NKp44/NCR2 Protein (AA 1-190) (His tag)

Catalog No. ABIN7505570

Product Details

Target: NKp44/NCR2 (NCR2) (Natural Cytotoxicity Triggering Receptor 2 (NCR2))

Protein Type: Recombinant

Protein Characteristics: AA 1-190

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This NKp44/NCR2 protein is labelled with His tag.

Sequence: Met 1-Pro 190

Characteristics: A DNA sequence encoding the human NCR2 (NP_004819.2) extracellular domain (Met 1-Pro 190) was fused with a polyhistidine tag at the C-terminus.

Purity: >88 % as determined by reducing SDS-PAGE.

Endotoxin Level: <1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 12 months

Target Details

Target: NKp44/NCR2 (NCR2) (Natural Cytotoxicity Triggering Receptor 2 (NCR2))

Alternative Name: NCR2 (NCR2 Products)

Synonyms: CD336 Protein, LY95 Protein, NK-p44 Protein, NKP44 Protein, dJ149M18.1 Protein, uncharacterized LOC609023 Protein, natural cytotoxicity triggering receptor 2 Protein, LOC609023 Protein, NCR2 Protein

Background:

Background: Natural cytotoxicity triggering receptor 2 (NCR2), also known as Natural killer cell p44-related protein (NKp44), or CD336, is a member of the natural cytotoxicity receptor (NCR) family, which composed of one Ig-like extracellular domain, a transmembrane segment, and a cytoplasmic domain. It is a novel transmembrane glycoprotein belonging to the Immunoglobulin superfamily characterized by a single extracellular V-type domain. The cytoplasmic domain of NKp44 also contains a sequence that matches the immunoreceptor tyrosine-based inhibitory motif (ITIM) consensus. This Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. NKp44 is selectively expressed by IL-2-activated NK cells and may contribute to the increased efficiency of activated NK cells to mediate tumor cell lysis. Tumor cell recognition of the mutated NKp44 proteins was significantly reduced and correlated with their lower recognition of heparin.

Synonym: CD336,dJ149M18.1,LY95,NK-p44,NKP44,RP1-149M18.2

Molecular Weight: 20 kDa

UniProt: O95944