anti-Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Antibodies

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Additionally we are shipping IDH2 Proteins (20) and IDH2 Kits (16) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
IDH2 3418 P48735
IDH2 269951 P54071
IDH2 361596 P56574
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Top anti-IDH2 Antibodies at antibodies-online.com

Showing 10 out of 118 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-IDH2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:12500  Positive Control:  Human Muscle 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- IDH2 Picoband antibody, IHC(P) IHC(P): Rat Intestine Tissue Anti- IDH2 Picoband antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of IDH2 expression in HEK293T (A), Raw264.7 (B), PC12 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Mouse Un-conjugated ELISA, IHC, WB Immunoperoxidase of monoclonal antibody to IDH2 on formalin-fixed paraffin-embedded human colon (antibody concentration 3 µg/mL).  Detection limit for recombinant GST tagged IDH2 is approximately 0.03 ng/mL as a capture antibody. 100 μg Log in to see 8 to 11 Days
$461.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: IDH2 Antibody [NBP1-85784] - Staining of human cell line U-2 OS shows positivity in mitochondria. Western Blot: IDH2 Antibody [NBP1-85784] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$481.25
Details
Human Rabbit Un-conjugated WB Western Blot: IDH2 Antibody [NBP1-54779] - Titration: 0.2-1 ug/ml, Positive Control: Human Muscle. Western Blot: IDH2 Antibody [NBP1-54779] - Middle region validated by WB using Proximal kidney tubules purfied from cortex at 1:1000. 100 μL Log in to see 8 to 11 Days
$485.88
Details
Bat Goat Un-conjugated ELISA, IHC, IHC (p), WB 50 μg Log in to see 7 to 9 Days
$484.00
Details
Human Goat Un-conjugated ELISA, WB Western Blot: IDH2 Antibody [NBP1-52117] - Analysis of IDH2 in Human Heart lysate (35ug protein in RIPA buffer) using NBP1-52117 at 0.1 ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence. Immunohistochemistry-Paraffin: IDH2 Antibody  - 3.75ug/ml staining of paraffin embedded Human Skeletal Muscle. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 0.1 mg Log in to see 7 to 9 Days
$485.88
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details

IDH2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-IDH2 Antibodies

  1. Human Polyclonal IDH2 Primary Antibody for ICC, IF - ABIN4321024 : Saha, Gordan, Kleinstiver, Vu, Najem, Yeo, Shi, Kato, Levin, Webber, Damon, Egan, Greninger, McDermott, Garnett, Jenkins, Rieger-Christ, Sullivan, Hezel, Liss, Mizukami, Goyal, Ferrone, Zhu, Joung et al.: Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma. ... in Cancer discovery 2016 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal IDH2 Primary Antibody for ICC, IF - ABIN4321022 : Murgia, Nagaraj, Deshmukh, Zeiler, Cancellara, Moretti, Reggiani, Schiaffino, Mann: Single muscle fiber proteomics reveals unexpected mitochondrial specialization. in EMBO reports 2015 (PubMed)

  3. Human Polyclonal IDH2 Primary Antibody for WB - ABIN4890344 : Shin, Kil, Park: Silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase by small interfering RNA enhances heat shock-induced apoptosis. in Biochemical and biophysical research communications 2008 (PubMed)

  4. Human Monoclonal IDH2 Primary Antibody for IHC (p), ELISA - ABIN561418 : Gambichler, Terras, Kreuter, Skrygan: Altered global methylation and hydroxymethylation status in vulvar lichen sclerosus: further support for epigenetic mechanisms. in The British journal of dermatology 2014 (PubMed)

  5. Human Polyclonal IDH2 Primary Antibody for ELISA, WB - ABIN4321020 : Abbas, Lugthart, Kavelaars, Schelen, Koenders, Zeilemaker, van Putten, Rijneveld, Löwenberg, Valk: Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value. in Blood 2010 (PubMed)

  6. Cow (Bovine) Polyclonal IDH2 Primary Antibody for WB - ABIN2783282 : Vohwinkel, Lecuona, Sun, Sommer, Vadász, Chandel, Sznajder: Elevated CO(2) levels cause mitochondrial dysfunction and impair cell proliferation. in The Journal of biological chemistry 2011 (PubMed)
    Show all 2 Pubmed References

