SIGLEC8 antibody (Extracellular Domain)

Catalog No. ABIN7013899

The Mouse Monoclonal anti-SIGLEC8 antibody is suitable to detect SIGLEC8 in samples from Human. It has been validated for IP, ELISA and FACS.

Quick Overview for SIGLEC8 antibody (Extracellular Domain) (ABIN7013899)

Target: SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SIGLEC8 antibody is un-conjugated

Application: Immunoprecipitation (IP), ELISA, Flow Cytometry (FACS)

Clone: 7C9

Product Details anti-SIGLEC8 Antibody

Binding Specificity: Extracellular Domain

Purpose: Anti-Hu SIGLEC8 Purified

Characteristics: The mouse monoclonal antibody 7C9 recognizes an extracellular epitope of SIGLEC8, an eosinophil marker, expressed e.g. in lymph nodes and spleen.

Purification: Purified by protein-A affinity chromatography.

Immunogen: Extracellular domain of human SIGLEC8 fused with Fc fragment of human IgG1

Isotype: IgG1

Application Details

Application Notes: Flow cytometry: Recommended dilution: 1-4 μg/mL

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

Target Details for SIGLEC8

Target: SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))

Alternative Name: SIGLEC8

Background: Sialic acid binding Ig like lectin 8,SIGLEC8 is a sialic acid binding lectin similar to CD33. In its cytoplasmic comain it contains an immunoreceptor tyrosine-based inhibitory motif (ITIM), and a motive similar to a binding site for SLAM-associated protein. SIGLEC8 is expressed e.g. in lymph nodes and spleen. It is an eosinophil marker, although it can be found also on the surface of mast cells. Crosslinking of SIGLEC8 leads to apoptosis. Soluble form of SIGLEC8 can be foud in human serum, especially in case of eosinophil-associated diseases.,SAF2

Gene ID: 27181

UniProt: Q9NYZ4