anti-Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 (KCNC1) Antibodies

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Additionally we are shipping Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KCNC1 16502 P15388
KCNC1 25327 P25122
KCNC1 3746 P48547
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Top anti-Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 Antibodies at antibodies-online.com

Showing 10 out of 160 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-KCNC1 Antibody Titration:  2.5ug/ml  Positive Control:  HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$249.00
Details
Mouse Rabbit Un-conjugated DB, IHC (fro), IF, WB 0.1 mL Log in to see 6 to 8 Days
$412.50
Details
Rat Rabbit Un-conjugated IHC (fro) 10 blots Log in to see 6 to 8 Days
$511.50
Details
Cow Rabbit Un-conjugated WB Western blot analysis of Kv3.1 expression in HepG2 (A), rat brain (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IHC (p), WB KCNC1 Antibody (C-term) (ABIN658466) western blot analysis in HepG2 cell line lysates (35 µg/lane). This demonstrates the KCNC1 antibody detected the KCNC1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Mouse Rabbit Un-conjugated IHC (fro), IHC, WB 0.1 mL Log in to see 7 to 9 Days
$446.35
Details
Rat Rabbit Un-conjugated IHC, WB IHC staining of medial nucleus of the trapezoid body (MNTB) cells with the phospho-Ser503  Kv3.1 subunit antibody. The left panel shows control cells. The right panel shows cells that have been exposed to the protein kinase C activator PMA. IHC staining of medial nucleus of the trapezoid body (MNTB) cells with the phospho-Ser503  Kv3.1 subunit antibody. The left panel shows control cells. The right panel shows cells that have been exposed to the protein kinase C activator PMA. 100 μL Log in to see 3 to 4 Days
$508.20
Details
Cow Rabbit Un-conjugated BP, IP, Neut, WB 0.1 mL Log in to see 7 to 9 Days
$418.10
Details
Human Mouse Un-conjugated AA, ICC, IF, IHC, WB 100 μg Log in to see 3 to 4 Days
$453.70
Details
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry: Potassium Channel Kv3.1 Antibody [NBP2-30395] - Immunohistochemical staining of human cerebellum shows strong positivity. Immunocytochemistry/Immunofluorescence: Potassium Channel Kv3.1 Antibody  - Staining of human cell line U-2 OS shows localization to nucleus, nuclear membrane & cytosol. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details

Top referenced anti-Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 Antibodies

  1. Mouse (Murine) Polyclonal KCNC1 Primary Antibody for IHC (fro), IHC - ABIN152620 : Burger, Ribera: Xenopus spinal neurons express Kv2 potassium channel transcripts during embryonic development. in The Journal of neuroscience : the official journal of the Society for Neuroscience 1996 (PubMed)
    Show all 6 Pubmed References

  2. Cow (Bovine) Polyclonal KCNC1 Primary Antibody for BP, IP - ABIN452090 : Chen, Wang, Rong, Wang, Wang: Effects of fluoxetine on protein expression of potassium ion channels in the brain of chronic mild stress rats. in Acta pharmaceutica Sinica. B 2015 (PubMed)
    Show all 2 Pubmed References

  3. Mouse (Murine) Polyclonal KCNC1 Primary Antibody for IHC (fro), IF - ABIN550213 : Pongs: Voltage-gated potassium channels: from hyperexcitability to excitement. in FEBS letters 1999 (PubMed)
    Show all 3 Pubmed References

  4. Human Polyclonal KCNC1 Primary Antibody for WB - ABIN538246 : Rettig, Wunder, Stocker, Lichtinghagen, Mastiaux, Beckh, Kues, Pedarzani, Schröter, Ruppersberg: Characterization of a Shaw-related potassium channel family in rat brain. in The EMBO journal 1992 (PubMed)
    Show all 3 Pubmed References

