SETD7 Proteins

(SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

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SETD7 Protein (AA 1-366) (His tag)

custom-made SETD7 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

AlphaFold protein structure predicition of Mouse Recombinant Setd7 Protein, UniprotID Q8VHL1

3 images

Catalog No. ABIN7564766

Details

SETD7 Protein (AA 1-366) (His tag)

custom-made SETD7 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

AlphaFold protein structure predicition of Human Recombinant SETD7 Protein, UniprotID Q8WTS6

3 images

Catalog No. ABIN7555491

Details

SETD7 Protein (AA 1-366) (His tag)

SETD7 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Catalog No. ABIN7504524

Details

SETD7 Protein (His tag)

SETD7 Origin: Human Host: Escherichia coli (E. coli) Recombinant SDS, WB, ELISA

Catalog No. ABIN7579445

Details

SETD7 Protein (AA 1-366) (Strep Tag)

custom-made SETD7 Origin: Mouse Host: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). SDS, WB, ELISA

Catalog No. ABIN3136750

Details

SETD7 Protein (AA 1-366) (Strep Tag)

custom-made SETD7 Origin: Human Host: Cell-free protein synthesis (CFPS) Recombinant approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). SDS, WB, ELISA

Catalog No. ABIN3095428