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M6PR encodes a member of the P-type lectin family. Additionally we are shipping M6PR Kits (11) and M6PR Proteins (11) and many more products for this protein.
Showing 10 out of 72 products:
Human Polyclonal M6PR Primary Antibody for ELISA, WB - ABIN561704
Steffan, Williams, Welbourne, Cardelli: HGF-induced invasion by prostate tumor cells requires anterograde lysosome trafficking and activity of Na+-H+ exchangers. in Journal of cell science 2010
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Cow (Bovine) Polyclonal M6PR Primary Antibody for ELISA - ABIN408673
Frei, Jeon, Kilcher, Moest, Henning, Jost, Plückthun, Mercer, Aebersold, Carreira, Wollscheid: Direct identification of ligand-receptor interactions on living cells and tissues. in Nature biotechnology 2012
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In light of existing report suggesting critical role of Nef-GCC185 (show GCC2 Antibodies) interaction reveals valuable mechanistic insights affecting specific protein transport pathway in docking of late endosome derived Rab9 (show RAB9A Antibodies) bearing transport vesicle at TGN (show TG Antibodies) elucidating role of Nef during viral pathogenesis.
Results suggest that Rab (show HRB Antibodies) protein Rab29 (show RAB7L1 Antibodies) is essential for the integrity of the trans-Golgi network (TGN (show TG Antibodies)) and participates in the retrograde trafficking of mannose-6-phosphate receptor (M6PR).
These data indicate that clathrin is required for the function of AP-1 (show FOSB Antibodies)- and GGA-coated carriers at the trans-Golgi network but may be dispensable for outward traffic en route to the plasma membrane.
Sortilin (show SORT1 Antibodies) is a new alpha-Gal A receptor expressed in renal endothelial cells and that this receptor together with the M6PR (show IGF2R Antibodies) is able to internalize circulating alpha-Gal A.
Mannose receptor (MR) engagement by mesothelin (show MSLN Antibodies) GPI (show GNPDA1 Antibodies) anchor polarizes tumor-associated macrophages and is blocked by anti-MR human recombinant antibody
sorting of the CD-MPR in late endosomes requires a distinct di-aromatic motif with only limited possibilities for variations
We conclude that the CI-MPR (show IGF2R Antibodies) participates in lysosomal and granular targeting of serglycin (show SRGN Antibodies) and basic proteins such as lysozyme (show LYZ Antibodies) associated with the proteoglycan (show Vcan Antibodies) in hematopoietic cells.
sortilin (show SORT1 Antibodies) and mannose-6-phosphate receptors recycle to the TGN (show TG Antibodies) in SNX1 (show SNX1 Antibodies)-dependent carriers, which we named endosome-to-TGN (show TG Antibodies) transport carriers
Missorting of cathepsin D (show CTSD Antibodies) in GARP (show CNGB1 Antibodies)-depleted cells results from accumulation of recycling MPRs in a population of light, small vesicles downstream of endosomes.
Data demonstrate that Rab31 (show RAB31 Antibodies) is required for transport of mannose 6-phosphate receptors from the trans-Golgi network to endosomes and for the Golgi/TGN (show TG Antibodies) organization.
Finally, Chlamydia trachomatis infection interferes with the SNX5 (show SNX5 Antibodies):cation-independent mannose-6-phosphate receptor (show IGF2R Antibodies) interaction, suggesting that Chlamydia IncE and cation-independent mannose-6-phosphate receptor (show IGF2R Antibodies) are dependent on the same binding surface on SNX5 (show SNX5 Antibodies).
We conclude that M6PR is an important receptor used by HIV-1 to cross the blood-brain barrier.
Mannose 6-phosphate receptor has a role in acid sphingomyelinase (show SMPD1 Antibodies) deficiency
in hepatocytes of MPR (show PAQR7 Antibodies)-deficient neonatal mice lysosomal storage occurs when both MPRs are lacking, whereas deficiency of CI-MPR (show IGF2R Antibodies) only has no effect on the ultrastructure of the lysosomal system.
Data characterize the retrograde transport of mannose 6-phosphate receptor MPR46 from endosomes to the trans-Golgi network by an in vitro transport assay using mouse fibroblast cell lines.
there is not a an Mpr300- or Mpr46-dependent pathway of granzyme-mediated killing in internalization of monomeric and complexed granzyme B
These results indicate that beta-glucuronidase (show GUSB Antibodies) transport into brain parenchyma in early postnatal life is mediated by the mannose 6-phosphate/insulin-like growth factor II receptor (show IGF2R Antibodies).
Mpr46 is dispensable on target cells for lysis and apoptosis mediated by alloreactive cytotoxic T lymphocytes.
The murine 46-kDa mannose 6-phosphate receptor has the capacity to deliver its cargo proteins to lysosomes even in the absence of endosomal acidification.
epinephrine restores the M6P receptor-mediated functional transport of (131)I-P-beta-glucuronidase (show GUSB Antibodies) across the blood brain barrier in adults to levels seen in the neonate
Rotaviruses reach late endosomes and require M6PR and cathepsin proteases to enter the cell.
Expression and binding properties of mannose-6-phosphate receptors CD-MPR and CI-MPR (show IGF2R Antibodies) differ during perinatal development in rat liver.
Analysis of full-length sequences for MPR 46 from zebrafish (Danio rerio) and its functional analysis.
This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X.
46-kDa mannose 6-phosphate receptor
, CD Man-6-P receptor
, Mr 46,000 Man6PR
, cation-dependent mannose-6-phosphate receptor
, small mannose 6-phosphate receptor
, 46 kDa mannose 6-phosphate receptor
, MPR 46
, mannose-6-phosphate receptor (cation dependent)
, Mannose 6-Phosphate Receptor
, Cation-dependent mannose-6-phosphate receptor
, insulin-like growth factor 2 receptor