anti-Sirtuin 2 (SIRT2) Antibodies

SIRT2 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Additionally we are shipping Sirtuin 2 Kits (29) and Sirtuin 2 Proteins (19) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIRT2 22933 Q8IXJ6
SIRT2 64383 Q8VDQ8
SIRT2 361532 Q5RJQ4
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Top anti-Sirtuin 2 Antibodies at antibodies-online.com

Showing 10 out of 129 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-SIRT2 Picoband antibody, IHC(P): Rat Brain Tissue Anti-SIRT2 Picoband antibody, IHC(P): Mouse Brain Tissue 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Human Brain, Cerebellum (formalin-fixed, paraffin-embedded) stained with SIRT2at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Human Heart (formalin-fixed, paraffin-embedded) stained with SIRT2at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, IHC (p), WB Immunofluorescence: Sirtuin 2/SIRT2 Antibody [NBP1-76879] - Human Brain tissue with SIRT2 antibody at 5 ug/mL. Immunohistochemistry: Sirtuin 2/SIRT2 Antibody [NBP1-76879] - Immunohistochemical staining of Human Brain tissue using SIRT2 antibody at 2.5 ug/mL. 0.1 mg Log in to see 8 to 11 Days
$485.88
Details
Human Rabbit Un-conjugated IHC, WB 100 μg Log in to see 2 to 3 Days
$335.00
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: SIRT2 Antibody [NBP1-87039] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY402172) Immunohistochemistry-Paraffin: SIRT2 Antibody [NBP1-87039] - Staining of human colon shows strong cytoplasmic and membranous positivity in glandular cells. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 2 to 3 Days
$245.00
Details
Rat Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Rat Brain Tissue; Lane2: Mouse Brain Tissue. 100 μg Log in to see 15 to 18 Days
$342.00
Details
Guinea Pig Rabbit Un-conjugated IHC (p), WB Brain, cortex 50 μg Log in to see 7 to 9 Days
$727.83
Details

SIRT2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Sirtuin 2 Antibodies

  1. Human Polyclonal SIRT2 Primary Antibody for ELISA, ICC - ABIN4353911 : Zhao, Mo, Li, Zou, Cheng, Sun, Xiong, Guan, Lei: NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells. in The Journal of clinical investigation 2014 (PubMed)

  2. Human Monoclonal SIRT2 Primary Antibody for WB - ABIN2668611 : Pandithage, Lilischkis, Harting, Wolf, Jedamzik, Lüscher-Firzlaff, Vervoorts, Lasonder, Kremmer, Knöll, Lüscher: The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility. in The Journal of cell biology 2008 (PubMed)

  3. Human Polyclonal SIRT2 Primary Antibody for ICC, IF - ABIN2668615 : Dryden, Nahhas, Nowak, Goustin, Tainsky: Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. in Molecular and cellular biology 2003 (PubMed)

  4. Mouse (Murine) Polyclonal SIRT2 Primary Antibody for ICC, IF - ABIN2668616 : Southwood, Peppi, Dryden, Tainsky, Gow: Microtubule deacetylases, SirT2 and HDAC6, in the nervous system. in Neurochemical research 2007 (PubMed)

  5. Cow (Bovine) Polyclonal SIRT2 Primary Antibody for WB - ABIN2779604 : Borra, Langer, Slama, Denu: Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases. in Biochemistry 2004 (PubMed)
    Show all 2 Pubmed References

  6. Human Polyclonal SIRT2 Primary Antibody for IHC, IHC (p) - ABIN4353913 : Bajpe, Prahallad, Horlings, Nagtegaal, Beijersbergen, Bernards: A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity. in Oncogene 2015 (PubMed)

More Antibodies against Sirtuin 2 Interaction Partners

Fruit Fly (Drosophila melanogaster) Sirtuin 2 (SIRT2) interaction partners

  1. Sirt2 has an role in the regulation of mitochondrial energy metabolism.

Arabidopsis thaliana Sirtuin 2 (SIRT2) interaction partners

  1. SRT2 is important in fine-tuning mitochondrial energy metabolism.

  2. AtSRT2 is a deacetylase that negatively regulates the plant basal defense and PR1 (show TMEM37 Antibodies) expression.

Human Sirtuin 2 (SIRT2) interaction partners

  1. SIRT2 inhibition may improve microtubule assembly thus representing a valid approach as disease-modifying therapy for Alzheimer's disease.

  2. Data show that single nucleotide polymorphism rs2015C in sirtuin 2 protein (SIRT2) gene 3'-UTR (show UTS2R Antibodies) was significantly associated with increased risk of colorectal cancer (CRC (show CALR Antibodies)).

  3. Authors show that SIRT2 is downregulated in insulin-resistant hepatocytes and livers, and this was accompanied by increased generation of reactive oxygen species, activation of stress-sensitive ERK1/2 kinase, and mitochondrial dysfunction.

  4. Those findings highlight the potential role of SIRT2 in HBV and HBV-mediated HCC (show FAM126A Antibodies) by interaction with HBx.

  5. The SIRT2 functions as a mitochondrial sirtuin (show SIRT1 Antibodies), as well as a regulator of autophagy/mitophagy to maintain mitochondrial biology, thus facilitating cell survival.

  6. increased expression of SRF that was observed in the aged heart may affect SIRT2 gene expression and contribute to altered metabolic status in senescence

  7. SIRT2 and RIPK1 (show RIPK1 Antibodies) were localized to the syncytiotrophoblast, villous leukocytes and vasculature in all preterm placentas. A significant reduction in SIRT2 protein expression in both preeclampsia and fetal growth restricted placentas was identified. Immunofluorescence identified both SIRT2 and RIPK1 (show RIPK1 Antibodies) in the cytotrophoblast cytoplasm.

