Natural Cytotoxicity Triggering Receptor 2 Proteins (NCR2)

Human Natural Cytotoxicity Triggering Receptor 2 (NCR2) interaction partners

1. Study identified a novel ligand for NKp44 on astrocytes. Expression of this novel ligand decreased with increasing HIV-3S peptide concentration and blocking this novel ligand decreased NK cell killing. NK cell killing of astrocytes was decreased when astrocytes were incubated with HIV-3S peptide. NKp44 has a protective effect on astrocytes from NK cell mediated killing during HIV infection and impact astrocyte's role.

2. NKp44 and NKp30 (show NCR3 Proteins) splice variants profiles are tissue/condition specific and demonstrate similarity between placenta and cancerous tissues.

3. NKp44-1 expression was significantly associated with poor survival of AML (show RUNX1 Proteins) patients. Moreover, activation of PBMC from healthy controls showed co-dominant expression of NKp44-1 and NKp44-3, while primary NK clones show more diverse NKp44 splice variant profiles.

4. On CD56 (show NCAM1 Proteins)(+) CD3 (show CD3 Proteins)(-) cells, NKp44 and NKp46 (show NCR1 Proteins) expressions were high in the acute hepatitis E patients, whereas NKp30 (show NCR3 Proteins), NKp44, NKp46 (show NCR1 Proteins) and NKG2D (show KLRK1 Proteins) were high in the recovered individuals.

5. demonstrated that the mitogen and iK562 exposure to peripheral blood mononuclear cells can significantly improve NK activity which is co-related to the higher expression of NKp44 and NKG2D (show KLRK1 Proteins)

6. NCR(+) ILC3 from skin and blood of psoriasis patients produced IL-22 (show IL22 Proteins), which is regarded as a key driver of epidermal thickening, suggesting that NCR(+) ILC3 may participate in psoriasis pathology.

7. Balance between activating NKG2D (show KLRK1 Proteins), DNAM-1 (show CD226 Proteins), NKp44 and NKp46 (show NCR1 Proteins) and inhibitory CD94 (show KLRD1 Proteins)/NKG2A (show KLRC1 Proteins) receptors determine natural killer degranulation towards rheumatoid arthritis synovial fibroblasts.

8. NKp44+ ILC3 are expressed in human skin and blood and may have a role in psoriasis pathogenesis

9. Expression of NKp44 ligand by normal articular chondrocytes is not involved in their killing by unstimulated NK cells; however, it is responsible for anti-chondrocyte cytotoxicity mediated by long-term activated NK cells.

10. MLL5 is a cellular ligand for the natural cytotoxicity receptor NKp44.