SIRT2 antibody

Catalog No. ABIN1169092

This Mouse Monoclonal antibody specifically detects SIRT2 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for SIRT2 antibody (ABIN1169092)

Target: SIRT2 (Sirtuin 2 (SIRT2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SIRT2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: S2R233-1

Product Details anti-SIRT2 Antibody

Purpose: anti-Sirtuin 2 (human), mAb (S2R233-1)

Specificity: Recognizes human sirtuin 2. Detects a band of ~45 kDa by Western blot.

Characteristics: Monoclonal Antibody. Recognizes human sirtuin 2. Detects a band of ~45 kDa by Western blot. Isotype: Mouse IgG2bkappa. Clone: S2R233-1. Applications: ELISA, WB. Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. Sirtuin-2 is a NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of a-tubulin. It is involved in the control of mitotic exit in the cell cycle. Furthermore, a variety of age-associated diseases such as type 2 diabetes, obesity, osteoporosis, and Alzheimer's disease are associated with sirtuins. Selective inhibition of Sirtuin-2 achieves neuroprotection and identifies Sirtuin-2 to be a potential therapeutic avenue in Huntington's and Parkinson's disease.

Sterility: 0.2 μm filtered

Immunogen: Recombinant human sirtuin 2.

Isotype: IgG2b kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.2μm-filtered solution in PBS, pH 7.4.

Preservative: Without preservative

Handling Advice: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment:

+4°C

-20°C

Stable for at least 1 year after receipt when stored at -20°C.

Expiry Date: 12 months

Target Details for SIRT2

Target: SIRT2 (Sirtuin 2 (SIRT2))

Alternative Name: Sirtuin 2

Background:

Alternate Names/Synonyms: SIRT2, NAD-dependent Deacetylase Sirtuin-2, SIR2-like protein 2, SIR2L2

Product Description: Sirtuin-2 is a NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of a-tubulin. It is involved in the control of mitotic exit in the cell cycle. Furthermore, a variety of age-associated diseases such as type 2 diabetes, obesity, osteoporosis, and Alzheimer's disease are associated with sirtuins. Selective inhibition of Sirtuin-2 achieves neuroprotection and identifies Sirtuin-2 to be a potential therapeutic avenue in Huntington's and Parkinson's disease.

UniProt: Q8IXJ6