anti-Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1) Antibodies

RASSF1 encodes a protein similar to the RAS effector proteins. Additionally we are shipping Ras Association (RalGDS/AF-6) Domain Family Member 1 Kits (7) and Ras Association (RalGDS/AF-6) Domain Family Member 1 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RASSF1 11186 Q9NS23
RASSF1 56289 Q99MK9
RASSF1 363140  
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Top anti-Ras Association (RalGDS/AF-6) Domain Family Member 1 Antibodies at antibodies-online.com

Showing 10 out of 142 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-RASSF1 Antibody Titration: 1.0 ug/ml Positive Control: Fetal Lung 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p) Formalin-fixed and paraffin embedded rat brain labeled with Anti-RASSF1A Polyclonal Antibody, Unconjugated (ABIN673764) at 1:200 followed by conjugation to the secondary antibody and DAB staining. Formalin-fixed and paraffin-embedded human oral squamous cell labeled with Anti-RASSF1A Polyclonal Antibody, Unconjugated (ABIN673764) 1:200, overnight at 4°C, The secondary antibody was Goat Anti-Rabbit IgG, PE conjugated used at 1:200 dilution for 40 minutes at 37°C. 100 μL 3 to 7 Days
$329.45
Details
Mouse Goat Un-conjugated ELISA   100 μg 6 to 7 Days
$291.53
Details
Human Mouse Un-conjugated IHC, IHC (p), IP, WB Placenta, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Spleen, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 100 μg 11 to 14 Days
$639.83
Details
Human Rabbit Un-conjugated IF, IHC, WB Western blot analysis of extracts of various cell lines, using RASSF1 antibody. 100 μL 11 to 13 Days
$366.77
Details
Bat Goat Un-conjugated IHC, IHC (p) Brain, cortex, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Liver, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ICC, IF, WB ICC/IF Image Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using RASSF1, antibody at 1:100 dilution. WB Image Sample(30 ug whole cell lysate) A:293T 12% SDS PAGE diluted at 1:500 100 μL 3 to 4 Days
$466.18
Details
Human Mouse Un-conjugated FACS, IF, IHC, IHC (p), WB Anti-RASSF1 / RASSF1A antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. 50 μL 11 to 14 Days
$484.00
Details
Human Mouse Un-conjugated FACS, IF, WB 100 μL 11 to 14 Days
$522.50
Details
Human Mouse Un-conjugated FACS, IF, IHC, WB Anti-RASSF1 mouse monoclonal antibody (ABIN2454275) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY RASSF1 (RC213525). Immunohistochemical staining of paraffin-embedded Human breast tissue using anti-RASSF1 mouse monoclonal antibody. (ABIN2454275) 0.1 mL 2 to 3 Days
$462.00
Details

Top referenced anti-Ras Association (RalGDS/AF-6) Domain Family Member 1 Antibodies

  1. Human Monoclonal RASSF1 Primary Antibody for IF, ELISA - ABIN532916 : Chiu, Chim, Wong, Wong, Lee, To, Tong, Yuen, Shum, Chan, Chan, Yuen, Tong, Weier, Ferlatte, Leung, Lau, Lo, Lo: Hypermethylation of RASSF1A in human and rhesus placentas. in The American journal of pathology 2007 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal RASSF1 Primary Antibody for IF (p), IHC (p) - ABIN673764 : Liu, Ao, Zhou, Cui, Zhou, Yuan, Xiang, Cao, Liu: CpG island hypermethylation of multiple tumor suppressor genes associated with loss of their protein expression during rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine. in Biochemical and biophysical research communications 2010 (PubMed)
    Show all 2 Pubmed References

  3. Mouse (Murine) Polyclonal RASSF1 Primary Antibody for ELISA - ABIN451615 : Yan, Venkataramu, Ibrahim, Liu, Shen, Diaz, Centeno, Weber, Leu, Shapiro, Eng, Yeatman, Huang: Mapping geographic zones of cancer risk with epigenetic biomarkers in normal breast tissue. in Clinical cancer research : an official journal of the American Association for Cancer Research 2006 (PubMed)

  4. Human Polyclonal RASSF1 Primary Antibody for ICC, IF - ABIN442332 : Liu, Sun, Fong, Yang, Zhang, Yin, Jiang, Liu, Ju, Huang, Bai, Gong, Yan, Zhang, Shao: An association between overexpression of DNA methyltransferase 3B4 and clear cell renal cell carcinoma. in Oncotarget 2017 (PubMed)

