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SIGLEC8 antibody (Extracellular Domain)

SIGLEC8 Reactivity: Human ELISA, IP, FACS Host: Mouse Monoclonal 7C9 unconjugated
Catalog No. ABIN7013899
  • Target See all SIGLEC8 Antibodies
    SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))
    Binding Specificity
    • 8
    • 7
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Extracellular Domain
    Reactivity
    • 42
    • 7
    • 2
    Human
    Host
    • 33
    • 8
    • 1
    Mouse
    Clonality
    • 35
    • 7
    Monoclonal
    Conjugate
    • 23
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SIGLEC8 antibody is un-conjugated
    Application
    • 33
    • 19
    • 19
    • 7
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    ELISA, Immunoprecipitation (IP), Flow Cytometry (FACS)
    Specificity
    The mouse monoclonal antibody 7C9 recognizes an extracellular epitope of SIGLEC8, an eosinophil marker, expressed e.g. in lymph nodes and spleen.
    Purification
    Purified by protein-A affinity chromatography.
    Immunogen
    Extracellular domain of human SIGLEC8 fused with Fc fragment of human IgG1
    Clone
    7C9
    Isotype
    IgG1
    Top Product
    Discover our top product SIGLEC8 Primary Antibody
  • Application Notes
    Flow cytometry: Recommended dilution: 1-4 μg/mL
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store at 2-8°C. Do not freeze.
  • Target
    SIGLEC8 (Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8))
    Alternative Name
    SIGLEC8 (SIGLEC8 Products)
    Synonyms
    SAF2 antibody, SIGLEC-8 antibody, SIGLEC8L antibody, SIGLEC8 antibody, sialic acid binding Ig like lectin 8 antibody, sialic acid-binding Ig-like lectin 8 antibody, SIGLEC8 antibody, LOC506364 antibody
    Background
    Sialic acid binding Ig like lectin 8,SIGLEC8 is a sialic acid binding lectin similar to CD33. In its cytoplasmic comain it contains an immunoreceptor tyrosine-based inhibitory motif (ITIM), and a motive similar to a binding site for SLAM-associated protein. SIGLEC8 is expressed e.g. in lymph nodes and spleen. It is an eosinophil marker, although it can be found also on the surface of mast cells. Crosslinking of SIGLEC8 leads to apoptosis. Soluble form of SIGLEC8 can be foud in human serum, especially in case of eosinophil-associated diseases.,SAF2
    Gene ID
    27181
    UniProt
    Q9NYZ4
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