anti-Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 (KCNC3) Antibodies

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Additionally we are shipping Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KCNC3 16504  
KCNC3 117101  
KCNC3 3748 Q14003
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Top anti-Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 Antibodies at antibodies-online.com

Showing 10 out of 101 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-KCNC3 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  293T cell lysate KCNC3 is supported by BioGPS gene expression data to be expressed in HEK293T WB Suggested Anti-KCNC3 antibody Titration: 1 ug/mL Sample Type: Human liver 100 μL 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB ABIN190903 (0.3µg/ml) staining of human brain (Frontal Cortex) lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg 6 to 7 Days
$429.84
Details
Mouse Goat Un-conjugated ELISA, WB   100 μg 6 to 7 Days
$429.84
Details
Mouse Goat Un-conjugated ELISA, WB 0.1 mg 2 to 3 Days
$515.63
Details
Guinea Pig Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Human Goat Un-conjugated ELISA, WB 100 μg 11 to 14 Days
$610.50
Details
Cow Goat Un-conjugated ELISA, WB 100 μg 11 to 14 Days
$610.50
Details
Mouse Goat Un-conjugated ELISA, WB 100 μg 11 to 14 Days
$610.50
Details
Human Goat Un-conjugated EIA, WB Staining of Mouse brain lysate (35 µg protein in RIPA buffer) using KCNC3 antibody at 0.3 µg/ml. Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg 6 to 8 Days
$445.50
Details
Human Rabbit Un-conjugated WB Western blot analysis in K562 cell line lysates (35ug/lane). 400 μL 2 to 3 Days
$515.63
Details

Top referenced anti-Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 Antibodies

  1. Human Polyclonal KCNC3 Primary Antibody for ELISA, WB - ABIN188843 : Waters, Minassian, Stevanin, Figueroa, Bannister, Nolte, Mock, Evidente, Fee, Müller, Dürr, Brice, Papazian, Pulst: Mutations in voltage-gated potassium channel KCNC3 cause degenerative and developmental central nervous system phenotypes. in Nature genetics 2006 (PubMed)

  2. Human Monoclonal KCNC3 Primary Antibody for IF, ELISA - ABIN561577 : Alaminos, González-Andrades, Muñoz-Avila, Garzón, Sánchez-Quevedo, Campos: Volumetric and ionic regulation during the in vitro development of a corneal endothelial barrier. in Experimental eye research 2008 (PubMed)

More Antibodies against Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 Interaction Partners

Mouse (Murine) Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 (KCNC3) interaction partners

  1. Kv3 transcripts and proteins show a progressive increase in expression and reached an asymptote in adulthood, suggesting that the increase in Kv3 expression during development might contribute to the maturation of the electrical activity of neurons.

  2. Dendritic Kv3.3 potassium channels in mice cerebellar purkinje cells regulate generation and spatial dynamics of dendritic Ca2+ spikes.

  3. Kv3.3 expression in Purkinje cells is necessary for normal motor speed but not gait pattern.

  4. Motor deficits and altered synaptic transmission at the parallel fiber-Purkinje cell synapse in Kv3.3 knockout mice.

  5. Double mutant Kv3.1/Kv3.3-deficient mice are constitutively hyperactive. Increased ambulatory and stereotypic activity in conjunction with sleep loss was seen in Kv3.1-single mutants but not in Kv3.3-single mutants.

  6. two voltage-gated potassium channels, Kv3.1 and Kv3.3, control sleep in wild-type and Kv3-mutant mice

  7. We conclude that the rate of spontaneous action potential firing of Purkinje neurons is controlled by the interaction of Kv3.3 potassium currents and resurgent sodium currents.

  8. In this study, we identified additional populations and subcellular compartments that are likely to sustain high-frequency firing because of the expression of Kv3.3 and other Kv3 subunits.

  9. Kv3.3 channels are required for generation of the repetitive spikelets of the complex spike.

  10. Purkinje-cell-restricted restoration of Kv3.3 function restores complex spikes and rescues motor coordination in Kcnc3 mutants.

  11. results support the hypothesis that altered electrophysiological properties of TRN neurons contribute to the reduced EEG power at slow frequencies in the thalamocortical network of Kv3-deficient mice.

  12. Kv3.3 potassium subunits are expressed in both GAD- and GAD+ cells, albeit at different densities and distribution. They likely contribute to the distinct biophysical properties of both GAD- and GAD+ neurons in the dentate nucleus.

Human Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 (KCNC3) interaction partners

  1. Study expanded the genotype-phenotype-pathophysiology repertoire of SCA13 by addition of a causative KCNC3 mutation, p.Pro583_Pro585del, its associated phenotype of profound spasticity, and the decreased inactivation rate of the mutant channel.

