anti-Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2) Antibodies

SLC3A2 is a member of the solute carrier family and encodes a cell surface, transmembrane protein. Additionally we are shipping SLC3A2 Proteins (29) and SLC3A2 Kits (16) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SLC3A2 6520 P08195
SLC3A2 50567 Q794F9
SLC3A2 17254 P10852
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Top anti-SLC3A2 Antibodies at antibodies-online.com

Showing 10 out of 381 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB SLC3A2 Antibody (C-term) (ABIN654111) immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining ABIN2843993 staining SLC3A2 in human placenta tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody (1/25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody. Dilution: 1:25 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated IP, IHC (p), ELISA, WB Immunochemical staining of human SLC3A2 in human kidney with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). Immunochemical staining of human SLC3A2 in human placenta with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of p 100 μg Log in to see 14 to 16 Days
$218.90
Details
Human Rabbit Un-conjugated IHC (p), WB WB Image Sample (30 ug of whole cell lysate) A: Molt-4 , 7.5% SDS PAGE antibody diluted at 1:1000 IHC-P Image Immunohistochemical analysis of paraffin-embedded SCC15 xenograft, using CD98, antibody at 1:100 dilution. 100 μL Log in to see 3 to 4 Days
$466.18
Details
Human Mouse Un-conjugated FACS, IHC (p), IP Surface staining of human peripheral blood cells with anti-human CD98 (MEM-108) FITC. Cells in the monocyte gate were used for analysis. Surface staining of human peripheral blood monocytes with anti-human CD98 (MEM-108) purified, GAM-APC. 0.1 mg Log in to see 5 to 7 Days
$360.22
Details
Human Rabbit Un-conjugated IHC (p), IHC, WB Western Blot: CD98 Antibody [NBP1-32148] - Sample (30 ug of whole cell lysate) A: Molt-4 7.5% SDS PAGE; antibody diluted at 1:1000. Immunohistochemistry-Paraffin: CD98 Antibody [NBP1-32148] - Paraffin-embedded SCC15 xenograft, using antibody at 1:100 dilution. 0.1 mL Log in to see 7 to 9 Days
$516.98
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat colitis tissue labeled with Anti CD98 Polyclonal Antibody, Unconjugated (ABIN719546) at 1:200 followed by conjugation to the secondary antibody and DAB staining Lane 1: rat brain lysates Lane 2: human colon carcinoma lysates probed with Anti CD98 Polyclonal Antibody, Unconjugated (ABIN719546) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band 68kD. Observed band size: 68kD. 100 μL Log in to see 3 to 7 Days
$329.45
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 16 Days
$181.73
Details
Human Rabbit Un-conjugated WB Western blot analysis of CD98 expression in SW480 (A), SKOV3 (B), mouse kidney (C), mouse lung (D) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Mouse FITC FACS, IHC (p), IP Surface staining of human peripheral blood cells with anti-human CD98 (MEM-108) FITC. Cells in the monocyte gate were used for analysis. 100 Tests Log in to see 5 to 7 Days
$428.84
Details
Human Mouse Biotin FACS, IHC (p), IP Surface staining of human peripheral blood cells with anti-human CD98 (MEM-108) FITC. Cells in the monocyte gate were used for analysis. 0.1 mg Log in to see 5 to 7 Days
$428.84
Details

Top referenced anti-SLC3A2 Antibodies

  1. Rat (Rattus) Polyclonal SLC3A2 Primary Antibody for IHC (fro), WB - ABIN548991 : Segawa, Fukasawa, Miyamoto, Takeda, Endou, Kanai: Identification and functional characterization of a Na+-independent neutral amino acid transporter with broad substrate selectivity. in The Journal of biological chemistry 1999 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal SLC3A2 Primary Antibody for IHC (fro), WB - ABIN548987 : Kim, Kanai, Chairoungdua, Cha, Matsuo, Kim, Inatomi, Sawa, Ida, Endou: Human cystine/glutamate transporter: cDNA cloning and upregulation by oxidative stress in glioma cells. in Biochimica et biophysica acta 2001 (PubMed)
    Show all 5 Pubmed References

  3. Human Monoclonal SLC3A2 Primary Antibody for FACS, IP - ABIN533485 : Nakamura, Sato, Yang, Miyagawa, Harasaki, Tomita, Matsuoka, Noma, Iwai, Minato: 4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer. in The Journal of biological chemistry 1999 (PubMed)
    Show all 5 Pubmed References

  4. Human Monoclonal SLC3A2 Primary Antibody for FACS - ABIN536606 : Dalton, Christian, Redman, Sargent, Boyd: Differential effect of cross-linking the CD98 heavy chain on fusion and amino acid transport in the human placental trophoblast (BeWo) cell line. in Biochimica et biophysica acta 2007 (PubMed)
    Show all 3 Pubmed References

  5. Human Monoclonal SLC3A2 Primary Antibody for FACS - ABIN536605 : Cho, Skubitz, Katz, Chain: CD98-dependent homotypic aggregation is associated with translocation of protein kinase Cdelta and activation of mitogen-activated protein kinases. in Experimental cell research 2003 (PubMed)
    Show all 3 Pubmed References

