anti-Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) Antibodies

Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. Additionally we are shipping SIGLEC8 Kits (20) and SIGLEC8 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIGLEC8 27181 Q9NYZ4
SIGLEC8    
SIGLEC8    
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Top anti-SIGLEC8 Antibodies at antibodies-online.com

Showing 10 out of 80 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Goat Un-conjugated ELISA, WB ABIN308467 (0.3µg/ml) staining of MOLT4 lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$429.84
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Goat Un-conjugated ELISA, WB 100 μg Log in to see 11 to 14 Days
$610.50
Details
Human Rabbit Un-conjugated IHC (p), WB SIGLEC8 Antibody (N-term) (ABIN658485) western blot analysis in HepG2 cell line lysates (35 µg/lane). This demonstrates the SIGLEC8 antibody detected the SIGLEC8 protein (arrow). 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated IHC (p), WB The anti-Siglec8 C-term Pab (ABIN388420) is used in Western blot to detect Siglec8 in mouse liver tissue lysate (lnae 1) and in HL60 cell lysate (lane 2). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Mouse PE FACS Detection of Siglec-8 in Human Blood Granulocytes by Flow Cytometry. Human peripheral blood granulocytes were stained with Rat Anti-Human CCR3 APC-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$363.86
Details
Human Mouse Alexa Fluor 488 FACS Detection of Siglec-8 in Human Blood Granulocytes by Flow Cytometry. Human peripheral blood granulocytes were stained with Rat Anti-Human CCR3 APC-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$385.33
Details
Human Mouse Alexa Fluor 700 FACS Detection of Siglec-8 in Human Blood Granulocytes by Flow Cytometry. Human peripheral blood granulocytes were stained with Rat Anti-Human CCR3 PE-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$385.33
Details
Human Mouse APC FACS Detection of Siglec-8 in Human Blood Granulocytes by Flow Cytometry. Human peripheral blood granulocytes were stained with Rat Anti-Human CCR3 PE-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$406.80
Details
Human Mouse PerCP FACS Detection of Siglec-8 in Human Blood Granulocytes by Flow Cytometry. Human peripheral blood granulocytes were stained with Rat Anti-Human CCR3 Fluorescein-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$418.10
Details

Top referenced anti-SIGLEC8 Antibodies

  1. Human Polyclonal SIGLEC8 Primary Antibody for IHC (p), ELISA - ABIN544598 : Foussias, Yousef, Diamandis: Molecular characterization of a Siglec8 variant containing cytoplasmic tyrosine-based motifs, and mapping of the Siglec8 gene. in Biochemical and biophysical research communications 2000 (PubMed)
    Show all 3 Pubmed References

  2. Polyclonal SIGLEC8 Primary Antibody for ELISA, WB - ABIN539676 : Nutku, Aizawa, Hudson, Bochner: Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis. in Blood 2003 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal SIGLEC8 Primary Antibody for ELISA, WB - ABIN449557 : Yokoi, Choi, Hubbard, Lee, Canning, Lee, Ryu, von Gunten, Bickel, Hudson, Macglashan, Bochner: Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement. in The Journal of allergy and clinical immunology 2008 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal SIGLEC8 Primary Antibody for ELISA, WB - ABIN565353 : von Gunten, Vogel, Schaub, Stadler, Miescher, Crocker, Simon: Intravenous immunoglobulin preparations contain anti-Siglec-8 autoantibodies. in The Journal of allergy and clinical immunology 2007 (PubMed)

More Antibodies against SIGLEC8 Interaction Partners

Human Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) interaction partners

  1. In differentiating ,eosinophils, SIGLEC-8 messenger RNA and protein were markedly down-regulated in parallel with OLIG2 by an OLIG2 small interfering RNA or a short hairpin RNA. An E-box in the first intron was found to stimulate SIGLEC-8 gene transcription and to bind OLIG2.

  2. miR-215 acts in concert with the host gene IARS2 to affect neuron migration and proliferation through the target gene SIGLEC-8.

  3. Our study suggested that intratumoral Siglec-8 expression was an independent prognostic factor for overall survival of patients with gastric cancer

  4. Ligands for Siglec-8 and Siglec-9 may regulate the function of eosinophils, mast cells, neutrophils, and other cells in sinus mucosa.

  5. Inflammation results in up-regulation of immuneinhibitory Siglec-8 and Siglec-9 sialoglycan ligands on human airways.

  6. Siglec-8 expression is sensitive to tiotropium and formoterol, indicating that it may be involved in COPD pathogenesis and may influence COPD phenotyping

  7. In activated eosinophils ligation of Siglec-8 leads to ROS-dependent enhancement of IL-5-induced ERK phosphorylation, which results in a novel mode of biochemically regulated eosinophil cell death.

  8. Engagement of Siglec-8 on blood eosinophils results in caspase- and mitochondria-dependent apoptosis.

  9. Report the development of a sensitive competitive ELISA to detect sSiglec-8 in human serum samples obtained from patients with various forms of eosinophilia.

  10. Eosinophils primed by IL-33 and/or IL-5 in vivo would be expected to display enhanced susceptibility to undergoing Siglec-8-induced apoptosis.

  11. expressed on eosinophils and basophils from subjects with chronic eosinophilic leukemia, chronic myelogenous leukemia, and on malignant and non-malignant bone marrow mast cells

  12. The Siglec-8 gene may be a susceptibility locus for asthma.

  13. Sialic acid binding immunoglobulin-like lectin 8 (Siglec-8) cross-linking with antibodies rapidly generated caspase-3-like activity and reduced eosinophil viability through induction of apoptosis

  14. Siglec-8 binds preferentially to a sLex structure bearing an additional sulfate ester on the galactose 6-hydroxyl

  15. Siglec-8-induced apoptosis in eosinophils occurs through the sequential production of reactive oxygen species, followed by induction of mitochondrial injury and caspase cleavage.

  16. IL-5 priming enhances Siglec-8-mediated mitochondrial and ROS-dependent eosinophil apoptosis and eliminates caspase dependence.

  17. First reported inhibitory effects of Siglec engagement on human mast cells.

  18. A review of the cytotoxic effects of natural anti-Siglec8 autoantibodies on both neutrophils and eosinophils.

  19. REVIEW: Siglec-8 and Siglec-F function on human eosinophils, and Siglec-8 function on mast cells

  20. Selective and specific engagement and binding of Siglec-8 on eosinophils by a synthetic 6'-sulfo-sLe(x)-containing ligand could be useful for controlling eosinophilic inflammatory responses in vivo.

SIGLEC8 Antigen Profile

Protein Summary

Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM\\\\; MIM 603492) that mediates an association with SLAM-associated protein (SAP\\\\; MIM 300490) (summarized by Foussias et al., 2000

Gene names and symbols associated with SIGLEC8

  • sialic acid binding Ig like lectin 8 (SIGLEC8) antibody
  • sialic acid-binding Ig-like lectin 8 (LOC506364) antibody
  • SAF2 antibody
  • SIGLEC-8 antibody
  • SIGLEC8 antibody
  • SIGLEC8L antibody

Protein level used designations for SIGLEC8

CDw329 , SAF-2 , sialic acid-binding Ig-like lectin 8 , sialoadhesin family member 2 , sialic acid binding Ig-like lectin 8

GENE ID SPECIES
27181 Homo sapiens
456249 Pan troglodytes
506364 Bos taurus
100595640 Nomascus leucogenys
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