Sirtuin 3 Proteins (SIRT3)

Human Sirtuin 3 (SIRT3) interaction partners

1. SIRT3 could be a target for colon cancer.

2. these results identified a tumor-suppressive role for Sirt3 deficiency in tongue cancer via activation of the JNK-Fis1 axis and subsequent initiation of fatal mitochondrial fission.

3. SIRT3 promoted mitochondrial biogenesis by increasing both the expression and deacetylation of TFAM in clear cell renal cell carcinoma.

4. that SIRT3 dysfunction leads to p53-mediated mitochondrial and neuronal damage in Alzheimer's disease

5. Myricetin nanoliposomes induced SIRT3-mediated glycolytic metabolism leading to glioblastoma cell death.

6. High SIRT3 expression is associated with diabetes and hypothyroidism.

7. SIRT3 knockout cells upregulated the diversion of glutamine into de novo nucleotide synthesis through hyperactive mTORC1 signaling.

8. Increased levels of miR-195 in failing myocardium regulate a novel pathway that involves direct SIRT3 suppression and enzymatic inhibition via increased acetylation of pyruvate dehydrogenase and ATP synthase that are essential for cardiac energy metabolism.

9. The Sirt3-mediated protein deacetylation plays an important role in regulating oxidative metabolism and antioxidant defence in stem cell differentiation, and that Sirt3 deficiency may be related to insulin resistance.

10. SIRT3 gene expression is altered in adipose tissue from overweight and obese subjects compared to normal weight subjects.

11. MiR-494-3p inhibition exerted a neuroprotective role in 1-Methyl-4-phenylpyridinium induced Parkinson's disease by targeting SIRT3, providing a possible therapeutic strategy for Parkinson's disease patients.

12. ZEB1 silenced SIRT3 expression via interaction with MBD1 to promote aerobic glycolysis in pancreatic cancer.

13. The SIRT3 promoted FOXO3A expression by attenuating Wnt/beta-catenin pathway, thereby inhibiting EMT and migration of prostate cancer cells.

14. Sirtuin-3 mitochondrial NAD-dependent deacetylase (SIRT3) is responsible for serine hydroxymethyltransferase 2 (SHMT2)deacetylation in colorectal cancer (CRC) cells. The increased expression of SIRT3 in human CRC samples is correlated with poorer postoperative overall survival.

15. genetic manipulation of Sirt3 revealed that amyloid-beta increased levels of total tau acetylated tau through its modulation of Sirt3.

16. The SIRT3 protein level negatively correlated with advanced glycation end products accumulation and the grade of intervertebral disc degeneration degeneration.

17. Melatonin's functions in the mitochondria are highly diverse, not unlike those of sirtuin 3 (SIRT3). SIRT3 is an NAD+-dependent deacetylase which regulates, among many functions, the redox state of the mitochondria. Recent data proves that melatonin and SIRT3 post-translationally collaborate in regulating free radical generation and removal from mitochondria. [review]

18. Master athletes had lower levels of miR-7, while mRNA or protein levels of SIRT3, SIRT1, SOD2, and FOXO1 levels were significantly higher in the vastus lateralis muscle of master athletes compared to muscles of age-matched controls.

19. BER modulated autophagy in DOX-treated H9c2 cardiomyoblasts. Interestingly, mitochondrial biogenesis markers were upregulated in in BER/DOX-treated cells. Sirt3 over-expression contributes to decrease DOX cytotoxicity on H9c2 cardiomyoblasts, while BER can be used as a modulator of Sirtuin function and cell quality control pathways to decrease DOX toxicity.

20. The loss of Sirt3 triggered fatal mitochondrial fission by suppressing the Akt/PTEN pathway.

Mouse (Murine) Sirtuin 3 (SIRT3) interaction partners

1. Sirt3 plays an important role in regulating Abeta-induced cerebral hypometabolism in mouse model of Alzheimer disease.

2. The observations of this study suggest that SIRT3 deficiency-induced brain mitochondrial dysfunction and neuroinflammation in metabolic syndrome may play a role in late-life cognitive decline.