  6. Human Monoclonal SLC3A2 Primary Antibody for Func, FACS - ABIN610336 : Fisher, Pevsner, Burgoyne: Control of fusion pore dynamics during exocytosis by Munc18. in Science (New York, N.Y.) 2001 (PubMed)
    Show all 2 Pubmed References

  7. Human Monoclonal SLC3A2 Primary Antibody for Func, FACS - ABIN610337 : Shuang, Zhang, Fletcher, Groblewski, Pevsner, Stuenkel: Regulation of Munc-18/syntaxin 1A interaction by cyclin-dependent kinase 5 in nerve endings. in The Journal of biological chemistry 1998 (PubMed)
    Show all 2 Pubmed References

  8. Human Polyclonal SLC3A2 Primary Antibody for IF (p), IHC (p) - ABIN719546 : Hutterer, Ebner, Riemenschneider, Willuweit, McCoy, Egger, Schröder, Wendl, Hellwig, Grosse, Menhart, Proescholdt, Fritsch, Urbach, Stockhammer, Roelcke, Galldiks, Meyer, Langen, Hau, Trinka: Epileptic Activity Increases Cerebral Amino Acid Transport Assessed by 18F-Fluoroethyl-l-Tyrosine Amino Acid PET: A Potential Brain Tumor Mimic. in Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2016 (PubMed)
    Show all 2 Pubmed References

  9. Mouse (Murine) Monoclonal SLC3A2 Primary Antibody for FACS - ABIN2472891 : Kang, Zhao, Lovaas, Eisenberg, Greene: Clathrin-independent internalization of normal cellular prion protein in neuroblastoma cells is associated with the Arf6 pathway. in Journal of cell science 2009 (PubMed)

More Antibodies against SLC3A2 Interaction Partners

Human Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2) interaction partners

  1. Data suggest that SLC3A2-NRG1 should be considered a therapeutic target for patients with invasive mucinous adenocarcinoma of the lung (IMA).

  2. These results demonstrate a novel fundamental role of LAT1 to support the protein expression of 4F2hc via a chaperone-like function in chorionic trophoblasts.

  3. SLC3A2 is upregulated in osteosarcoma and plays a crucial role in tumor growth.

  4. Expression levels of CD98 and beta1-integrin-A (the activated form of beta1-integrin) were significantly increased in hepatocellular carcinoma (HCC) tissues relative to those of normal liver tissues.

  5. Data suggest that increased CD98 (4F2hc) expression plays an essential role in tumor aggressiveness and metastasis.

  6. Study demonstrated that the mRNA expression levels of the two system xc- subunits, SLC7A11 and SLC3A2, in peripheral white blood cells are lowered in patients with schizophrenia than healthy individuals

  7. ubiquitylation and the resulting downregulation of CD98 can limit cell proliferation and clonal expansion.

  8. exposure to diesel exhaust particle extract induces functional overexpression of the amino acid transporter LAT1/CD98hc in lung cells

  9. The detergent-induced stabilization of the purified human 4F2hc-LAT2 complex presented here paves the way towards its crystallization and structure determination at high-resolution

  10. HSV-1 recruited cellular fusion regulatory proteins CD98hc and beta1 integrin to the nuclear membrane for viral de-envelopment fusion.

  11. CD98-mediated phosphorylation of focal adhesion kinase may facilitate the assembly of pro-tumorigenic signaling complexes and the subsequent amplification of a positive feedback loop of CD98/integrins/FAK/RhoA/ROCK.

  12. data suggest that genetic variation of rs1059292 in CD98 gene may affect clinical outcome of NSCLC in Chinese population

  13. Overexpression of CD98, integrin beta1, integrin beta3 and Fak is associated with the progression and liver metastases of colorectal cancer

  14. Studied and identified the eukaryotic protein CD98hc as a partner for Brucella T4SS subunit VirB2.

  15. CAP-D3 down-regulates transcription of genes that encode amino acid transporters (SLC7A5 and SLC3A2) to promote bacterial autophagy by colon epithelial cells.

  16. High CD98hc expression is associated with non-small cell lung cancer.

  17. observed a correlation between less differentiated and more aggressive clear cell renal cell cancer and CD98hc expression; found that CD98hc is not only a descriptive marker for aggressive cancers, but bears a major regulatory role of malignant cell function

  18. We detected elevated levels of antipeptide responses, but failed to detect reactivity against native CD98-expressing HeLa cells in sera of immunized mice.

  19. The extracellular domain of 4F2hc interacts with LAT2, almost completely covering its extracellular face and stabilizing the solubilized transporter.

  20. heteromerization of y+LAT1 and 4F2hc within the cell is not disrupted by any of the tested LPI mutations

Mouse (Murine) Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2) interaction partners

  1. Cell metabolism regulates integrin mechanosensing via an SLC3A2-dependent sphingolipid biosynthesis pathway.

  2. Slc3a2 is required for branched-chain amino-acid-dependent maintenance of Treg cells.

  3. CD98hc expression in vascular smooth muscle cells contributes to the formation of plaques that are morphologically more stable, and thereby protects against atherothrombosis.

