anti-Mannose-6-Phosphate Receptor (Cation Dependent) (M6PR) Antibodies

Human Mannose-6-Phosphate Receptor (Cation Dependent) (M6PR) interaction partners

1. Results suggest that, in hormone-responsive breast cancer cells, CD-MPR and cathepsin D are distributed together, and that their expression and distribution are influenced by estradiol. These findings strongly support the involvement of the CD-MPR in the pro-enzyme transport in MCF-7 cells, suggesting the participation of this receptor in the procathepsin D secretion previously reported in breast cancer cells.

2. Most rotavirus strains require the cation-independent mannose-6-phosphate receptor, sortilin-1, and cathepsins to enter cells.

3. In light of existing report suggesting critical role of Nef-GCC185 interaction reveals valuable mechanistic insights affecting specific protein transport pathway in docking of late endosome derived Rab9 bearing transport vesicle at TGN elucidating role of Nef during viral pathogenesis.

4. Results suggest that Rab protein Rab29 is essential for the integrity of the trans-Golgi network (TGN) and participates in the retrograde trafficking of mannose-6-phosphate receptor (M6PR).

5. These data indicate that clathrin is required for the function of AP-1- and GGA-coated carriers at the trans-Golgi network but may be dispensable for outward traffic en route to the plasma membrane.

6. Sortilin is a new alpha-Gal A receptor expressed in renal endothelial cells and that this receptor together with the M6PR is able to internalize circulating alpha-Gal A.

7. Mannose receptor (MR) engagement by mesothelin GPI anchor polarizes tumor-associated macrophages and is blocked by anti-MR human recombinant antibody

8. mediates in vitro human immunodeficiency virus and sperm cell interaction

9. sorting of the CD-MPR in late endosomes requires a distinct di-aromatic motif with only limited possibilities for variations

10. All 5 MPRci-deficient lines resisted infection by cell-free, but not cell-associated, VZV, secreted lysosomal enzymes, and released infectious virions when infected by cell-associated VZV

11. We conclude that the CI-MPR participates in lysosomal and granular targeting of serglycin and basic proteins such as lysozyme associated with the proteoglycan in hematopoietic cells.

12. sortilin and mannose-6-phosphate receptors recycle to the TGN in SNX1-dependent carriers, which we named endosome-to-TGN transport carriers

13. Missorting of cathepsin D in GARP-depleted cells results from accumulation of recycling MPRs in a population of light, small vesicles downstream of endosomes.

14. Data demonstrate that Rab31 is required for transport of mannose 6-phosphate receptors from the trans-Golgi network to endosomes and for the Golgi/TGN organization.

Mouse (Murine) Mannose-6-Phosphate Receptor (Cation Dependent) (M6PR) interaction partners

1. Finally, Chlamydia trachomatis infection interferes with the SNX5:cation-independent mannose-6-phosphate receptor interaction, suggesting that Chlamydia IncE and cation-independent mannose-6-phosphate receptor are dependent on the same binding surface on SNX5.

2. We conclude that M6PR is an important receptor used by HIV-1 to cross the blood-brain barrier.

3. Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice

4. Mannose 6-phosphate receptor has a role in acid sphingomyelinase deficiency

5. in hepatocytes of MPR-deficient neonatal mice lysosomal storage occurs when both MPRs are lacking, whereas deficiency of CI-MPR only has no effect on the ultrastructure of the lysosomal system.

6. Data characterize the retrograde transport of mannose 6-phosphate receptor MPR46 from endosomes to the trans-Golgi network by an in vitro transport assay using mouse fibroblast cell lines.

7. there is not a an Mpr300- or Mpr46-dependent pathway of granzyme-mediated killing in internalization of monomeric and complexed granzyme B

8. These results indicate that beta-glucuronidase transport into brain parenchyma in early postnatal life is mediated by the mannose 6-phosphate/insulin-like growth factor II receptor.

9. Mpr46 is dispensable on target cells for lysis and apoptosis mediated by alloreactive cytotoxic T lymphocytes.

10. The murine 46-kDa mannose 6-phosphate receptor has the capacity to deliver its cargo proteins to lysosomes even in the absence of endosomal acidification.

11. epinephrine restores the M6P receptor-mediated functional transport of (131)I-P-beta-glucuronidase across the blood brain barrier in adults to levels seen in the neonate

12. the alpha-galactosidase enzyme is incorporated via cation-independent mannose 6-phosphate receptors in Schwann cells

Cow (Bovine) Mannose-6-Phosphate Receptor (Cation Dependent) (M6PR) interaction partners

1. Rotaviruses reach late endosomes and require M6PR and cathepsin proteases to enter the cell.

2. Expression and binding properties of mannose-6-phosphate receptors CD-MPR and CI-MPR differ during perinatal development in rat liver.

Zebrafish Mannose-6-Phosphate Receptor (Cation Dependent) (M6PR) interaction partners

1. Analysis of full-length sequences for MPR 46 from zebrafish (Danio rerio) and its functional analysis.

2. The expression patterns suggest time- and tissue-specific functions for the M6P receptors, with particular evidence for roles in neural development.

Rhesus Monkey Mannose-6-Phosphate Receptor (Cation Dependent) (M6PR) interaction partners

1. Rotaviruses reach late endosomes and require M6PR and cathepsin proteases to enter the cell.