-Christ, Sullivan, Hezel, Liss, Mizukami, Goyal, Ferrone, Zhu, Joung et al.: Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma. ... in Cancer discovery 2016 (PubMed)
    Show all 3 Pubmed References

  2. Human Monoclonal IDH2 Primary Antibody for IHC (p), ELISA - ABIN561418 : Gambichler, Terras, Kreuter, Skrygan: Altered global methylation and hydroxymethylation status in vulvar lichen sclerosus: further support for epigenetic mechanisms. in The British journal of dermatology 2014 (PubMed)

  3. Cow (Bovine) Polyclonal IDH2 Primary Antibody for WB - ABIN2783282 : Shin, Kil, Park: Silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase by small interfering RNA enhances heat shock-induced apoptosis. in Biochemical and biophysical research communications 2008 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal IDH2 Primary Antibody for ELISA, WB - ABIN4321020 : Abbas, Lugthart, Kavelaars, Schelen, Koenders, Zeilemaker, van Putten, Rijneveld, Löwenberg, Valk: Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value. in Blood 2010 (PubMed)

  5. Human Polyclonal IDH2 Primary Antibody for ICC, IF - ABIN4321022 : Murgia, Nagaraj, Deshmukh, Zeiler, Cancellara, Moretti, Reggiani, Schiaffino, Mann: Single muscle fiber proteomics reveals unexpected mitochondrial specialization. in EMBO reports 2015 (PubMed)

  6. Human Polyclonal IDH2 Primary Antibody for ChIP, IF - ABIN6142146 : Wang, Liang, Lian, Liu, Zhao, Xuan, Guo, Liu, Yang, Dong, Liu, Liu, Zhang: Identification of proteins responsible for adriamycin resistance in breast cancer cells using proteomics analysis. in Scientific reports 2016 (PubMed)

More Antibodies against IDH2 Interaction Partners

Arabidopsis thaliana Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. Leaf IDH activity reduced by 43% in mutant

Human Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. Mutations in the IDH2 gene were found in 7.5% of cases, with a predominance of the nonsynonymous R172K and R172W mutations

  2. IDH1 or IDH2 mutations play a limited role in the development of ESCC. 2HG is potentially synthesized to high levels in the absence of IDH1 and IDH2 mutations, and this may correlate with progression of ESCCs.

  3. x-ray crystallography of mutant IDH2 binding of an inhibitor (AG-881) to an allosteric site, and compared to IDH1 allosteric site binding

  4. The role of IDH2 mutations in tumorigenesis in gliomas is reviewed.

  5. IDH2 mutations are associated with 1p/19q codeletion in diffuse adult glioma.

  6. pharmacogenetics: observations uncover a mechanism of acquired resistance to a targeted therapy and underscore the importance of 2-hydroxyglutarate production in the pathogenesis of IDH2-mutant malignancies

  7. In this review, we summarize current knowledge regarding the function of normal and mutated IDH(socitrate dehydrogenases 1 and 2 ), explain the possible mechanisms through which these mutations might drive malignant transformation of progenitor cells in the central nervous system, and provide a comprehensive review of potential treatment strategies for IDH-mutated malignancies, focusing on gliomas.

  8. We validated the presence of IDH2 R172 hotspot mutations and PIK3CA hotspot mutations in 100% and 67% of solid papillary breast carcinoma with reverse polarity tested, respectively

  9. Identification of driver and subclonal mutations in ASXL1 and IDH1/IDH2 genes in an Argentine series of patients with myelofibrosis.

  10. an overview of the biological and clinical implications of IDH1 and IDH2 mutations in acute myeloid leukemia (review).

  11. genetic association studies in population in Czech Republic: Data suggest that mutations in IDH1 and IDH2 are associated with AML (acute myeloid leukemia); IDH1/2-based monitoring of MRD (minimal residual disease) appears to have prognostic value for residual disease in AML patients.

  12. There was significant prognostic difference among the 4 glioma subtypes. Combined IDH and TERT gene mutation analysis may be useful for prognostic subgrouping. Notably, IDH1 wild-type cases can be further subdivided into TERT(+ ) or (-) subgroups with significant prognostic difference.

  13. Generation of 2-hydroxyglutarate by mutated IDH1/2 leads to the activation of mTOR by inhibiting KDM4A.

  14. Enasidenib reduces 2-hydroxyglutarate levels in patients with relapsed or refractory (R/R) acute myeloid leukemia harboring either IDH2-R140 or IDH2-R172 mutations

  15. IDH2 mutation is associated with glioma progression.

  16. No correlation between IDH1/2 mutation status and sensitivity for NAMPT inhibitors was observed. Strikingly, higher methylation of the NAPRT promoter was observed in high-grade versus low-grade chondrosarcomas. In conclusion, this study identified NAMPT as a potential target for treatment of chondrosarcoma

  17. This study furthers implementation of clinical genomics in MDS and identifies TP53 and IDH2 as targets for pre- or post-transplant therapy

  18. Results highlight that non-canonical IDH mutations are relatively common in grade II and III gliomas: it is therefore important to analyze exon 4 of both IDH1 and IDH2 in these tumors. They also demonstrate that all IDH mutations, including the non-canonical ones are clonally distributed, a finding consistent with their driver role in gliomagenesis.

  19. IDH2(mut) patients had a higher risk of leukemic transformation. The co-occurrence of DNMT3A or SRSF2 mutations was found to be increased in IDH2(mut) patients. IDH2 mutations were associated with significantly worse OS and LFS amongst patients with low-risk MDS by IPSS grouping.

