anti-Mannose-6-Phosphate Receptor (Cation Dependent) (M6PR) Antibodies

M6PR encodes a member of the P-type lectin family. Additionally we are shipping M6PR Kits (11) and M6PR Proteins (11) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
M6PR 4074 P20645
M6PR 17113 P24668
M6PR 312689 Q6AY20
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Top anti-M6PR Antibodies at antibodies-online.com

Showing 10 out of 72 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-M6PR Antibody Titration: 5.0ug/ml Positive Control: Jurkat cell lysate Human, Mouse 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated FACS, IF, WB M6PR Antibody (C-term) (ABIN650726) western blot analysis in A549 cell line lysates (35 µg/lane).This demonstrates the M6PR antibody detected the M6PR protein (arrow). M6PR Antibody (C-term) (ABIN650726) flow cytometric analysis of A549 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated EIA, IHC (p) 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of M6PR Antibody (N-term)(ABIN389291) in mouse brain tissue lysates (35 µg/lane). M6PR (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human testis tissue reacted with M6PR antibody (N-term) (ABIN389291), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated IHC, WB IHC-P on paraffin sections of human liver.HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module.Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions.Primary antibody: dilution 1: 1000, incubated 30 min at RT (using Autostainer).Sections were counterstained with Harris Hematoxylin. IHC-P on paraffin sections of human liver.HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module.Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm.Detection was done using Novolink HRP polymer from Leica following manufacturers instructions.Primary antibody: dilution 1: 1000, incubated 30 min at RT (using Autostainer).Sections were counterstained with Harris Hematoxylin. 100 μL Log in to see 7 to 8 Days
$454.67
Details
Dog Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
$493.17
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 6 to 7 Days
$242.88
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of Mouse kidney cell line, using M6PR antibody. Immunohistochemistry of paraffin-embedded human liver injury using M6PR antibody at dilution of 1:100 (x40 lens). 100 μL Log in to see 16 Days
$334.02
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of mouse kidney, using M6PR antibody (ABIN5975018) at 1/1000 dilution. Immunohistochemistry of paraffin-embedded human liver injury using M6PR antibody (ABIN5975018) at dilution of 1/100 (40x lens). 100 μL Log in to see 11 to 16 Days
$426.40
Details
Bat Goat Un-conjugated ELISA   100 μg Log in to see 7 to 9 Days
$507.83
Details

M6PR Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-M6PR Antibodies

  1. Human Polyclonal M6PR Primary Antibody for ELISA, WB - ABIN561704 : Steffan, Williams, Welbourne, Cardelli: HGF-induced invasion by prostate tumor cells requires anterograde lysosome trafficking and activity of Na+-H+ exchangers. in Journal of cell science 2010 (PubMed)
    Show all 2 Pubmed References

  2. Cow (Bovine) Polyclonal M6PR Primary Antibody for ELISA - ABIN408673 : Frei, Jeon, Kilcher, Moest, Henning, Jost, Plückthun, Mercer, Aebersold, Carreira, Wollscheid: Direct identification of ligand-receptor interactions on living cells and tissues. in Nature biotechnology 2012 (PubMed)
    Show all 2 Pubmed References

More Antibodies against M6PR Interaction Partners

Human Mannose-6-Phosphate Receptor (Cation Dependent) (M6PR) interaction partners

  1. In light of existing report suggesting critical role of Nef-GCC185 (show GCC2 Antibodies) interaction reveals valuable mechanistic insights affecting specific protein transport pathway in docking of late endosome derived Rab9 (show RAB9A Antibodies) bearing transport vesicle at TGN (show TG Antibodies) elucidating role of Nef during viral pathogenesis.

  2. Results suggest that Rab (show HRB Antibodies) protein Rab29 (show RAB7L1 Antibodies) is essential for the integrity of the trans-Golgi network (TGN (show TG Antibodies)) and participates in the retrograde trafficking of mannose-6-phosphate receptor (M6PR).

  3. These data indicate that clathrin is required for the function of AP-1 (show FOSB Antibodies)- and GGA-coated carriers at the trans-Golgi network but may be dispensable for outward traffic en route to the plasma membrane.

  4. Sortilin (show SORT1 Antibodies) is a new alpha-Gal A receptor expressed in renal endothelial cells and that this receptor together with the M6PR (show IGF2R Antibodies) is able to internalize circulating alpha-Gal A.

  5. Mannose receptor (MR) engagement by mesothelin (show MSLN Antibodies) GPI (show GNPDA1 Antibodies) anchor polarizes tumor-associated macrophages and is blocked by anti-MR human recombinant antibody

  6. sorting of the CD-MPR in late endosomes requires a distinct di-aromatic motif with only limited possibilities for variations

  7. We conclude that the CI-MPR (show IGF2R Antibodies) participates in lysosomal and granular targeting of serglycin (show SRGN Antibodies) and basic proteins such as lysozyme (show LYZ Antibodies) associated with the proteoglycan (show Vcan Antibodies) in hematopoietic cells.

  8. sortilin (show SORT1 Antibodies) and mannose-6-phosphate receptors recycle to the TGN (show TG Antibodies) in SNX1 (show SNX1 Antibodies)-dependent carriers, which we named endosome-to-TGN (show TG Antibodies) transport carriers

  9. Missorting of cathepsin D (show CTSD Antibodies) in GARP (show CNGB1 Antibodies)-depleted cells results from accumulation of recycling MPRs in a population of light, small vesicles downstream of endosomes.