More Antibodies against IDH2 Interaction Partners

Arabidopsis thaliana Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. Leaf IDH activity reduced by 43% in mutant

Human Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. No correlation between IDH1 (show IDH1 Antibodies)/2 mutation status and sensitivity for NAMPT (show NAMPT Antibodies) inhibitors was observed. Strikingly, higher methylation of the NAPRT promoter was observed in high-grade versus low-grade chondrosarcomas. In conclusion, this study identified NAMPT (show NAMPT Antibodies) as a potential target for treatment of chondrosarcoma

  2. This study furthers implementation of clinical genomics in MDS (show PAFAH1B1 Antibodies) and identifies TP53 (show TP53 Antibodies) and IDH2 as targets for pre- or post-transplant therapy

  3. Results highlight that non-canonical IDH mutations are relatively common in grade II and III gliomas: it is therefore important to analyze exon 4 of both IDH1 and IDH2 in these tumors. They also demonstrate that all IDH mutations, including the non-canonical ones are clonally distributed, a finding consistent with their driver role in gliomagenesis.

  4. IDH2(mut (show MUT Antibodies)) patients had a higher risk of leukemic transformation. The co-occurrence of DNMT3A (show DNMT3A Antibodies) or SRSF2 (show SRSF2 Antibodies) mutations was found to be increased in IDH2(mut (show MUT Antibodies)) patients. IDH2 mutations were associated with significantly worse OS and LFS amongst patients with low-risk MDS (show PAFAH1B1 Antibodies) by IPSS grouping.

  5. Patients with grade II gliomas showed a higher rate of IDH1 (show IDH1 Antibodies) and IDH2 mutations and seizures than patients with grade III and IV gliomas--{REVIEW}

  6. The aim of this study is to determine the prevalence of IDH (show IDH1 Antibodies) mutations and EGFR (show EGFR Antibodies) amplifications in the population of the northeast region of Morocco and then to compare the results with other studies.

  7. this epigenetic antagonism precedes malignant transformation and can be observed in preleukemic LSK (show LCK Antibodies) cells from Idh2(R140Q) or Dnmt3a (show DNMT3A Antibodies)(R882H) single-mutant and Idh2(R140Q)/Dnmt3a (show DNMT3A Antibodies)(R882H) double-mutant mice. IDH (show IDH1 Antibodies)/DNMT3A (show DNMT3A Antibodies) double-mutant acute myeloid leukemia (show BCL11A Antibodies) (AML (show RUNX1 Antibodies))manifested upregulation of a RAS signaling signature and displayed unique sensitivity to MEK (show MAP2K1 Antibodies) inhibition ex vivo as compared with AMLs with either single mutation.

  8. IDH2 R172 mutations may be the only variants present in angioimmunoblastic T-cell lymphoma because of their capacity to produce significant amounts of the oncometabolite 2-hydroxyglutarate in the cell of origin of this disease

  9. IDH2 mutation is associated with 1p19q co-deletion diffuse glioma.

  10. In primary human acute myeloid leukemia (show BCL11A Antibodies) samples, the 2-hydroxyglutarate levels observed in samples with mutant IDH1 (show IDH1 Antibodies) or IDH2 status were higher than those observed in samples without an enzyme mutation, similar to what was observed in the original study (Figure 5C; Ward et al., 2010).

Mouse (Murine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. IDH2 deficiency leads to increased mitochondrial ROS (show ROS1 Antibodies) levels, activation of NF-kappaB (show NFKB1 Antibodies) and apoptosis of IEC in DSS (show PMP22 Antibodies)-induced colitis.

  2. present study, we provided a role for IDH2 in protection against UVB-induced skin damage and a new connection between IDH2 and DeltaNp63.

  3. The disruption of IDH2 attenuates age-associated hepatic steatosis by the activation of p38 (show CRK Antibodies)/cJun (show JUN Antibodies) NH2-terminal kinase (JNK (show MAPK8 Antibodies)) and p53 (show TP53 Antibodies), presumably induced by the elevation of mitochondrial reactive oxygen species (ROS (show ROS1 Antibodies)), which in turn resulted in the suppression of hepatic lipogenesis and inflammation via the upregulation of fibroblast growth factor 21 (FGF21 (show FGF21 Antibodies)) and the inhibition of NFkappaB signaling pathways.