  4. These results demonstrate a novel fundamental role of LAT1 to support the protein expression of 4F2hc via a chaperone-like function in chorionic trophoblasts.

  5. CD98 is required for endothelial cell growth. CD98-specific reagents could have a dual anticancer effect: directly by inhibiting tumor cell proliferation and indirectly by preventing tumor angiogenesis

  6. Taken together, our data indicate that T cell-specific deletion of CD98hc can contribute to the prevention of GvHD development due to the attenuation of lymphocyte migration and by increasing the generation of Treg cells.

  7. data establish CD98hc as a master protective gene at the cross-road of redox control and AA availability, making it a relevant therapeutic target in cancer.

  8. ubiquitylation and the resulting downregulation of CD98 can limit cell proliferation and clonal expansion.

  9. CD98hc mediated this stiffness sensing by increasing Rho kinase (ROCK) activity.

  10. Mice lacking CD98hc in B cells are protected from experimental autoimmune encephalomyelitis.

  11. CD98 heavy chain is crucial for T cell-mediated autoimmune colitis. CD98 heavy chain deficiency in T cells is involved in increasing induced regulatory T cells.

  12. The role of SLC3A2 in keratinocytes is not in cell adhesion but, instead, in cell proliferation and migration through modulating integrin signaling by the Src-RhoA pathway.

  13. CD98-dependent amino acid transport increased renal tubular epithelial cell proliferation is mediated by Erk and p38 MAPK signaling.

  14. Investigated the contribution of CD98 to intestinal tumorigenesis in Apc(Min/+) mice and the underlying mechanism of action.

  15. when the CD98hc deficient macrophages were stimulated with either IFN-gamma/LPS or IL-4, the production of NO(2) or arginase-I decreased in comparison to that observed in the control macrophages

  16. T cell-specific deficiency in CD98hc can contribute to cardiac allograft permanent acceptance correlating with the attenuation of lymphocyte migration and by increasing the generation of regulatory T cells.

  17. Taken together, these observations show that the combination of an inflammatory context and intestinal epithelial cell expression of CD98 affects the regulation of miRNA expression in colonic epithelial and immune cells.

  18. CD98 expression modulates intestinal homeostasis, inflammation, and colitis-associated cancer in mice

  19. Exogenous putrescine is transported into gastrointestinal tract by caveolin-1- and NOS2-dependent mechanisms. Solute carrier transporter SLC3A2 can function bidirectionally to import putrescine under conditions of low tissue polyamines.

  20. CD98 molecules are essential for mouse embryogenesis

Zebrafish Solute Carrier Family 3 (Activators of Dibasic and Neutral Amino Acid Transport), Member 2 (SLC3A2) interaction partners

  1. Slc3a2 inhibits the RhoA/ROCK pathway via phosphorylation of c-Src to modulate YSL microtubule dynamics.

SLC3A2 Antigen Profile

Protein Summary

This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with SLC3A2

  • solute carrier family 3 member 2 (SLC3A2) antibody
  • solute carrier family 3 member 2 (Slc3a2) antibody
  • solute carrier family 3 (amino acid transporter heavy chain), member 2 L homeolog (slc3a2.L) antibody
  • solute carrier family 3 (amino acid transporter heavy chain), member 2 S homeolog (slc3a2.S) antibody
  • solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 (Slc3a2) antibody
  • solute carrier family 3 (amino acid transporter heavy chain), member 2a (slc3a2a) antibody
  • 4F2 antibody
  • 4F2HC antibody
  • 4T2HC antibody
  • AI314110 antibody
  • Cd98 antibody
  • CD98HC antibody
  • fc65h12 antibody
  • Ly-10 antibody
  • Ly-m10 antibody
  • Ly10 antibody
  • Mdu1 antibody
  • MGC53951 antibody
  • MGC53965 antibody
  • Mgp-2hc antibody
  • NACAE antibody
  • SLC3A2 antibody
  • wu:fc65h12 antibody

Protein level used designations for SLC3A2

4F2 cell-surface antigen heavy chain , CD98 heavy chain , antigen defined by monoclonal antibody 4F2, heavy chain , antigen identified by monoclonal antibodies 4F2, TRA1.10, TROP4, and T43 , lymphocyte activation antigen 4F2 large subunit , monoclonal antibody 44D7 , solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 , 4F2hc , antigen identified by monoclonal antibodies 4F2 , solute carrier family 3, member 2 , blood-brain barrier large neutral amino acid transporter heavy chain 4F2 , CD98 antigen , type II transmembrane protein , solute carrier family 3 (amino acid transporter heavy chain), member 2a , solute carrier family 3, member 2a

GENE ID SPECIES
6520 Homo sapiens
50567 Rattus norvegicus
379133 Xenopus laevis
379938 Xenopus laevis
451271 Pan troglodytes
483777 Canis lupus familiaris
507107 Bos taurus
100009363 Oryctolagus cuniculus
100064046 Equus caballus
100144589 Sus scrofa
100172374 Pongo abelii
100585864 Nomascus leucogenys
17254 Mus musculus
796322 Danio rerio
101866986 Macaca fascicularis
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