  5. Human Monoclonal RASSF1 Primary Antibody for FACS, ICC - ABIN4349434 : Joo, Kim, Park, Yoo, Choe, Kim, Lee, Kim, Bak: CpG island promoter hypermethylation of Ras association domain family 1A gene contributes to gastric carcinogenesis. in Molecular medicine reports 2015 (PubMed)

More Antibodies against Ras Association (RalGDS/AF-6) Domain Family Member 1 Interaction Partners

Human Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1) interaction partners

  1. Hypermethylated p16 and RASSF1A cell-cycle inhibitor genes might be considered as biomarkers.

  2. This cascade induced by RASSF1A loss in bronchial cells is responsible for metastasis properties, YAP activation and cytokinesis defects.

  3. HOXA9, RASSF1A and SCGB3A1 promoter methylation significantly associated with testicular germ cell tumor stage.

  4. Methylation of ras association domain family member 1 (RASSF1A) genes is higher in hepatocellular carcinoma (HCC) patients than in patients with liver cirrhosis (LC). Methylation of RASSF1A gene is associated with age, tumor size, vascular invasion and alpha fetoprotein.

  5. Data provide a strong evidence for association involving RASSF1 methylation on bladder cancer risk. [review]

  6. Study show that hypoxia promotes stabilization of RASSF1A through NOX-1- and protein kinase C- dependent phosphorylation. HIF-1alpha activates RASSF1A transcription via HIF-binding sites in the RASSF1A promoter region. RASSF1A binds to HIF-1alpha, blocks its prolyl-hydroxylation and proteasomal degradation. Study concludes that RASSF1A-HIF-1alpha forms a feedforward loop driving hypoxia signaling in pulmonary hypertens...

  7. role for RASSF1A in tunneling nanotube formation between cells through GEFH1/Rab11 pathway control

  8. LINE-1 hypomethylation and RASSF1A promoter hypermethylation was found to be significantly correlated to early recurrence and poor prognosis in hepatocellular carcinoma

  9. Circ_0078767 and RASSF1A were downregulated, while miR-330-3p was upregulated in non-small-cell lung cancer (NSCLC) than that in adjacent tissues. miR-330-3p had a binding relationship with circ_0078767 and RASSF1A. The overexpression of circ_0078767 and RASSF1A or the underexpression of miR-330-3p significantly suppressed NSCLC cell viability.

  10. Study found reduced expression of RASSF1A with significant hypermethylation of its promoter region and its inactivation through epigenetic regulation may be important factor in tumorigenesis in substantial proportion of parathyroid adenomas.

  11. Tissues from patients with serous and non-serous EOC showed significantly higher promoter methylation of EGFL7 and RASSF1 compared to benign cases.

  12. Transcriptome assay unclosed that RASSF1A promoted IL-6 expression in A375 cells, which in turn activate JAK2/STAT3 signaling.

  13. Rassf1a rs2236947 is a promising biomarker for patients treated with cetuximab plus chemotherapy.

  14. Low RASSF1A expression is associated with gastric cancer.

  15. methylation of BRCA1, RASSF1A and GSTP1 was found in 58.23 %, 74.68 % and 59.49 % of tumor tissues and 51.90 %, 63.29 % and 35.44 % of corresponding adjacent tissues, respectively

  16. Our study established that RASSF1A hypermethylation might have a potential value in the clinical diagnosis of colorectal cancer

  17. Effect of decitabine pretreatment on sensitivity of bladder cancer cells towards chemotherapeutic drugs was also studied. Decitabine treatment leads to restoration of RASSF1A, activation of hippo pathway followed by decreased expression of its oncogenic downstream targets (CTGF & CYR61).

  18. the use of RASSF1A promoter methylation could distinguish ovarian cancer and low malignant potential tumors. -RASSF1A promoter methylation may not be correlated with the clinical features and the survival of ovarian cancer patients.

  19. the methylation positive rates of SHOX2 with RASSF1A in stage III were both higher than the other stages of lung cancer

  20. Tested if RASSF1A polymorphisms associated with ovarian cancer and with tumor grade and stage. Five tagging single nucleotide polymorphisms (SNPs) (rs4688728G>T, rs72932987C>T, rs1989839C>T, rs2073497A>C, and rs2236947A>C) were evaluated. The CT genotype of rs1989839 was associated with the patients with ovarian cancer (P=0.001), and was significantly correlated with tumor grade and stage (P=0.008).

