anti-Solute Carrier Family 7 (Amino Acid Transporter, L-Type), Member 8 (SLC7A8) Antibodies

Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Additionally we are shipping SLC7A8 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SLC7A8 23428 Q9UHI5
SLC7A8 84551 Q9WVR6
SLC7A8 50934 Q9QXW9
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Top anti-SLC7A8 Antibodies at antibodies-online.com

Showing 10 out of 37 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: SLC7A8 Sample Tissue: Human 293T Whole Cell Antibody Dilution: 1ug/ml 100 μL 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated IHC, IHC (p), WB 100 μL 11 to 14 Days
$522.50
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-SLC7A8 Antibody Titration: 1.25ug/ml Positive Control: HepG2 cell lysate Host: Rabbit Target Name: SLC7A8 Sample Type: Fetal Liver Cell lysates Antibody Dilution: 1.0ug/ml 100 μL 2 to 3 Days
$249.00
Details
Human Mouse Un-conjugated FACS, IF, IHC, IHC (p), IP, WB 100 μL 11 to 14 Days
$522.50
Details
Human Mouse Un-conjugated FACS, IF, IP, IHC, WB HEK293T cells transfected with either pCMV6-ENTRY SLC7A8 (RC208586) (Red) or empty vector control plasmid (Blue) were immunostained with anti-SLC7A8 mouse monoclonal (ABIN2452328, Dilution 1:1,000), and then analyzed by flow cytometry. HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SLC7A8 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-SLC7A8. 0.1 mL 2 to 3 Days
$462.00
Details
Human Mouse Un-conjugated FACS, IHC, WB Immunohistochemical staining of paraffin-embedded Carcinoma of kidney tissue using anti-SLC7A8mouse monoclonal antibody. (ABIN2452597, Dilution 1:50) 0.1 mL 2 to 3 Days
$462.00
Details
Human Mouse Un-conjugated FACS, IF, IHC, IHC (p), IP Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL 11 to 14 Days
$484.00
Details
Human Mouse Un-conjugated FACS, IF, IHC, IHC (p), WB Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) 100 μL 11 to 14 Days
$639.83
Details
Human Mouse Un-conjugated FACS, IHC, IHC (p), WB Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) 100 μL 11 to 14 Days
$639.83
Details
Cow Rabbit Un-conjugated IHC, IHC (p), WB Anti-SLC7A8 / LAT2 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. This image was taken for the unconjugated form ... 100 μL 11 to 14 Days
$639.83
Details

Top referenced anti-SLC7A8 Antibodies

  1. Human Monoclonal SLC7A8 Primary Antibody for FACS, IF - ABIN2732181 : Cicone, Minniti, Oliva, Carideo, Prior, Scopinaro, Giangaspero, Arcella: Expression of large neutral amino acid transporters LAT1 and LAT2 in medulloblastoma. in Brain tumor pathology 2018 (PubMed)

  2. Human Monoclonal SLC7A8 Primary Antibody for FACS, IHC - ABIN2732183 : Balthasar, Stangl, Widhalm, Granitzer, Hengstschläger, Gundacker: Methylmercury Uptake into BeWo Cells Depends on LAT2-4F2hc, a System L Amino Acid Transporter. in International journal of molecular sciences 2018 (PubMed)

More Antibodies against SLC7A8 Interaction Partners

Human Solute Carrier Family 7 (Amino Acid Transporter, L-Type), Member 8 (SLC7A8) interaction partners

  1. Data reveal that LAT2 functions as an oncogenic protein and could regulate glutamine-dependent mTOR activation to promote glycolysis and decrease GEM sensitivity in pancreatic cancer

  2. The detergent-induced stabilization of the purified human 4F2hc-LAT2 complex presented here paves the way towards its crystallization and structure determination at high-resolution

  3. LAT2 genes may play important roles in leiomyoma cell proliferation and regulate leiomyoma growth

  4. LAT1 and LAT2 were overexpressed in both pheochromocytoma and medullary thyroid carcinoma by comparison with normal tissues.

  5. LAT1 and LAT2 are present and functional in the syncytiotrophoblast MVM, whereas LAT2 is also expressed in the BM and in the fetal capillary endothelium.