  5. Mouse (Murine) Polyclonal KCNC1 Primary Antibody for DB, IHC (fro) - ABIN372706 : Ezzeddine, Glanzman: Prolonged habituation of the gill-withdrawal reflex in Aplysia depends on protein synthesis, protein phosphatase activity, and postsynaptic glutamate receptors. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2003 (PubMed)
    Show all 8 Pubmed References

More Antibodies against Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 Interaction Partners

Mouse (Murine) Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 (KCNC1) interaction partners

  1. Kv3.1 channels stimulate adult neural precursor cell proliferation and neuronal differentiation.

  2. The resting (closed) Kv3.1 channel conformation forms the high-affinity state for gambierol.

  3. high-affinity multimeric binding between the Kv3.1 T1 domain and KIF5B requires three basic residues in the KIF5B tail. Kv3.1 T1 competes with the motor domain and microtubules, but not with kinesin light chain 1 (KLC1), for binding to the KIF5B tail.

  4. Although all Kv3 transcripts were significantly expressed at embryonic age in whole brain extracts, only Kv3.1, Kv3.2 and Kv3.4 subunit proteins were present, suggesting a novel role for Kv3 channels at this developmental stage.

  5. Block of Kv3.1 channels hinders spike repolarization and severely depresses evoked fast firing in deep cerebellar nuclear neurons.

  6. Mice lacking both Kcnc1 and Kcnc2 genes fail to express the Kv3.1 and Kv3.2 channels in in the suprachiasmatic nucleus.

  7. These results provide evidence that acoustically driven auditory activity can selectively regulate high-threshold potassium currents in the MNTB of normal hearing mice, likely due to an increased membrane expression of Kv3.1b channels.

  8. As Kcnc1, but not Kcnc3, alleles are lost, mutant mice exhibit increasing gait ataxia accompanied by spike broadening and deceleration in deep cerebellar nuclei. neurons.

  9. interaction with CALP/KCHIP4

  10. NCS-1 is an accessory subunit of Kv4-encoded I(to,f) channels that functions to regulate I(to,f) density in the mammalian myocardium.

  11. Kv4.3, in association with K(+) channel-interacting proteins, is the major molecular determinant of A-type potassium current in murine colonic myocytes.

  12. Modulation of the kv3.1b potassium channel isoform adjusts the fidelity of the firing pattern of auditory neurons.

  13. Motor deficits and altered synaptic transmission at the parallel fiber-Purkinje cell synapse in Kv3.1 knockout mice.

  14. Ongoing activity in auditory brainstem neurons is necessary for the maintenance of Kv3.1 tonotopicity through the CREB pathway

  15. Double mutant Kv3.1/Kv3.3-deficient mice are constitutively hyperactive. Increased ambulatory and stereotypic activity in conjunction with sleep loss was seen in Kv3.1-single mutants but not in Kv3.3-single mutants.

  16. Starburst amacrine cells have large outward currents which are mediated in part by the Kv3.1 channel.

  17. all Renshaw cells expressed Kv3.1b weakly from postnatal day 14, and strongly at postnatal day 21.

  18. two voltage-gated potassium channels, Kv3.1 and Kv3.3, control sleep in wild-type and Kv3-mutant mice

  19. Calcineurin and NFATc3 constitute a Ca(2+)-driven signaling module that contributes to the nonuniform distribution of Kv4 expression, and hence Ito function, in the mouse left ventricle.

  20. K(V)3.1 K(+) current accounts for significant component of total K(+) current in oligodendrocyte lineage and, in association with OSP/claudin-11, plays significant role in OPC proliferation and migration and myelination of axons.

Human Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 (KCNC1) interaction partners

  1. A recurrent de novo mutation in KCNC1 (c.959G>A, p.Arg320His) has been identified recently as one of the important genetic causes of progress myoclonic epilepsy. This recurrent mutation in KCNC1 was identified in the two brothers who showed characteristic features of myoclonus epilepsy and ataxia due to potassium channel mutation (MEAK). The asymptomatic mother was suspected as being mosaic for this mutation.