Mouse (Murine) Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1) interaction partners

  1. Study show that hypoxia promotes stabilization of RASSF1A through NOX-1- and protein kinase C- dependent phosphorylation. HIF-1alpha activates RASSF1A transcription via HIF-binding sites in the RASSF1A promoter region. RASSF1A binds to HIF-1alpha, blocks its prolyl-hydroxylation and proteasomal degradation. Study concludes that RASSF1A-HIF-1alpha forms a feedforward loop driving hypoxia signaling in pulmonary hypertens...

  2. The authors found that haploinsufficiency of Rassf1a was sufficient to dramatically enhance the tumorigenicity of K-Ras in the system.

  3. RASSF1A is expressed in differentiating stem cells.RASSF1A promotes YAP and p73 binding to differentiation related genes.RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73.

  4. beta-catenin was predominantly associated with Na+/H+ exchanger regulating factor 1 (NHERF1) in a dynamic context and an increase of its oncogenic function through RAS-association domain family 1, isoform A (RASSF1A) inactivation in liver metastases.

  5. essential role of RASSF1A in regulating TNF-alpha signalling in cardiomyocytes, with RASSF1A being key in the formation of the TNFR complex and in signal transmission to the downstream targets

  6. RASSF1A may function to interfere and restrict TLR-driven activation of NF-kappaB and is essential for protection against inflammation-induced injury.

  7. nickel-smelting fumes upregulated the expression of RASSF1A. This suggest that nickel-smelting fumes could be toxic to cells, inducing cell apoptosis and necrosis.

  8. Loss of RASSF1A synergizes with deregulated RUNX2 signaling in tumorigenesis.

  9. Concomitant with the loss of Rassf1a, the loss of p53 (which causes unrestrained propagation of tetraploids into aneuploid cells) further undermines genomic stability and accelerates tumorigenesis.

  10. Data show that methylation of CCND-2, p16, RAR-beta and RASSF-1a was significantly more prevalent in tumor than in normal tissue specimens.

  11. Deletion of this gene increases cancer susceptibility in mice.

  12. Rassf1A acts as a tumor suppressor gene.

  13. cooperation between inactivation of Rassf1a and Apc resulting in accelerated intestinal tumourigenesis.

  14. RASSF1A mediates p21Cip1/Waf1-dependent cell cycle arrest and senescence through modulation of the Raf-MEK-ERK pathway and inhibition of Akt.

  15. data establish RASSF1A as a novel inhibitor of cardiac hypertrophy by modulating the extracellular regulated kinase 1/2 pathway.

Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1) Antigen Profile

Protein Summary

This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Gene names and symbols associated with RASSF1

  • NPR2-like, GATOR1 complex subunit (NPRL2) antibody
  • Ras association (RalGDS/AF-6) domain family 1 (rassf1) antibody
  • Ras association domain family member 1 (RASSF1) antibody
  • putative rassf1 (Smp_157340) antibody
  • Ras association domain family member 1 L homeolog (rassf1.L) antibody
  • Ras association (RalGDS/AF-6) domain family member 1 (Rassf1) antibody
  • Ras association domain family member 1 (Rassf1) antibody
  • 123F2 antibody
  • AA536941 antibody
  • AU044980 antibody
  • NORE2A antibody
  • RASSF1 antibody
  • Rassf1A antibody
  • Rassf1B antibody
  • Rassf1C antibody
  • RDA32 antibody
  • REH3P21 antibody
  • wu:fc17f02 antibody
  • zgc:92505 antibody
  • zgc:112224 antibody

Protein level used designations for RASSF1

Ras association (RalGDS/AF-6) domain family 1 , Ras association (RalGDS/AF-6) domain family member 1 , ras association domain-containing protein 1 , Ras association domain family 1 , rassf1 , WUGSC:H_LUCA12.5 , cardiac-specific ras association domain family 1 protein , pancreas-specific ras association domain family 1 protein , tumor suppressor protein RDA32 , 123F protein , RASSF1A tumor suppressor , protein 123F2

GENE ID SPECIES
425132 Gallus gallus
447811 Danio rerio
702385 Macaca mulatta
744944 Pan troglodytes
8344706 Schistosoma mansoni
100036863 Xenopus laevis
100302080 Ovis aries
11186 Homo sapiens
56289 Mus musculus
363140 Rattus norvegicus
607929 Canis lupus familiaris
510276 Bos taurus
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