  6. Compared with the adult cerebral cortex, mRNAs encoding OATP1A2, OATP1C1, OATP3A1 variant 2, OATP4A1, LAT2 and CD98 were reduced in fetal cortex at different gestational ages, whilst mRNAs encoding MCT8, MCT10, OATP3A1 variant 1 and LAT1 were similar.

  7. the interaction of CD98/LAT2 with ICAM-1, found to be expressed to the basolateral domain, and the potential of such interaction on intracellular signal activation in Caco2-BBE cell monolayers

  8. identify LAT1 and LAT2 as members of system L that mediate transmembrane movement of l-CSNO

  9. Genetic variation in LAT1 and LAT2 does not appear to be a major cause of inter-individual variability in pharmacokinetics and of adverse reactions to melphalan.

Mouse (Murine) Solute Carrier Family 7 (Amino Acid Transporter, L-Type), Member 8 (SLC7A8) interaction partners

  1. distinct molecular LAT2-features determine bidirectional amino acid transport but only an unidirectional thyroid hormone import.

  2. Circulating thyroid hormones, thyrotropin and thyroid hormone-responsive genes remained unchanged in Slc7a8(-/-) mice, possibly because of functional compensation by the thyroid hormone transporter Mct8, which is co-expressed in many cell types

  3. In a neuronal cell model, y+,L and y+ transport systems are the predominant form of arginine uptake mechanisms and the transport of arginine is altered by membrane potential and redox factors.

  4. the aromatic amino acid diffusion pathway TAT1 can control neutral amino acid efflux via neighboring exchanger LAT2-4F2hc, by recycling its aromatic influx substrates

  5. System L functions as influx and/or efflux transport machinery displaying a greater propensity for the outward transport of large and small neutral amino acids.

  6. The positive effect of non-T cell activation linker (NTAL) on Akt phosphorylation and mast cell survival requires LAT.

  7. LAT1, and LAT2 mRNAs were detected in fetal and postnatal femurs and in MC3T3-E1 cells, while OATP1 and NTCP mRNAs were not.

SLC7A8 Antigen Profile

Protein Summary

Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney (By similarity).

Gene names and symbols associated with SLC7A8

  • solute carrier family 7 member 8 (SLC7A8) antibody
  • solute carrier family 7 member 8 (Slc7a8) antibody
  • solute carrier family 7 member 8 L homeolog (slc7a8.L) antibody
  • solute carrier family 7 member 8 (slc7a8) antibody
  • solute carrier family 7 (amino acid transporter, L-type), member 8 (SLC7A8) antibody
  • solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 (Slc7a8) antibody
  • solute carrier family 7 (amino acid transporter light chain, L system), member 8b (slc7a8b) antibody
  • 4F2LC-5 antibody
  • AA408822 antibody
  • lat2 antibody
  • Lat4 antibody
  • lpi-pc1 antibody
  • si:ch211-14a17.3 antibody
  • si:zc14a17.3 antibody
  • slc7a8 antibody
  • XAA2 antibody

Protein level used designations for SLC7A8

L-type amino acid transporter 2 , integral membrane protein E16H , large neutral amino acids transporter small subunit 2 , solute carrier family 7 (amino acid transporter, L-type), member 8 , solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 , cationic amino acid transporter y+ system , solute carrier family 7 member 8 , glycoprotein-associated amino acid transporter LAT2 , 4F2-LC5 , mLAT2 , solute carrier family 8 (cationic amino acid transporter, y+ system), member 7 , solute carrier family 7 (amino acid transporter light chain, L system), member 8 , zmp:0000000645 , zmp:0000000781

GENE ID SPECIES
23428 Homo sapiens
84551 Rattus norvegicus
380297 Xenopus laevis
394580 Xenopus (Silurana) tropicalis
452793 Pan troglodytes
490608 Canis lupus familiaris
536818 Bos taurus
713511 Macaca mulatta
100009408 Oryctolagus cuniculus
100134829 Sus scrofa
100172820 Pongo abelii
50934 Mus musculus
100007990 Danio rerio
100052453 Equus caballus
100717482 Cavia porcellus
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