  8. mutations in sirtuin2 increase the stability of the conserved catalytic sirtuin (show SIRT1 Antibodies) domain, thereby increasing the catalytic efficiency of the mutant enzymes.

  9. targeting SIRT2 may be a rational strategy for diminishing Slug abundance and its associated malignant traits in basal-like breast cancer.

  10. BEX4 (show BEX4 Antibodies) overexpression causes an imbalance between TUB (show TUB Antibodies) acetylation and deacetylation by SIRT2 inhibition and induces oncogenic aneuploidy transformation.

Cow (Bovine) Sirtuin 2 (SIRT2) interaction partners

  1. The results indicate that the variations in the class I sirtuin (show SIRT1 Antibodies) genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  2. An association analysis showed that the two loci of SIRT2 were significantly correlated with some body size traits and the H2H2 (-CT-CT (show CALCA Antibodies)-) diplotypes performed better than other combinations.

  3. Data suggest that the silent information regulator 2 (SIRT2) gene may be a candidate gene for marker-assisted selection in the development of breeding programs for Qinchuan cattle.

Mouse (Murine) Sirtuin 2 (SIRT2) interaction partners

  1. SIRT2 inhibition may improve microtubule assembly thus representing a valid approach as disease-modifying therapy for Alzheimer's disease.

  2. Authors show that SIRT2 is downregulated in insulin-resistant hepatocytes and livers, and this was accompanied by increased generation of reactive oxygen species, activation of stress-sensitive ERK1/2 kinase, and mitochondrial dysfunction.

  3. Given the significance of KRAS activity as a driver in tumorigenesis, identification of K147 acetylation as a novel post-translational modification directed by SIRT2 in vivo may provide a better understanding of the mechanistic link regarding the crosstalk between non-genetic and genetic factors in KRAS driven tumors.

  4. SIRT2 modulates microvascular inflammation in sepsis and affects survival

  5. This study showed that Sirt2-dependent GKRP (show GCKR Antibodies) deacetylation improves impaired HGU and suggest that it may be a therapeutic target for type 2 diabetes.

  6. AMPK (show PRKAA1 Antibodies) and Sirt2 control compensatory glucose uptake in metabolically arrested mitochondria.

  7. SIRT2 promotes AMPK (show PRKAA1 Antibodies) activation by deacetylating the kinase LKB1 (show STK11 Antibodies). Loss of SIRT2 reduces AMPK (show PRKAA1 Antibodies) activation, promotes aging-related and Ang II (show AGT Antibodies)-induced cardiac hypertrophy, and blunts metformin-mediated cardioprotective effects.

  8. found a decreased ratio of dopaminergic neurons in primary midbrain cultures treated with the SIRT2 inhibitor AK-7 (show AK7 Antibodies)

  9. mitochondrial dysfunction triggers LKB1 (show STK11 Antibodies)-mediated AMPK (show PRKAA1 Antibodies) activation, which stimulates Sirt2 phosphorylation, leading to activation of mTOR (show FRAP1 Antibodies)-RAPTOR (show RPTOR Antibodies) and Glut1 (show SLC2A1 Antibodies)-mediated glucose uptake.

  10. SIRT-2 regulates microvascular inflammation in obese mice with sepsis.

Sirtuin 2 (SIRT2) Antigen Profile

Protein Summary

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.

Gene names and symbols associated with anti-Sirtuin 2 (SIRT2) Antibodies

  • Sirtuin 2 (Sirt2) antibody
  • sirtuin 2 (SIRT2) antibody
  • sirtuin 2 S homeolog (sirt2.S) antibody
  • NAD-dependent deacetylase sirtuin 2 homolog (Sirt2) antibody
  • sirtuin 2 (SRT2) antibody
  • sirtuin 2 (sirt2) antibody
  • sirtuin 2 (Sirt2) antibody
  • sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae) (sirt2) antibody
  • 5730427M03Rik antibody
  • AtSRT2 antibody
  • BmSirt2 antibody
  • CG5085 antibody
  • D.mel2 antibody
  • Dmel\\CG5085 antibody
  • dSIRT2 antibody
  • SIR2 antibody
  • Sir2l antibody
  • SIR2L2 antibody
  • Sirt2 antibody
  • sirtuin 2 antibody
  • T2K12.8 antibody
  • wu:fb57d05 antibody
  • zgc:55966 antibody
  • zgc:77003 antibody

Protein level used designations for anti-Sirtuin 2 (SIRT2) Antibodies

CG5085-PA , Sirt2-PA , sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) , sirtuin 2 , NAD-dependent deacetylase SIRT2 , NAD-dependent deacetylase sirtuin-2 , histone NADC , silent information regulator 2 , nicotinamide adenine dinucleotide-dependent histone deacetylase , NAD-dependent deacetylase sirtuin 2 homolog , NAD-dependent protein deacetylase sirtuin-2 , SIR2-like protein 2 , regulatory protein SIR2 homolog 2 , sir2-related protein type 2 , sirtuin type 2 , sirtuin-like protein 2 , mSIR2L2 , silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2 , 5E5 antigen

GENE ID SPECIES
42414 Drosophila melanogaster
456013 Pan troglodytes
495688 Xenopus laevis
548628 Gallus gallus
612558 Canis lupus familiaris
692483 Bombyx mori
830782 Arabidopsis thaliana
100380582 Salmo salar
22933 Homo sapiens
100125964 Sus scrofa
504463 Bos taurus
64383 Mus musculus
361532 Rattus norvegicus
100172430 Pongo abelii
322309 Danio rerio
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