3. while NMN protected perfused hearts against ischemia-reperfusion (injury , this protection was insensitive to the SIRT1 inhibitor splitomicin. Although NMN-induced cardioprotection was absent in Sirt3(-/-) hearts (recovery 9+/-5%), this was likely due to enhanced baseline injury in Sirt3(-/-) , since similar injury levels in WT hearts also blunted protective efficacy of NMN

4. The SIRT3/SOD2 is required for regulating mitochondrial stress and plays a vital role in osteoblast differentiation and bone formation.

5. Sirt3 loss-of-function enhances experimental thrombosis in vivo via an increase of neutrophil extracellular traps and elevation of TF suggesting thrombo-protective effects of endogenous Sirt3.

6. SIRT3 activity promotes allogeneic donor T cell responses and reactive oxygen species production without altering T cell cytokine or cytolytic functions

7. The role of SIRT3 in the development of nonalcoholic fatty liver disease, impaired intestinal permeability and gut microbiota dysbiosis.

8. that SIRT3 dysfunction leads to p53-mediated mitochondrial and neuronal damage in Alzheimer's disease

9. Findings suggest that adipocyte SIRT3 is dispensable for maintaining normal adipose tissue mitochondrial function and whole body metabolism.

10. The level of Sirt3 in cerebral infarct region is decreased after ischemic stroke.

11. Sirt3 deficiency aggravates contrast-induced acute kidney injury.

12. Study provides evidence that neuronal networks in the hippocampus of mice adapt to intermittent food deprivation by up-regulating GABAergic inhibitory neurotransmission via a mechanism requiring SIRT3 and involving a reduction in mitochondrial oxidative stress.

13. SIRT3 knockout cells upregulated the diversion of glutamine into de novo nucleotide synthesis through hyperactive mTORC1 signaling.

14. Increased levels of miR-195 in failing myocardium regulate a novel pathway that involves direct SIRT3 suppression and enzymatic inhibition via increased acetylation of pyruvate dehydrogenase and ATP synthase that are essential for cardiac energy metabolism.

15. Study results demonstrated that Sirt3 was downregulated in cartilage chondrocytes from IL-1beta induced osteoarthritis mouse model and Sirt3 expression is associated with the progression of osteoarthritis, it is also involved in the clearance of dysfunctional mitochondria via mitophagy in chondrocytes.

16. long-term potentiation was impaired in the Sirt3-knockout mice

17. The data of this study suggested that Sirt3 KO mice show neuroprotection by a compensatory rise in Sirt1 rather than the loss of Sirt3 after stroke.

18. these results established the SIRT3-Foxo3a-catalase pathway as a critical factor in the maintenance of endothelial homeostasis and point to an important role of EndoMT in the vascular pathology of renal fibrosis, which may provide a new therapeutic target to impede the progression of hypertensive renal injury.

19. study demonstrated that SIRT3 deficiency exacerbated CCl 4 -induced impairment of the liver in mice, and the mechanism might be related to enhanced oxidative stress.

20. Studied antiobesity effect of myricetin in adipose tissue and found effect is mediated thru upregulation of sirtuin 3 (SIRT3).

Cow (Bovine) Sirtuin 3 (SIRT3) interaction partners

1. the novel 12-bp indel of SIRT1 gene, the 7-bp indel of SIRT2 gene and the 26-bp indel of SIRT3 gene were firstly reported, respectively. The association analysis indicated that the indels within SIRT1 and SIRT2 genes were significantly associated with body measurement traits such as body weight, chest circumference, height at hip cross, hip width, body height, etc.

2. The results indicate that the polymorphisms in transcription factor binding sites of SIRT3 promoter may affect the transcriptional activity of SIRT3, and thus alter intramuscular fat content in beef cattle.

3. The results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

4. The expression profile of sirtuin 1 and sirtuin 3 in the liver, muscle, and adipose tissue of calves and bulls is reported.