  10. Data demonstrate that Rab31 (show RAB31 Antibodies) is required for transport of mannose 6-phosphate receptors from the trans-Golgi network to endosomes and for the Golgi/TGN (show TG Antibodies) organization.

Mouse (Murine) Mannose-6-Phosphate Receptor (Cation Dependent) (M6PR) interaction partners

  1. Finally, Chlamydia trachomatis infection interferes with the SNX5 (show SNX5 Antibodies):cation-independent mannose-6-phosphate receptor (show IGF2R Antibodies) interaction, suggesting that Chlamydia IncE and cation-independent mannose-6-phosphate receptor (show IGF2R Antibodies) are dependent on the same binding surface on SNX5 (show SNX5 Antibodies).

  2. We conclude that M6PR is an important receptor used by HIV-1 to cross the blood-brain barrier.

  3. Mannose 6-phosphate receptor has a role in acid sphingomyelinase (show SMPD1 Antibodies) deficiency

  4. in hepatocytes of MPR (show PAQR7 Antibodies)-deficient neonatal mice lysosomal storage occurs when both MPRs are lacking, whereas deficiency of CI-MPR (show IGF2R Antibodies) only has no effect on the ultrastructure of the lysosomal system.

  5. Data characterize the retrograde transport of mannose 6-phosphate receptor MPR46 from endosomes to the trans-Golgi network by an in vitro transport assay using mouse fibroblast cell lines.

  6. there is not a an Mpr300- or Mpr46-dependent pathway of granzyme-mediated killing in internalization of monomeric and complexed granzyme B

  7. These results indicate that beta-glucuronidase (show GUSB Antibodies) transport into brain parenchyma in early postnatal life is mediated by the mannose 6-phosphate/insulin-like growth factor II receptor (show IGF2R Antibodies).

  8. Mpr46 is dispensable on target cells for lysis and apoptosis mediated by alloreactive cytotoxic T lymphocytes.

  9. The murine 46-kDa mannose 6-phosphate receptor has the capacity to deliver its cargo proteins to lysosomes even in the absence of endosomal acidification.

  10. epinephrine restores the M6P receptor-mediated functional transport of (131)I-P-beta-glucuronidase (show GUSB Antibodies) across the blood brain barrier in adults to levels seen in the neonate

Cow (Bovine) Mannose-6-Phosphate Receptor (Cation Dependent) (M6PR) interaction partners

  1. Rotaviruses reach late endosomes and require M6PR and cathepsin proteases to enter the cell.

  2. Expression and binding properties of mannose-6-phosphate receptors CD-MPR and CI-MPR (show IGF2R Antibodies) differ during perinatal development in rat liver.

Zebrafish Mannose-6-Phosphate Receptor (Cation Dependent) (M6PR) interaction partners

  1. Analysis of full-length sequences for MPR 46 from zebrafish (Danio rerio) and its functional analysis.

Rhesus Monkey Mannose-6-Phosphate Receptor (Cation Dependent) (M6PR) interaction partners

  1. Rotaviruses reach late endosomes and require M6PR and cathepsin proteases to enter the cell.

M6PR Antigen Profile

Protein Summary

This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X.

Gene names and symbols associated with M6PR

  • mannose-6-phosphate receptor, cation dependent (M6PR) antibody
  • mannose-6-phosphate receptor, cation dependent (M6pr) antibody
  • mannose-6-phosphate receptor (cation dependent) L homeolog (m6pr.L) antibody
  • mannose-6-phosphate receptor (cation dependent) (m6pr) antibody
  • mannose-6-phosphate receptor (cation dependent) S homeolog (m6pr.S) antibody
  • mannose-6-phosphate receptor (cation dependent) (Ethha_1678) antibody
  • Cation-dependent mannose-6-phosphate receptor (mprd) antibody
  • CD-MPR antibody
  • CDMPR antibody
  • M6PR antibody
  • MGC68896 antibody
  • MGC89423 antibody
  • MGC130765 antibody
  • MPR-46 antibody
  • MPR 46 antibody
  • Mpr46 antibody
  • mprd antibody
  • SMPR antibody
  • wu:fj81h11 antibody
  • zgc:77757 antibody

Protein level used designations for M6PR

46-kDa mannose 6-phosphate receptor , CD Man-6-P receptor , Mr 46,000 Man6PR , cation-dependent mannose-6-phosphate receptor , small mannose 6-phosphate receptor , 46 kDa mannose 6-phosphate receptor , MPR 46 , CD-MPR , mannose-6-phosphate receptor (cation dependent) , Mannose 6-Phosphate Receptor , Cation-dependent mannose-6-phosphate receptor , insulin-like growth factor 2 receptor

GENE ID SPECIES
4074 Homo sapiens
17113 Mus musculus
281291 Bos taurus
312689 Rattus norvegicus
380564 Xenopus laevis
396044 Gallus gallus
406486 Danio rerio
477700 Canis lupus familiaris
493477 Xenopus (Silurana) tropicalis
496207 Xenopus laevis
716696 Macaca mulatta
736013 Pan troglodytes
10092655 Ethanoligenens harbinense YUAN-3
100194796 Salmo salar
100726206 Cavia porcellus
100154117 Sus scrofa
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