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TSLP encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. Additionally we are shipping Thymic Stromal Lymphopoietin Antibodies (195) and Thymic Stromal Lymphopoietin Kits (86) and many more products for this protein.
Showing 10 out of 42 products:
TSLP-induced phosphorylation of l-plastin (show LCP1 Proteins) is increased in atopic dermatitis and increases eosinophil migration.
a hit expansion exercise yielded additional active compounds that could be amenable to further optimization, providing an opportunity to dissociate TSLP inhibition from other non-desired activities. This study illustrates the potential of phenotypic drug discovery to complement target based approaches by providing new chemistry and biology leads
study found that among patients with atopic dermatitis (AD), common FLG (show FGFR1 Proteins) null mutations are associated with earlier AD onset in a dose-dependent manner, whereas TSLP rs1898671 appears unrelated to the timing of AD onset
lactobacilli from the omnivorous group and all bifidobacteria significantly down-regulated IL-8 (show IL8 Proteins). Notably, both genera also lowered the TSLP expression in stimulated Caco-2 cells, regardless of the diet regimen.
this review focuses on recent advances on the effects of TSLP on obstetrical and gynecological diseases, including pregnancy failure, endometriosis, and cervical cancer
The increase in TSLP and TNF-alpha (show TNF Proteins) level observed in IS fluid was found to correlate with disease severity. The increased TSLP production from asthma sputum cells was abrogated by the addition of rIL (show PDLIM4 Proteins)-37. Regulation of TSLP pathway may be a therapeutic approach for asthma.
House dust mite sublingual immunotherapy downregulated Th2-type immune responses mediated by the TSLP-OX40L (show TNFSF4 Proteins) signaling pathway in patients with persistent moderate to severe allergic rhinitis.
The results suggest that IL-1beta (show IL1B Proteins) may be an early key mediator for the acquisition of an Atopic dermatitis (AD) phenotype through induction of thymic stromal lymphopoietin (TSLP) and alteration of the epidermal homeostasis.
House dust mite exposure increases the expression of TSLP through PI3K/Akt signalin (show CDH1 Proteins)g pathway in human bronc (show HDAC3 Proteins)hial epithelial 16HBE cells.
Posttranslational modifications control the functional activity of TSLP in humans and overproduction of TSLP may be a key trigger for the amplification of type 2 inflammation in diseases
blockading the JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) pathway restrains inflammatory Th2 cell response induced by TSLP-DCs in allergic rhinitis.
study concludes that IL-33 (show IL33 Proteins) and TSLP are required for epithelial cell IL-25 (show IL25 Proteins) expression, mucous metaplasia, and ILC2 expansion following early-life rhinovirus infection
TSLP plays a role in dysfunction of airway epithelial adherens junctions E-cadherin (show CDH1 Proteins) in house dust mite (HDM (show HDAC3 Proteins))-induced asthma. Mice treated with an anti-TSLP mAb ameliorated airway inflammation, the decreasing and aberrant distribution of E-cadherin (show CDH1 Proteins) and beta-catenin (show CTNNB1 Proteins) as well as phosphorylation(p)-AKT (show AKT1 Proteins) induced by HDM (show HDAC3 Proteins). In vitro, HDM (show HDAC3 Proteins) increased the expression of TSLP and E-cadherin (show CDH1 Proteins) dysfunction by PI3K/Akt (show AKT1 Proteins) signaling pathway.
this study shows that TSLP is a key target of Mi-2beta (show CHD4 Proteins) in keratinocytes, and that loss of TSLP signaling in regulatory T cells prevents their activation
These data demonstrate that multiple pathogenic strains of RSV induce IL-13 (show IL13 Proteins)-producing group 2 innate lymphoid cell proliferation and activation through a TSLP-dependent mechanism in a murine model and suggest the potential therapeutic targeting of TSLP during severe RSV infection.
the effects of TSLP on myeloid cells are crucial in reducing the multiple organ failure that is associated with systemic inflammation.
The inflammatory phenotype in barrier-defective skin is shaped by counterregulation between the TSLP/type 2 and IL-23 (show IL23A Proteins)/type 17 axes.
this study shows that activation of primed TH2 cells occurs independently of group 2 innate lymphoid cells or their cytokines but that the effector function of both cell types was dependent on combinatorial exposure to IL-33 (show IL33 Proteins), IL-25 (show IL25 Proteins) and TSLP
TNF-alpha (show TNF Proteins) and IL-1beta (show IL1B Proteins), which are partly produced by LPS (show TLR4 Proteins)-activated leukocytes, contribute to TSLP production via TLR4 (show TLR4 Proteins) activation in vivo.
IL-33 (show IL33 Proteins)-ERK (show EPHB2 Proteins)/JNK (show MAPK8 Proteins)/p38 (show CRK Proteins)/Egr-1 (show EGR1 Proteins)/TSLP axis involved in allergic skin Th2 inflammation
This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The protein promotes T helper type 2 (TH2) cell responses that are associated with immunity in various inflammatory diseases, including asthma, allergic inflammation and chronic obstructive pulmonary disease. The protein is therefore considered a potential therapeutic target for the treatment of such diseases. Alternative splicing of this gene results in multiple transcript variants.
thymic stromal lymphopoietin
, thymic stromal lymphopoetin
, thymic stroma-derived lymphopoietin