  4. We propose that D2-HG promotes cardiac dysfunction by impairing alpha-ketoglutarate dehydrogenase (show alphaKGDHC Antibodies) and induces histone modifications in an ACL (show APOC4 Antibodies)-dependent manner.Combining mathematical modeling and in vivo as well as ex vivo studies, we found that increased amounts of the oncometabolite d-2-hydroxyglutarate (D2-HG), produced by IDH2 mutant leukemic cells, cause contractile dysfunction in the heart

  5. Increased obesity resistance and insulin (show INS Antibodies) sensitivity in mice lacking the IDH2 gene has been documented.

  6. treatment with Mito-TEMPO, a mitochondrial-specific superoxide scavenger, recovered mitochondrial fission-fusion imbalance and blunted mitochondrial superoxide production, and reduced the IDH2 knockdown-induced decrease in MnSOD (show SOD2 Antibodies) expression, eNOS (show NOS3 Antibodies) phosphorylation and NO production in endothelial cells

  7. Findings demonstrate that IDH2 contributes to degeneration of the DA neuron in the neurotoxin model of Parkinson's Disease.

  8. IDH2 deficiency promotes mitochondrial dysfunction and cardiac hypertrophy in mice.

  9. IDH2 and NPM1 (show GJA1 Antibodies) mutations synergize in the development and maintenance of acute myeloid leukemia (show BCL11A Antibodies) stem-like cells.

  10. 7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144 leading to atherosclerosis.

Cow (Bovine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. The enzyme is highly sensitive to Mg(2 (show MCOLN1 Antibodies)+) concentration in the physiological range, pointing to a potential regulatory role of [Mg(2 (show MCOLN1 Antibodies)+)] in mitochondrial energy metabolism.

Pig (Porcine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase (show IDH3B Antibodies)

  2. analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase (show IDH3B Antibodies)

  3. These results suggest that IDPm plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx (show GRX1 Antibodies) activity.

IDH2 Antigen Profile

Protein Summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.

Gene names and symbols associated with IDH2

  • isocitrate dehydrogenase subunit 2 (IDH2) antibody
  • isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (IDH2) antibody
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (Idh2) antibody
  • isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (Idh2) antibody
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial S homeolog (idh2.S) antibody
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (idh2) antibody
  • isocitrate dehydrogenase [NADP], mitochondrial (LOC100441867) antibody
  • D2HGA2 antibody
  • E430004F23 antibody
  • F6P23.14 antibody
  • F6P23_14 antibody
  • ICD-M antibody
  • IDH antibody
  • Idh-2 antibody
  • IDH-II antibody
  • IDH2 antibody
  • IDHM antibody
  • IDP antibody
  • IDPm antibody
  • isocitrate dehydrogenase II antibody
  • isocitrate dehydrogenase subunit 2 antibody
  • mNADP-IDH antibody
  • NAD+ DEPENDENT ISOCITRATE DEHYDROGENASE SUBUNIT 2 antibody
  • wu:fb33c06 antibody
  • wu:fk31e05 antibody
  • wu:fq43b01 antibody
  • zgc:55485 antibody

Protein level used designations for IDH2

NADP(+)-specific ICDH , isocitrate dehydrogenase [NADP], mitochondrial , oxalosuccinate decarboxylase , ICD-M , IDH , IDP , NADP+-specific isocitrate dehydrogenase , NADPH-specific isocitrate dehydrogenase , isocitrate dehydrogenase 2 (NADP+), mitochondrial , isocitrate dehydrogenase [NADP], mitochondrial-like

GENE ID SPECIES
816218 Arabidopsis thaliana
3418 Homo sapiens
269951 Mus musculus
327669 Bos taurus
361596 Rattus norvegicus
380013 Xenopus laevis
386951 Danio rerio
397603 Sus scrofa
448026 Xenopus (Silurana) tropicalis
453645 Pan troglodytes
479043 Canis lupus familiaris
701480 Macaca mulatta
100441867 Pongo abelii
431056 Gallus gallus
100726681 Cavia porcellus
100340796 Oryctolagus cuniculus
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