  20. Patients with grade II gliomas showed a higher rate of IDH1 and IDH2 mutations and seizures than patients with grade III and IV gliomas--{REVIEW}

Mouse (Murine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. IDH2 deficiency downregulated pro-inflammatory mediators via modulation of the ERK and NF-kappaB pathways

  2. IDH2 knock out mice exhibit a decreased susceptibility to lipopolysaccharide (LPS)-induced lung injury. Depletion of IDH2 attenuates LPS-induced inflammatory response.

  3. role in maintaining the spinal structure by affecting the homeostatic balance between osteoclasts and osteoblasts

  4. our findings highlight the role of IDH2 in skin melanogenesis in association with mitochondrial ROS and suggest unique therapeutic strategies for the prevention of skin pigmentation.

  5. Data (including data from studies using knockout mice) suggest that IDH2 plays role in modulating liver fatty acid metabolism in dietary fructose-induced NAFLD (non-alcoholic fatty liver disease). This study was conducted in female mice; previous studies suggest that women are more prone to develop metabolic syndromes in response to fructose-sweetened beverages.

  6. present study supports the central role of idh2 deficiency in inducing oxidative stress resulting from acrolein-induced disruption of mitochondrial redox status in the lung

  7. IDH2 deficiency leads to increased mitochondrial ROS levels, activation of NF-kappaB and apoptosis of IEC in DSS-induced colitis.

  8. present study, we provided a role for IDH2 in protection against UVB-induced skin damage and a new connection between IDH2 and DeltaNp63.

  9. The disruption of IDH2 attenuates age-associated hepatic steatosis by the activation of p38/cJun NH2-terminal kinase (JNK) and p53, presumably induced by the elevation of mitochondrial reactive oxygen species (ROS), which in turn resulted in the suppression of hepatic lipogenesis and inflammation via the upregulation of fibroblast growth factor 21 (FGF21) and the inhibition of NFkappaB signaling pathways.

  10. We propose that D2-HG promotes cardiac dysfunction by impairing alpha-ketoglutarate dehydrogenase and induces histone modifications in an ACL-dependent manner.Combining mathematical modeling and in vivo as well as ex vivo studies, we found that increased amounts of the oncometabolite d-2-hydroxyglutarate (D2-HG), produced by IDH2 mutant leukemic cells, cause contractile dysfunction in the heart

  11. Increased obesity resistance and insulin sensitivity in mice lacking the IDH2 gene has been documented.

  12. treatment with Mito-TEMPO, a mitochondrial-specific superoxide scavenger, recovered mitochondrial fission-fusion imbalance and blunted mitochondrial superoxide production, and reduced the IDH2 knockdown-induced decrease in MnSOD expression, eNOS phosphorylation and NO production in endothelial cells

  13. Idh2R140Q mice displayed significantly elevated 2HG levels.

  14. These data support a significant role for increased oxidative stress as a result of compromised mitochondrial antioxidant defenses in modulating life span in mice, and thus support the oxidative stress theory of aging.

  15. Findings demonstrate that IDH2 contributes to degeneration of the DA neuron in the neurotoxin model of Parkinson's Disease.

  16. IDH2 deficiency promotes mitochondrial dysfunction and cardiac hypertrophy in mice.

  17. IDH2 and NPM1 mutations synergize in the development and maintenance of acute myeloid leukemia stem-like cells.

  18. 7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144 leading to atherosclerosis.

  19. These data demonstrate the proto-oncogenic role of mutant IDH2.

  20. The tumor tissue of B16F10 cells transfected with IDH2 antisense cDNA exhibited induction of apoptosis and downregulation of angiogenesis markers.

Cow (Bovine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. The enzyme is highly sensitive to Mg(2+) concentration in the physiological range, pointing to a potential regulatory role of [Mg(2+)] in mitochondrial energy metabolism.

Pig (Porcine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase

  2. analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase

  3. These results suggest that IDPm plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx activity.

IDH2 Antigen Profile

Protein Summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.

Gene names and symbols associated with IDH2

  • isocitrate dehydrogenase subunit 2 (IDH2) antibody
  • isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (IDH2) antibody
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (Idh2) antibody
  • isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (Idh2) antibody
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial S homeolog (idh2.S) antibody
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (idh2) antibody
  • isocitrate dehydrogenase [NADP], mitochondrial (LOC100441867) antibody
  • D2HGA2 antibody
  • E430004F23 antibody
  • F6P23.14 antibody
  • F6P23_14 antibody
  • ICD-M antibody
  • IDH antibody
  • Idh-2 antibody
  • IDH-II antibody
  • IDH2 antibody
  • IDHM antibody
  • IDP antibody
  • IDPm antibody
  • isocitrate dehydrogenase II antibody
  • isocitrate dehydrogenase subunit 2 antibody
  • mNADP-IDH antibody
  • wu:fb33c06 antibody
  • wu:fk31e05 antibody
  • wu:fq43b01 antibody
  • zgc:55485 antibody

Protein level used designations for IDH2

NADP(+)-specific ICDH , isocitrate dehydrogenase [NADP], mitochondrial , oxalosuccinate decarboxylase , ICD-M , IDH , IDP , NADP+-specific isocitrate dehydrogenase , NADPH-specific isocitrate dehydrogenase , isocitrate dehydrogenase 2 (NADP+), mitochondrial , isocitrate dehydrogenase [NADP], mitochondrial-like

816218 Arabidopsis thaliana
3418 Homo sapiens
269951 Mus musculus
327669 Bos taurus
361596 Rattus norvegicus
380013 Xenopus laevis
386951 Danio rerio
397603 Sus scrofa
448026 Xenopus (Silurana) tropicalis
453645 Pan troglodytes
479043 Canis lupus familiaris
701480 Macaca mulatta
100441867 Pongo abelii
431056 Gallus gallus
100726681 Cavia porcellus
100340796 Oryctolagus cuniculus
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