  2. KNCN1 p.R320H mutation causes MEAK syndrome.

  3. A nonsense variant in KCNC1 gene was identified in three family members with intellectual disability without seizures.

  4. reviews the phenotype/genotype of progressive myoclonus epilepsy and ataxia due to potassium channel mutation (MEAK)associated with KCNC1 mutations [review]

  5. KCNC1 produces a resurgent current during repolarization, ensuring enough repolarizing power to terminate each action potential. The current results from a combination of steep voltage-dependent gating kinetics and ultra-fast voltage-sensor relaxation.

  6. A recurrent KCNC1 de novo mutation, c.959G>A (p.Arg320His), is a new major cause for progressive myoclonus epilepsy. It has a dominant-negative loss-of-function effect.

  7. Findings show a decrease in Kv3.1b channel protein in schizophrenia neocortex, a deficit that is restored by antipsychotic drugs

  8. Describes localization in mouse brain of two isoforms - the longer is called b and the shorter is called a.

  9. Describes two rat isoforms of Kv3.1, alpha is the longer one and beta is the shorter one

  10. KChIP4a suppresses A-type Kv4 current via ER retention and enhancement of Kv4 closed-state inactivation.

  11. Although all KV3 subunit transcripts are significantly expressed at embryonic age in whole mouse brain extracts, only KV3.1, KV3.2 and KV3.4 subunit transgenic proteins are present.

  12. demonstrated that glycosylation was necessary for both DPP10 trafficking to the cell surface and functional interaction with Kv4 channels

  13. Kv3.1 channels are transported into axons by binding to kinesin I.

  14. In the absence of potassium ion, significant N-methyl-D-glucamine (NMDG)-positive currents could be recorded from human embryonic kidney cells expressing Kv3.1 or Kv3.2b channels and Kv1.5 Arg487Tyr/Val, but not wild-type channels.

Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 1 (KCNC1) Antigen Profile

Protein Summary

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Multiple transcript variants encoding different isoforms have been inferred for this gene based on orthologous loci.

Gene names and symbols associated with KCNC1

  • potassium voltage-gated channel subfamily C member 1 (KCNC1) antibody
  • potassium voltage-gated channel, Shaw-related subfamily, member 1 (kcnc1) antibody
  • potassium voltage gated channel, Shaw-related subfamily, member 1 (Kcnc1) antibody
  • potassium voltage-gated channel subfamily C member 1 (Kcnc1) antibody
  • potassium voltage-gated channel, Shaw-related subfamily, member 1a (kcnc1a) antibody
  • C230009H10Rik antibody
  • KCNC2 antibody
  • Kcr2-1 antibody
  • KShIIIB antibody
  • KV3.1 antibody
  • Kv4 antibody
  • NGK2 antibody
  • NGK2-KV4 antibody
  • Shaw antibody
  • zgc:194940 antibody
  • zgc:194950 antibody

Protein level used designations for KCNC1

potassium voltage-gated channel, Shaw-related subfamily, member 1 , potassium channel Kv3.1 , potassium voltage-gated channel subfamily C member 1 , voltage-gated potassium channel subunit Kv3.1 , voltage-gated potassium channel subunit Kv4 , NGK2 , RAW2 , potassium channel gene 1 , voltage-gated potassium channel protein KV3.1 , Shaw-related voltage-gated potassium channel protein 1 , potassium channel , voltage-gated potassium channel KCNC1 , kcnc1 , voltage-gated potassium channel Kv3.1a

GENE ID SPECIES
466452 Pan troglodytes
100020061 Monodelphis domestica
100056567 Equus caballus
100144433 Taeniopygia guttata
100144936 Xenopus (Silurana) tropicalis
16502 Mus musculus
25327 Rattus norvegicus
3746 Homo sapiens
423076 Gallus gallus
403705 Canis lupus familiaris
541459 Bos taurus
100008968 Oryctolagus cuniculus
565419 Danio rerio
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