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The protein encoded by LRR1 contains a leucine-rich repeat (LRR).
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Results identify the CRL2 (show CRLF2 Antibodies)(LRR-1) ubiquitin ligase as a conserved regulator of Cip/Kip (show CIB1 Antibodies) CKIs that promotes the degradation of C. elegans CKI-1 and human p21 (show CDKN1A Antibodies).
The protein encoded by this gene contains a leucine-rich repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily. Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2), which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades. Alternative splicing results in multiple transcript variants.
peptidylprolyl isomerase (cyclophilin) like 5
, peptidylprolyl isomerase-like 5
, 4-1BB-mediated signaling molecule
, 4-1BB-mediated-signaling molecule
, LRR-repeat protein 1
, cyclophilin-like 5
, leucine-rich repeat protein 1
, peptidylprolyl isomerase (cyclophilin)-like 5