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Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Additionally we are shipping IDH2 Proteins (20) and IDH2 Kits (16) and many more products for this protein.
Showing 10 out of 118 products:
Human Polyclonal IDH2 Primary Antibody for ICC, IF - ABIN4321024
Saha, Gordan, Kleinstiver, Vu, Najem, Yeo, Shi, Kato, Levin, Webber, Damon, Egan, Greninger, McDermott, Garnett, Jenkins, Rieger-Christ, Sullivan, Hezel, Liss, Mizukami, Goyal, Ferrone, Zhu, Joung et al.: Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma. ... in Cancer discovery 2016
Show all 3 Pubmed References
Human Monoclonal IDH2 Primary Antibody for IHC (p), ELISA - ABIN561418
Gambichler, Terras, Kreuter, Skrygan: Altered global methylation and hydroxymethylation status in vulvar lichen sclerosus: further support for epigenetic mechanisms. in The British journal of dermatology 2014
Human Polyclonal IDH2 Primary Antibody for ELISA, WB - ABIN4321020
Abbas, Lugthart, Kavelaars, Schelen, Koenders, Zeilemaker, van Putten, Rijneveld, Löwenberg, Valk: Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value. in Blood 2010
Human Polyclonal IDH2 Primary Antibody for ICC, IF - ABIN4321022
Murgia, Nagaraj, Deshmukh, Zeiler, Cancellara, Moretti, Reggiani, Schiaffino, Mann: Single muscle fiber proteomics reveals unexpected mitochondrial specialization. in EMBO reports 2015
Human Polyclonal IDH2 Primary Antibody for WB - ABIN4890344
Shin, Kil, Park: Silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase by small interfering RNA enhances heat shock-induced apoptosis. in Biochemical and biophysical research communications 2008
Cow (Bovine) Polyclonal IDH2 Primary Antibody for WB - ABIN2783282
Vohwinkel, Lecuona, Sun, Sommer, Vadász, Chandel, Sznajder: Elevated CO(2) levels cause mitochondrial dysfunction and impair cell proliferation. in The Journal of biological chemistry 2011
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Leaf IDH activity reduced by 43% in mutant
We validated the presence of IDH2 R172 hotspot mutations and PIK3CA (show PIK3CA Antibodies) hotspot mutations in 100% and 67% of solid papillary breast carcinoma with reverse polarity tested, respectively
Identification of driver and subclonal mutations in ASXL1 (show ASXL1 Antibodies) and IDH1 (show IDH1 Antibodies)/IDH2 genes in an Argentine series of patients with myelofibrosis.
an overview of the biological and clinical implications of IDH1 (show IDH1 Antibodies) and IDH2 mutations in acute myeloid leukemia (show BCL11A Antibodies) (review).
genetic association studies in population in Czech Republic: Data suggest that mutations in IDH1 (show IDH1 Antibodies) and IDH2 are associated with AML (show RUNX1 Antibodies) (acute myeloid leukemia (show BCL11A Antibodies)); IDH1 (show IDH1 Antibodies)/2-based monitoring of MRD (minimal residual disease) appears to have prognostic value for residual disease in AML (show RUNX1 Antibodies) patients.
There was significant prognostic difference among the 4 glioma subtypes. Combined IDH (show IDH1 Antibodies) and TERT (show TERT Antibodies) gene mutation analysis may be useful for prognostic subgrouping. Notably, IDH1 (show IDH1 Antibodies) wild-type cases can be further subdivided into TERT (show TERT Antibodies)(+ ) or (-) subgroups with significant prognostic difference.
Generation of 2-hydroxyglutarate by mutated IDH1 (show IDH1 Antibodies)/2 leads to the activation of mTOR (show FRAP1 Antibodies) by inhibiting KDM4A (show KDM4A Antibodies).
Enasidenib reduces 2-hydroxyglutarate levels in patients with relapsed or refractory (R/R) acute myeloid leukemia (show BCL11A Antibodies) harboring either IDH2-R140 or IDH2-R172 mutations
IDH2 mutation is associated with glioma progression.