  2. results therefore confirm the KCNC3R423H allele as causative for SCA13, through a dominant negative effect on KCNC3WT and links with EGFR that account for dominant inheritance, congenital onset, and disease pathology

  3. This review covers the localization and physiological function of Kv3.3 in the central nervous system and how the normal function of the channel is altered by the disease-causing mutations

  4. Kv3.3 regulates Arp2/3-dependent cortical actin nucleation mediated by Hax-1; resulting cortical actin structures interact with the channel's gating machinery to slow its inactivation rate during sustained membrane depolarizations; a mutation that leads to late-onset spinocerebellar ataxia type 13.

  5. The Kv channels, or at least Kv3.3, appear to be associated with cell differentiation

  6. Functional and in silico analysis identified at least one novel pathogenic mutation in KCNC3 that cause Spinocerebellar ataxia type 13 (SCA13) and two additionally potential ones.

  7. investigated using either targeted next generation sequencing or trio-based exome sequencing and were found to have mutations in three different genes, KCNC3, ITPR1 and SPTBN2

  8. These results are specific to the KCNC3(R420H) allele and provide new insight into the molecular basis of disease manifestation in SCA13.

  9. Data indicate that an autosomal dominant mutation in the gene encoding Kv3.3 has been identified in a large Filipino kindred manifesting as spinocerebellar ataxia type 13 (SCA13).

  10. no disease-related KCNC3 mutation was identified, suggesting that spinocerebellar ataxia type 13 is a rare form of SCA in mainland China

  11. This study presented the results of a detailed neurological clinical and diagnostic testing on 21 mutation-positive members of a four-generation Filipino family to further define this disease, aiding diagnosis and prognosis.

  12. Data suggest that mutant forms of Kv3.3 (as seem in subjects with spinocerebellar ataxia-13) are unstable, are degraded through proteasomes at faster rates, and can be stabilized by a chemical chaperone.

  13. Kv3.3 gating contributes significantly to an early age of onset in spinocerebellar ataxia type 13

  14. The KCNC3 mutation casued Spinocerebellar ataxia 13.

  15. The spinocerebellar ataxia type 13 mutation of the KV3.3 gene specifically suppresses the excitability of Kv3.3-expressing, fast-spiking neurons in zebrafish

  16. Mutations in KCNC3 are a rare cause of spinocerebellar ataxia with a frequency of less than 1%.

  17. The p.Arg420His mutation, which results in a nonfunctional channel subunit, was recurrent and associated with late-onset progressive ataxia.

  18. results establish a role for KCNC3 in phenotypes ranging from developmental disorders to adult-onset neurodegeneration and suggest voltage-gated K+ channels as candidates for additional neurodegenerative diseases

  19. Mutations in the voltage-gated potassium channel KCNC3 are causative for spinocerebellar ataxia 13.

Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 3 (KCNC3) Antigen Profile

Protein Summary

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes.

Gene names and symbols associated with KCNC3

  • potassium voltage-gated channel subfamily C member 3 (KCNC3) antibody
  • potassium channel, voltage gated Shaw related subfamily C, member 1 S homeolog (kcnc1.S) antibody
  • potassium voltage gated channel, Shaw-related subfamily, member 3 (Kcnc3) antibody
  • potassium voltage-gated channel subfamily C member 3 (Kcnc3) antibody
  • potassium channel, voltage gated Shaw related subfamily C, member 3 L homeolog (kcnc3.L) antibody
  • potassium voltage-gated channel, Shaw-related subfamily, member 3 (KCNC3) antibody
  • kcnc1 antibody
  • kcnc3-A antibody
  • Kcr2-3 antibody
  • kshiiid antibody
  • Kv3.1 antibody
  • kv3.3 antibody
  • sca13 antibody

Protein level used designations for KCNC3

potassium voltage-gated channel, Shaw-related subfamily, member 3 , potassium voltage-gated channel subfamily C member 3-like , potassium voltage-gated channel subfamily C member 3 , voltage-gated potassium channel subunit Kv3.3 , Shaw-related voltage-gated potassium channel protein 3 , voltage-gated potassium channel protein KV3.3 , Shaw-related voltage-gated potassium channel protein 1 , potassium voltage gated channel, Shaw-related subfamily, member 1 , Shaw type potassium channel Kv3.3

GENE ID SPECIES
100454778 Pongo abelii
100589403 Nomascus leucogenys
373613 Xenopus laevis
16504 Mus musculus
117101 Rattus norvegicus
3748 Homo sapiens
779437 Xenopus laevis
617852 Bos taurus
100009368 Oryctolagus cuniculus
100511263 Sus scrofa
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