anti-Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) Antibodies

MAPK8IP1 encodes a regulator of the pancreatic beta-cell function. Additionally we are shipping MAPK8IP1 Proteins (4) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MAPK8IP1 19099 Q9WVI9
MAPK8IP1 116457 Q9R237
MAPK8IP1 9479 Q9UQF2
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-MAPK8IP1 Antibodies at antibodies-online.com

Showing 10 out of 87 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of JIP1 Antibody (C-term) (ABIN652961) in MCF-7 cell line lysates (35 µg/lane). JIP1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with JIP1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of JIP-1 in Jurkat cell lysate (Lane 1) mouse intestine (Lane 2) and rat kidney (Lane 3) tissue lysates. 100 μg Log in to see 2 to 3 Days
$245.00
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from COLO205 cells, treated with Serum 20% 15', using JIP1 (Ab-103) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using JIP1 (Ab-103) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from COLO205 cells treated with Serum 20% 15', using JIP1 (Phospho-Thr103) Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of NIH-3T3 cells, using JIP1 (Phospho-Thr103) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, WB 100 μL Log in to see 16 Days
$181.73
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, WB Western Blot (WB) analysis of specific cells using JIP-1 Polyclonal Antibody. 100 μL Log in to see 16 Days
$181.73
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB Western blot analysis of Phospho-JIP1 (Thr103) using K562 whole cell lysates ABIN6278654 staining  COLO205 cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated IHC (p), WB WB Image Sample(30 ug whole cell lysate) A:Hep G2 , 7.5% SDS PAGE antibody diluted at 1:1000 IHC-P Image JIP1 antibody detects JIP1 protein at cytoplasm on mouse brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse brain. JIP1 antibody , diluted at 1:500. 100 μL Log in to see 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated WB Western blot analysis of extract of various cells, using MAPK8IP1 antibody. 100 μL Log in to see 16 Days
$366.77
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Anti-MAPK8IP1 Polyclonal Antibody, Unconjugated (ABIN716441) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$317.90
Details

More Antibodies against MAPK8IP1 Interaction Partners

Mouse (Murine) Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) interaction partners

  1. These interactions are required for SRC-induced activation of VAV and the subsequent engagement of a JIP1-tethered JNK signaling module.

  2. Phosphorylation of KLC1 at Thr466 increased in aged brains, and JIP1 binding to kinesin-1 decreased, suggesting that APP transport is impaired by aging. Authors conclude that phosphorylation of KLC1 at Thr466 regulates the velocity of transport of APP by kinesin-1 by modulating its interaction with JIP1b.

  3. It mediates Alzheimer-disease like pathologies in AICD-Tg mice and that JNK signaling may contribute to amyloid-independent mechanisms of AD pathogenesis.

  4. Enhanced fast-velocity and efficient high-frequency APP anterograde transport observed in neurons are mediated by novel roles of JIP1b.

  5. a simple yet modular mechanism for JIP1 scaffold assembly in mammals

  6. There is a collaborative relationship between JIP1 and AKT that is required for axon growth and can be regulated by changes in neuronal activity.

  7. identify plenty of SH3 (POSH) and JNK-interacting protein 1 (JIP-1) as a multiprotein scaffold network for TCR-mediated JNK1 activation in CD8(+) T cells.

  8. The phosphorylation of S421 of JIP1 serves as a molecular switch to regulate the direction of APP transport in neurons.

  9. Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic beta cell death

  10. JIP1 forms a trimetric complex with RBP-Jk and Notch1-IC, prevents physical association between Notch1-IC and RBP-Jk, sequesters RBP-JK in the cytoplasm, and suppresses the Notch1 signaling pathway.

  11. Data suggest that JIP1-mediated JNK activation plays a critical role in metabolic stress regulation of the JNK signaling pathway.

  12. JIP1b can directly modulate APP metabolism by interacting with the APP cytoplasmic domain, independent of its regulation of the JNK signaling cascade.

  13. JIP-1 targets MKP-7 to dephosphorylate JNK.

  14. The transient focal ischemic insult produced by middle cerebral artery occlusion (MCAO) strongly activated JNK in brain of jip1(+/+), jip1(+/-), and jip1(-/-) mice.

  15. signaling network organized commonly by JIP1 and JSAP1 regulates the axon guidance in the developing brain.

  16. the phosphorylation of APP regulates the formation of a pAPP-JIP-1 complex that accumulates in neurites independent of nonphosphorylated APP

  17. POSH and JIPs directly associate with one another to form a multiprotein complex, PJAC (POSH-JIP apoptotic complex), that includes all of the known kinase components of the pathway.

  18. IB1/JIP-1 monomers and dimers may differ in compartmental localization and thus function as a scaffold protein of the JNK signaling cascade in the cytoplasm or as a transcription factor in nuclei.

