The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. [provided by RefSeq, Jul 2008].
Kim, Denli, Wright, Baul, Clemenson, Morcos, Zhao, Schafer, Gage, Kagalwala: "REST Regulates Non-Cell-Autonomous Neuronal Differentiation and Maturation of Neural Progenitor Cells via Secretogranin II." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 44, pp. 14872-84, (2015) (PubMed).
Aliases for SCG2 Proteins
secretogranin II L homeolog (scg2.L) Proteins secretogranin II (chromogranin C), b (scg2b) Proteins secretogranin II (scg2) Proteins secretogranin II (SCG2) Proteins Secretogranin-2 (scg2) Proteins secretogranin II (Scg2) Proteins Chcg Proteins CHGC Proteins Chgc Proteins DKFZp459O193 Proteins EM66 Proteins LOC397939 Proteins MGC84703 Proteins MGC145924 Proteins scg2 Proteins SCG2 Proteins SCGG2 Proteins SgII Proteins SN Proteins wu:fj34e01 Proteins zgc:153925 Proteins