No correlation between IDH1 (show IDH1 Antibodies)/2 mutation status and sensitivity for NAMPT (show NAMPT Antibodies) inhibitors was observed. Strikingly, higher methylation of the NAPRT promoter was observed in high-grade versus low-grade chondrosarcomas. In conclusion, this study identified NAMPT (show NAMPT Antibodies) as a potential target for treatment of chondrosarcoma
This study furthers implementation of clinical genomics in MDS (show PAFAH1B1 Antibodies) and identifies TP53 (show TP53 Antibodies) and IDH2 as targets for pre- or post-transplant therapy
our findings highlight the role of IDH2 in skin melanogenesis in association with mitochondrial ROS (show ROS1 Antibodies) and suggest unique therapeutic strategies for the prevention of skin pigmentation.
Data (including data from studies using knockout mice) suggest that IDH2 plays role in modulating liver fatty acid metabolism in dietary fructose-induced NAFLD (show TSC2 Antibodies) (non-alcoholic fatty liver disease). This study was conducted in female mice; previous studies suggest that women are more prone to develop metabolic syndromes in response to fructose-sweetened beverages.
present study supports the central role of idh2 deficiency in inducing oxidative stress resulting from acrolein-induced disruption of mitochondrial redox status in the lung
IDH2 deficiency leads to increased mitochondrial ROS (show ROS1 Antibodies) levels, activation of NF-kappaB (show NFKB1 Antibodies) and apoptosis of IEC in DSS (show PMP22 Antibodies)-induced colitis.
present study, we provided a role for IDH2 in protection against UVB-induced skin damage and a new connection between IDH2 and DeltaNp63.
The disruption of IDH2 attenuates age-associated hepatic steatosis by the activation of p38 (show CRK Antibodies)/cJun (show JUN Antibodies) NH2-terminal kinase (JNK (show MAPK8 Antibodies)) and p53 (show TP53 Antibodies), presumably induced by the elevation of mitochondrial reactive oxygen species (ROS (show ROS1 Antibodies)), which in turn resulted in the suppression of hepatic lipogenesis and inflammation via the upregulation of fibroblast growth factor 21 (FGF21 (show FGF21 Antibodies)) and the inhibition of NFkappaB signaling pathways.
We propose that D2-HG promotes cardiac dysfunction by impairing alpha-ketoglutarate dehydrogenase (show alphaKGDHC Antibodies) and induces histone modifications in an ACL (show APOC4 Antibodies)-dependent manner.Combining mathematical modeling and in vivo as well as ex vivo studies, we found that increased amounts of the oncometabolite d-2-hydroxyglutarate (D2-HG), produced by IDH2 mutant leukemic cells, cause contractile dysfunction in the heart
Increased obesity resistance and insulin (show INS Antibodies) sensitivity in mice lacking the IDH2 gene has been documented.
treatment with Mito-TEMPO, a mitochondrial-specific superoxide scavenger, recovered mitochondrial fission-fusion imbalance and blunted mitochondrial superoxide production, and reduced the IDH2 knockdown-induced decrease in MnSOD (show SOD2 Antibodies) expression, eNOS (show NOS3 Antibodies) phosphorylation and NO production in endothelial cells
Findings demonstrate that IDH2 contributes to degeneration of the DA neuron in the neurotoxin model of Parkinson's Disease.
The enzyme is highly sensitive to Mg(2 (show MCOLN1 Antibodies)+) concentration in the physiological range, pointing to a potential regulatory role of [Mg(2 (show MCOLN1 Antibodies)+)] in mitochondrial energy metabolism.
Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase (show IDH3B Antibodies)
analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase (show IDH3B Antibodies)
These results suggest that IDPm plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx (show GRX1 Antibodies) activity.
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.
, isocitrate dehydrogenase [NADP], mitochondrial
, oxalosuccinate decarboxylase
, NADP+-specific isocitrate dehydrogenase
, NADPH-specific isocitrate dehydrogenase
, isocitrate dehydrogenase 2 (NADP+), mitochondrial
, isocitrate dehydrogenase [NADP], mitochondrial-like