  19. JIP scaffold proteins are critically required for normal NMDA receptor function.

  20. This study shows that before primary cortical neurons become polarized, JIP1 specifically localizes to a single neurite and that after axonal specification,it accumulates in the emerging axon.

Human Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) interaction partners

  1. All binary complexes (KLC1:APP, KLC1:JIP1, and APP:JIP1) contain conformations with favorable binding free energies indicating that KLC1 and JIP1 may take part in APP transport in Alzheimer's disease patients.

  2. analysis of the role of JIP1 in APP transport; knockdown of JIP1 did not affect either amyloid precursor protein transport or amyloid-beta peptide production

  3. Data show that small GTPase RALA regulates formation of a JIP1 (C-Jun-amino-terminal-interacting protein 1) scaffold complex to propagate JNK signaling toward FOXO4 (forkhead box O transcription factor) in response to reactive oxygen species (ROS).

  4. In resected pancreatic cancer, carriers of a minor allele for rs3824872 (MAPK8IP1) were associated with a survival advantage compared with noncarriers with an additional 2-year survival if both minor alleles were present.

  5. Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic beta cell death

  6. Data suggest that caspase 3-mediated cleavage of JIP1 scaffold proteins may represent an important mechanism for modulation of JNK signalling during apoptotic cell death.

  7. Data show that mechanical stress of urothelial cells activates in vivo JNK, as a consequence of a regulated expression of IB1/JIP-1, and that urothelial connexin 26 may be directly regulated by the AP-1 complex.

  8. role in promoting transcription of amyloid beta protein precursor

  9. results suggest that JIP-1b may function as a protein linking the kinesin-I motor protein to the cargo receptor, APP, and that the JNK signaling pathway may regulate the phosphorylation of this cargo protein through the JIP-1b scaffold

  10. Promoter variant is associated with Alzheimer's disease.

  11. JIP1 may act as an Akt1 scaffold, which regulates the enzymatic activity of Akt1 and can exert signaling effects independent of JNK activity

  12. JIP-1 protein may regulate kinesin-I-dependent neuronal AbetaPP transport, which controls AbetaPP processing

  13. JIP-1 only facilitated (but is not required for) phosphorylation of Amyloid beta protein precursor but not of the two other family members APLP1 (amyloid precursor-like protein 1) and APLP2

  14. stability is modulated by intracellular calcium

  15. Growth control of prostate cancer cells can be mediated through JNK/c-Jun pathway, but androgen responsiveness can be independent of this pathway; androgen independence in progressive prostate cancer may not occur through activation of this pathway.

  16. High IGF II expression was followed by high expression of JIP-1 in testicular neoplasms.

  17. IB1/JIP-1 participates to the neuronal phenotype of the human LNCaP cells and is a regulator of JNK signaling pathway

  18. JIP1 and JIP3, have a cross-talk that leads to the regulation of the ASK1-SEK1-JNK signal during glucose deprivation; cross-talk between JIP3 and JIP1 is mediated through SEK1-JNK2 and Akt1.

  19. Altogether, our data demonstrate that Akt1 participates in a negative regulatory feedback loop by interacting with the JIP1 scaffold protein.

  20. the phosphorylation of APP regulates the formation of a pAPP-JIP-1 complex that accumulates in neurites independent of nonphosphorylated APP

MAPK8IP1 Antigen Profile

Protein Summary

This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.

Gene names and symbols associated with MAPK8IP1

  • mitogen-activated protein kinase 8 interacting protein 1 (MAPK8IP1) antibody
  • mitogen-activated protein kinase 8 interacting protein 1 (Mapk8ip1) antibody
  • IB1 antibody
  • Jip-1 antibody
  • JIP1 antibody
  • Mapk8ip antibody
  • mjip-2a antibody
  • PRKM8IP antibody
  • Skip antibody

Protein level used designations for MAPK8IP1

mitogen-activated protein kinase 8 interacting protein 1 , c-Jun-amino-terminal kinase-interacting protein 1-like , C-Jun-amino-terminal kinase-interacting protein 1 , IB-1 , JNK MAP kinase scaffold protein 1 , JNK-interacting protein 1 , islet-brain-1 , mitogen activated protein kinase 8 interacting protein 1 , mitogen-activated protein kinase 8-interacting protein 1 , protein kinase, mitogen-activated 8 interacting protein , JIP-1-related protein , JRP , mitogen activated protein kinase 8 interacting protein , PRKM8 interacting protein , islet-brain 1 , islet brain 1

GENE ID SPECIES
423202 Gallus gallus
100344706 Oryctolagus cuniculus
100473891 Ailuropoda melanoleuca
19099 Mus musculus
116457 Rattus norvegicus
9479 Homo sapiens
483640 Canis lupus familiaris
524806 Bos taurus
Selected quality suppliers for anti-MAPK8IP1 (MAPK8IP1) Antibodies
Did you look for something else?