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MAPK8IP1 encodes a regulator of the pancreatic beta-cell function. Additionally we are shipping MAPK8IP1 Proteins (4) and and many more products for this protein.
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These interactions are required for SRC (show SRC Antibodies)-induced activation of VAV (show VAV1 Antibodies) and the subsequent engagement of a JIP1-tethered JNK (show MAPK8 Antibodies) signaling module.
Phosphorylation of KLC1 (show KLC1 Antibodies) at Thr466 increased in aged brains, and JIP1 binding to kinesin-1 decreased, suggesting that APP (show APP Antibodies) transport is impaired by aging. Authors conclude that phosphorylation of KLC1 (show KLC1 Antibodies) at Thr466 regulates the velocity of transport of APP (show APP Antibodies) by kinesin-1 by modulating its interaction with JIP1b.
It mediates Alzheimer-disease like pathologies in AICD-Tg mice and that JNK (show MAPK8 Antibodies) signaling may contribute to amyloid-independent mechanisms of AD pathogenesis.
Enhanced fast-velocity and efficient high-frequency APP (show APP Antibodies) anterograde transport observed in neurons are mediated by novel roles of JIP1b.
a simple yet modular mechanism for JIP1 scaffold assembly in mammals
There is a collaborative relationship between JIP1 and AKT (show AKT1 Antibodies) that is required for axon growth and can be regulated by changes in neuronal activity.
identify plenty of SH3 (POSH (show SH3RF1 Antibodies)) and JNK-interacting protein 1 (JIP-1) as a multiprotein scaffold network for TCR-mediated JNK1 (show MAPK8 Antibodies) activation in CD8 (show CD8A Antibodies)(+) T cells.
The phosphorylation of S421 of JIP1 serves as a molecular switch to regulate the direction of APP (show APP Antibodies) transport in neurons.
Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 (show MAP3K11 Antibodies) interaction with JIP1 scaffold protein (show HOMER1 Antibodies) in cytokine-induced pancreatic beta cell death
JIP1 forms a trimetric complex with RBP-Jk (show RBPJ Antibodies) and Notch1 (show NOTCH1 Antibodies)-IC, prevents physical association between Notch1 (show NOTCH1 Antibodies)-IC and RBP-Jk (show RBPJ Antibodies), sequesters RBP-JK (show RBPJ Antibodies) in the cytoplasm, and suppresses the Notch1 (show NOTCH1 Antibodies) signaling pathway.
All binary complexes (KLC1 (show KLC1 Antibodies):APP (show APP Antibodies), KLC1 (show KLC1 Antibodies):JIP1, and APP:JIP1) contain conformations with favorable binding free energies indicating that KLC1 (show KLC1 Antibodies) and JIP1 may take part in APP (show APP Antibodies) transport in Alzheimer's disease patients.
analysis of the role of JIP1 in APP (show APP Antibodies) transport; knockdown of JIP1 did not affect either amyloid precursor protein (show APP Antibodies) transport or amyloid-beta peptide production
Data show that small GTPase (show RACGAP1 Antibodies) RALA (show rala Antibodies) regulates formation of a JIP1 (C-Jun (show JUN Antibodies)-amino-terminal-interacting protein 1) scaffold complex to propagate JNK (show MAPK8 Antibodies) signaling toward FOXO4 (show FOXO4 Antibodies) (forkhead box O (show FOXO Antibodies) transcription factor) in response to reactive oxygen species (ROS (show ROS1 Antibodies)).
In resected pancreatic cancer, carriers of a minor allele for rs3824872 (MAPK8IP1) were associated with a survival advantage compared with noncarriers with an additional 2-year survival if both minor alleles were present.
Data suggest that caspase 3 (show CASP3 Antibodies)-mediated cleavage of JIP1 scaffold proteins may represent an important mechanism for modulation of JNK (show MAPK8 Antibodies) signalling during apoptotic cell death.
Data show that mechanical stress of urothelial cells activates in vivo JNK (show MAPK8 Antibodies), as a consequence of a regulated expression of IB1/JIP-1, and that urothelial connexin 26 (show GJB2 Antibodies) may be directly regulated by the AP-1 (show FOSB Antibodies) complex.
results suggest that JIP (show SMAD4 Antibodies)-1b may function as a protein linking the kinesin-I motor protein to the cargo receptor, APP (show APP Antibodies), and that the JNK (show MAPK8 Antibodies) signaling pathway may regulate the phosphorylation of this cargo protein through the JIP (show SMAD4 Antibodies)-1b scaffold
JIP1 may act as an Akt1 (show AKT1 Antibodies) scaffold, which regulates the enzymatic activity of Akt1 (show AKT1 Antibodies) and can exert signaling effects independent of JNK (show MAPK8 Antibodies) activity
JIP-1 protein may regulate kinesin-I-dependent neuronal AbetaPP transport, which controls AbetaPP processing
This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.
mitogen-activated protein kinase 8 interacting protein 1
, c-Jun-amino-terminal kinase-interacting protein 1-like
, C-Jun-amino-terminal kinase-interacting protein 1
, JNK MAP kinase scaffold protein 1
, JNK-interacting protein 1
, mitogen activated protein kinase 8 interacting protein 1
, mitogen-activated protein kinase 8-interacting protein 1
, protein kinase, mitogen-activated 8 interacting protein
, JIP-1-related protein
, mitogen activated protein kinase 8 interacting protein
, PRKM8 interacting protein
, islet-brain 1
, islet brain 1